5FAWA

T502a mutant of choline tma-lyase
Total Genus 345
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
345
sequence length
803
structure length
803
Chain Sequence
GLVPRGSHMGIPDGPTPRHVKLKENFLKQVPSITVQRAVAITKIAKENPGLPKPLLRAKTFRYCCETAPLVIQDHELIVGSPNGAPRAGAFSPEVAWRWLQDELDTIGSRPQDPFYISEEDKKVLREEVFPFWQNKSVDEFCEGQYREADLWEMSGESFVSDCSYHAVNGGGDSNPGYDVILMKKGMLDIQREAREKLEQLDYANPEDIDKIYFYKSVIETAEGVMIYARRLSAYAAELAARETDPRRKAELQKISEVNARVPAHAPSNFWEAIQAVWTVESLLVVEENQTGMSIGRVDQYMYPFYRADIDSGRLTEYEAFDLAGCMLVKMSEMMWITSEGASKFFAGYQPFVNMCVGGVTREGHDATNDLTYMLMDAVRHVRIYQPTLATRVHNKSPQKYLKKIVDVIRSGMGFPAVHFDDAHIKMMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWASTGYTQWPICIELVLNHGVPLWYGKKVTPDMGDLSQYDTYEKFEAAVKEQIRWITKNTSVATVISQRAHRELAPKPLMSLMYEGCMESGRDVSAGGAMYNFGPGVVWSGLATYVDSMAAIKKLVYDDRKYTLAQLNEALKADFAGYDQILADCLAAPKYGNDDDYADMIAADLVHFTETEHRKYKTLYSVLSHGTLSISNNTPFGQLLGASANGRRAWMPLSDGISPTQGADYKGPTAIIKSVSKMANDNMNIGMVHNFKLMSGLLDTPEGENGLITLIRTACMLGNGEMQFNYLDNELLLDAQKHPEKYRDLVVRVAGYSAFFVELCKDVQDEIISRTMLHGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
pubmed doi rcsb
molecule tags Lyase
source organism Desulfovibrio alaskensis
molecule keywords Choline trimethylamine-lyase
total genus 345
structure length 803
sequence length 803
chains with identical sequence B
ec nomenclature ec 4.3.99.4: Choline trimethylamine-lyase.
pdb deposition date 2015-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01228 Gly_radical Glycine radical
A PF02901 PFL-like Pyruvate formate lyase-like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.20.70.40 Alpha Beta Alpha-Beta Barrel Anaerobic Ribonucleotide-triphosphate Reductase Large Chain Anaerobic Ribonucleotide-triphosphate Reductase Large Chain 5fawA00
5FAWA 5FAVA 5FAUA 5A0ZA 5FAYA 5A0UA 5KDPA
chains in the Genus database with same CATH superfamily
3HNFA 2BQ1E 2CVYA 2XAXA 5A0ZA 4ERMA 5CNSA 2XO4A 2YAJA 1XJEA 2ZLFA 1XJMA 5CNTA 3O0OA 3HNDA 2XAKA 1RLRA 5FAYA 2ZLGA 2Y8NA 3RSRA 5CNUA 6R1RA 1HK8A 1MZOA 1QHMA 4X3VA 3HNCA 3S8BA 1PEMA 1PEUA 3TB9A 5R1RA 2WGHA 2CVSA 2F3OA 2XAYA 1XJGA 2EUDA 2CVUA 1XJJA 3O0QA 2CVXA 1XJKA 1R9DA 5FAVA 1ZYZA 1XJFA 1H18A 1CM5A 2CVWA 3PFLA 1L1LA 3S87A 1H7AA 3S8AA 2XAZA 5CNVA 2CVTA 5FAWA 1H16A 1ZZDA 3O0NA 3TBAA 7R1RA 5KDPA 1H17A 1PEQA 2XO5A 2XAVA 3K8TA 1R1RA 2PFLA 1H78A 2X0XA 2CVVA 3HNEA 2XAPA 1XJNA 2XAWA 5FAUA 1H79A 2HA9A 4R1RA 1PEOA 1H7BA 4MTJA 3R1RA 1R8WA 2R1RA 5A0UA 3S8CA
chains in the Genus database with same CATH topology
