5CNTA

Crystal structure of the datp inhibited e. coli class ia ribonucleotide reductase complex bound to udp and datp at 3.25 angstroms resolution
Total Genus 280
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
280
sequence length
734
structure length
734
Chain Sequence
NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli (strain k12)
molecule keywords Ribonucleoside-diphosphate reductase 1 subunit alpha
total genus 280
structure length 734
sequence length 734
chains with identical sequence B, C, D
ec nomenclature ec 1.17.4.1: Ribonucleoside-diphosphate reductase.
pdb deposition date 2015-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00317 Ribonuc_red_lgN Ribonucleotide reductase, all-alpha domain
A PF02867 Ribonuc_red_lgC Ribonucleotide reductase, barrel domain
A PF03477 ATP-cone ATP cone domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.20.70.20 Alpha Beta Alpha-Beta Barrel Anaerobic Ribonucleotide-triphosphate Reductase Large Chain Anaerobic Ribonucleotide-triphosphate Reductase Large Chain 5cntA02
3TB9A 3O0OA 2CVVA 3RSRA 1MZOA 1H17A 2XO4A 2WGHA 1CM5A 3S8CA 1XJMA 1XJJA 1XJKA 2XAKA 1H18A 2ZLFA 2XAVA 2XAZA 6R1RA 2CVWA 5CNVA 4X3VA 1H7BA 4R1RA 1PEQA 1XJFA 2BQ1E 2CVSA 2CVXA 1R8WA 2XAPA 2R1RA 2PFLA 1ZYZA 3O0NA 3S8AA 1ZZDA 2CVTA 3TBAA 3K8TA 3PFLA 1XJEA 2EUDA 1PEMA 1XJNA 1L1LA 2F3OA 1H79A 1RLRA 4ERMA 1R1RA 1XJGA 2XO5A 1H16A 1HK8A 3S87A 3S8BA 2CVYA 2ZLGA 3R1RA 1H78A 7R1RA 5CNUA 1H7AA 1R9DA 2XAWA 3HNFA 2X0XA 3HNEA 2XAYA 2HA9A 5CNSA 1PEUA 2Y8NA 5R1RA 1PEOA 5CNTA 2CVUA 3HNCA 1QHMA 2YAJA 4MTJA 3HNDA 2XAXA 3O0QA
chains in the Genus database with same CATH superfamily
5FAVA 5KDPA 3TB9A 3O0OA 2CVVA 3RSRA 1MZOA 1H17A 2XO4A 2WGHA 1CM5A 3S8CA 1XJMA 1XJJA 1XJKA 2XAKA 1H18A 2ZLFA 2XAVA 2XAZA 6R1RA 2CVWA 5CNVA 4X3VA 5A0ZA 1H7BA 4R1RA 1PEQA 1XJFA 2BQ1E 2CVSA 2CVXA 1R8WA 2XAPA 2R1RA 2PFLA 1ZYZA 3O0NA 3S8AA 1ZZDA 2CVTA 3TBAA 5A0UA 3K8TA 3PFLA 1XJEA 2EUDA 5FAWA 1PEMA 1XJNA 1L1LA 2F3OA 1H79A 1RLRA 4ERMA 1R1RA 1XJGA 2XO5A 5FAUA 5FAYA 1H16A 1HK8A 3S87A 3S8BA 2CVYA 2ZLGA 3R1RA 1H78A 7R1RA 5CNUA 1H7AA 1R9DA 2XAWA 3HNFA 2X0XA 3HNEA 2XAYA 2HA9A 5CNSA 1PEUA 2Y8NA 5R1RA 1PEOA 5CNTA 2CVUA 3HNCA 1QHMA 2YAJA 4MTJA 3HNDA 2XAXA 3O0QA
chains in the Genus database with same CATH topology
5FAVA 5KDPA 3TB9A 3O0OA 2CVVA 3RSRA 1MZOA 1H17A 2XO4A 2WGHA 1CM5A 3S8CA 1XJMA 1XJJA 1XJKA 2XAKA 1H18A 2ZLFA 2XAVA 2XAZA 6R1RA 2CVWA 5CNVA 4X3VA 5A0ZA 1H7BA 4R1RA 1PEQA 1XJFA 2BQ1E 2CVSA 2CVXA 1R8WA 2XAPA 2R1RA 2PFLA 1ZYZA 3O0NA 3S8AA 1ZZDA 2CVTA 3TBAA 5A0UA 3K8TA 3PFLA 1XJEA 2EUDA 5FAWA 1PEMA 1XJNA 1L1LA 2F3OA 1H79A 1RLRA 4ERMA 1R1RA 1XJGA 2XO5A 5FAUA 5FAYA 1H16A 1HK8A 3S87A 3S8BA 2CVYA 2ZLGA 3R1RA 1H78A 7R1RA 5CNUA 1H7AA 1R9DA 2XAWA 3HNFA 2X0XA 3HNEA 2XAYA 2HA9A 5CNSA 1PEUA 2Y8NA 5R1RA 1PEOA 5CNTA 2CVUA 