3HNFA 2BQ1E 2CVYA 2XAXA 5A0ZA 4ERMA 5CNSA 2XO4A 2YAJA 1XJEA 2ZLFA 1XJMA 5CNTA 3O0OA 3HNDA 2XAKA 1RLRA 5FAYA 2ZLGA 2Y8NA 3RSRA 5CNUA 6R1RA 1HK8A 1MZOA 1QHMA 4X3VA 3HNCA 3S8BA 1PEMA 1PEUA 3TB9A 5R1RA 2WGHA 2CVSA 2F3OA 2XAYA 1XJGA 2EUDA 2CVUA 1XJJA 3O0QA 2CVXA 1XJKA 1R9DA 5FAVA 1ZYZA 1XJFA 1H18A 1CM5A 2CVWA 3PFLA 1L1LA 3S87A 1H7AA 3S8AA 2XAZA 5CNVA 2CVTA 5FAWA 1H16A 1ZZDA 3O0NA 3TBAA 7R1RA 5KDPA 1H17A 1PEQA 2XO5A 2XAVA 3K8TA 1R1RA 2PFLA 1H78A 2X0XA 2CVVA 3HNEA 2XAPA 1XJNA 2XAWA 5FAUA 1H79A 2HA9A 4R1RA 1PEOA 1H7BA 4MTJA 3R1RA 1R8WA 2R1RA 5A0UA 3S8CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FAW A;  5FAV A;  5FAU A;  5A0Z A;  5FAY A;  5A0U A;  5KDP A; 
#chains in the Genus database with same CATH topology
 3HNF A;  2BQ1 E;  2CVY A;  2XAX A;  5A0Z A;  4ERM A;  5CNS A;  2XO4 A;  2YAJ A;  1XJE A;  2ZLF A;  1XJM A;  5CNT A;  3O0O A;  3HND A;  2XAK A;  1RLR A;  5FAY A;  2ZLG A;  2Y8N A;  3RSR A;  5CNU A;  6R1R A;  1HK8 A;  1MZO A;  1QHM A;  4X3V A;  3HNC A;  3S8B A;  1PEM A;  1PEU A;  3TB9 A;  5R1R A;  2WGH A;  2CVS A;  2F3O A;  2XAY A;  1XJG A;  2EUD A;  2CVU A;  1XJJ A;  3O0Q A;  2CVX A;  1XJK A;  1R9D A;  5FAV A;  1ZYZ A;  1XJF A;  1H18 A;  1CM5 A;  2CVW A;  3PFL A;  1L1L A;  3S87 A;  1H7A A;  3S8A A;  2XAZ A;  5CNV A;  2CVT A;  5FAW A;  1H16 A;  1ZZD A;  3O0N A;  3TBA A;  7R1R A;  5KDP A;  1H17 A;  1PEQ A;  2XO5 A;  2XAV A;  3K8T A;  1R1R A;  2PFL A;  1H78 A;  2X0X A;  2CVV A;  3HNE A;  2XAP A;  1XJN A;  2XAW A;  5FAU A;  1H79 A;  2HA9 A;  4R1R A;  1PEO A;  1H7B A;  4MTJ A;  3R1R A;  1R8W A;  2R1R A;  5A0U A;  3S8C A; 
#chains in the Genus database with same CATH homology
 3HNF A;  2BQ1 E;  2CVY A;  2XAX A;  5A0Z A;  4ERM A;  5CNS A;  2XO4 A;  2YAJ A;  1XJE A;  2ZLF A;  1XJM A;  5CNT A;  3O0O A;  3HND A;  2XAK A;  1RLR A;  5FAY A;  2ZLG A;  2Y8N A;  3RSR A;  5CNU A;  6R1R A;  1HK8 A;  1MZO A;  1QHM A;  4X3V A;  3HNC A;  3S8B A;  1PEM A;  1PEU A;  3TB9 A;  5R1R A;  2WGH A;  2CVS A;  2F3O A;  2XAY A;  1XJG A;  2EUD A;  2CVU A;  1XJJ A;  3O0Q A;  2CVX A;  1XJK A;  1R9D A;  5FAV A;  1ZYZ A;  1XJF A;  1H18 A;  1CM5 A;  2CVW A;  3PFL A;  1L1L A;  3S87 A;  1H7A A;  3S8A A;  2XAZ A;  5CNV A;  2CVT A;  5FAW A;  1H16 A;  1ZZD A;  3O0N A;  3TBA A;  7R1R A;  5KDP A;  1H17 A;  1PEQ A;  2XO5 A;  2XAV A;  3K8T A;  1R1R A;  2PFL A;  1H78 A;  2X0X A;  2CVV A;  3HNE A;  2XAP A;  1XJN A;  2XAW A;  5FAU A;  1H79 A;  2HA9 A;  4R1R A;  1PEO A;  1H7B A;  4MTJ A;  3R1R A;  1R8W A;  2R1R A;  5A0U A;  3S8C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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