3HNCA 1QHMA 2YAJA 4MTJA 3HNDA 2XAXA 3O0QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TB9 A;  3O0O A;  2CVV A;  3RSR A;  1MZO A;  1H17 A;  2XO4 A;  2WGH A;  1CM5 A;  3S8C A;  1XJM A;  1XJJ A;  1XJK A;  2XAK A;  1H18 A;  2ZLF A;  2XAV A;  2XAZ A;  6R1R A;  2CVW A;  5CNV A;  4X3V A;  1H7B A;  4R1R A;  1PEQ A;  1XJF A;  2BQ1 E;  2CVS A;  2CVX A;  1R8W A;  2XAP A;  2R1R A;  2PFL A;  1ZYZ A;  3O0N A;  3S8A A;  1ZZD A;  2CVT A;  3TBA A;  3K8T A;  3PFL A;  1XJE A;  2EUD A;  1PEM A;  1XJN A;  1L1L A;  2F3O A;  1H79 A;  1RLR A;  4ERM A;  1R1R A;  1XJG A;  2XO5 A;  1H16 A;  1HK8 A;  3S87 A;  3S8B A;  2CVY A;  2ZLG A;  3R1R A;  1H78 A;  7R1R A;  5CNU A;  1H7A A;  1R9D A;  2XAW A;  3HNF A;  2X0X A;  3HNE A;  2XAY A;  2HA9 A;  5CNS A;  1PEU A;  2Y8N A;  5R1R A;  1PEO A;  5CNT A;  2CVU A;  3HNC A;  1QHM A;  2YAJ A;  4MTJ A;  3HND A;  2XAX A;  3O0Q A; 
#chains in the Genus database with same CATH topology
 5FAV A;  5KDP A;  3TB9 A;  3O0O A;  2CVV A;  3RSR A;  1MZO A;  1H17 A;  2XO4 A;  2WGH A;  1CM5 A;  3S8C A;  1XJM A;  1XJJ A;  1XJK A;  2XAK A;  1H18 A;  2ZLF A;  2XAV A;  2XAZ A;  6R1R A;  2CVW A;  5CNV A;  4X3V A;  5A0Z A;  1H7B A;  4R1R A;  1PEQ A;  1XJF A;  2BQ1 E;  2CVS A;  2CVX A;  1R8W A;  2XAP A;  2R1R A;  2PFL A;  1ZYZ A;  3O0N A;  3S8A A;  1ZZD A;  2CVT A;  3TBA A;  5A0U A;  3K8T A;  3PFL A;  1XJE A;  2EUD A;  5FAW A;  1PEM A;  1XJN A;  1L1L A;  2F3O A;  1H79 A;  1RLR A;  4ERM A;  1R1R A;  1XJG A;  2XO5 A;  5FAU A;  5FAY A;  1H16 A;  1HK8 A;  3S87 A;  3S8B A;  2CVY A;  2ZLG A;  3R1R A;  1H78 A;  7R1R A;  5CNU A;  1H7A A;  1R9D A;  2XAW A;  3HNF A;  2X0X A;  3HNE A;  2XAY A;  2HA9 A;  5CNS A;  1PEU A;  2Y8N A;  5R1R A;  1PEO A;  5CNT A;  2CVU A;  3HNC A;  1QHM A;  2YAJ A;  4MTJ A;  3HND A;  2XAX A;  3O0Q A; 
#chains in the Genus database with same CATH homology
 5FAV A;  5KDP A;  3TB9 A;  3O0O A;  2CVV A;  3RSR A;  1MZO A;  1H17 A;  2XO4 A;  2WGH A;  1CM5 A;  3S8C A;  1XJM A;  1XJJ A;  1XJK A;  2XAK A;  1H18 A;  2ZLF A;  2XAV A;  2XAZ A;  6R1R A;  2CVW A;  5CNV A;  4X3V A;  5A0Z A;  1H7B A;  4R1R A;  1PEQ A;  1XJF A;  2BQ1 E;  2CVS A;  2CVX A;  1R8W A;  2XAP A;  2R1R A;  2PFL A;  1ZYZ A;  3O0N A;  3S8A A;  1ZZD A;  2CVT A;  3TBA A;  5A0U A;  3K8T A;  3PFL A;  1XJE A;  2EUD A;  5FAW A;  1PEM A;  1XJN A;  1L1L A;  2F3O A;  1H79 A;  1RLR A;  4ERM A;  1R1R A;  1XJG A;  2XO5 A;  5FAU A;  5FAY A;  1H16 A;  1HK8 A;  3S87 A;  3S8B A;  2CVY A;  2ZLG A;  3R1R A;  1H78 A;  7R1R A;  5CNU A;  1H7A A;  1R9D A;  2XAW A;  3HNF A;  2X0X A;  3HNE A;  2XAY A;  2HA9 A;  5CNS A;  1PEU A;  2Y8N A;  5R1R A;  1PEO A;  5CNT A;  2CVU A;  3HNC A;  1QHM A;  2YAJ A;  4MTJ A;  3HND A;  2XAX A;  3O0Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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