5FAYA

Y208f mutant of choline tma-lyase
Total Genus 345
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
345
sequence length
803
structure length
803
Chain Sequence
GLVPRGSHMGIPDGPTPRHVKLKENFLKQVPSITVQRAVAITKIAKENPGLPKPLLRAKTFRYCCETAPLVIQDHELIVGSPNGAPRAGAFSPEVAWRWLQDELDTIGSRPQDPFYISEEDKKVLREEVFPFWQNKSVDEFCEGQYREADLWEMSGESFVSDCSFHAVNGGGDSNPGYDVILMKKGMLDIQREAREKLEQLDYANPEDIDKIYFYKSVIETAEGVMIYARRLSAYAAELAARETDPRRKAELQKISEVNARVPAHAPSNFWEAIQAVWTVESLLVVEENQTGMSIGRVDQYMYPFYRADIDSGRLTEYEAFDLAGCMLVKMSEMMWITSEGASKFFAGYQPFVNMCVGGVTREGHDATNDLTYMLMDAVRHVRIYQPTLATRVHNKSPQKYLKKIVDVIRSGMGFPAVHFDDAHIKMMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWTSTGYTQWPICIELVLNHGVPLWYGKKVTPDMGDLSQYDTYEKFEAAVKEQIRWITKNTSVATVISQRAHRELAPKPLMSLMYEGCMESGRDVSAGGAMYNFGPGVVWSGLATYVDSMAAIKKLVYDDRKYTLAQLNEALKADFAGYDQILADCLAAPKYGNDDDYADMIAADLVHFTETEHRKYKTLYSVLSHGTLSISNNTPFGQLLGASANGRRAWMPLSDGISPTQGADYKGPTAIIKSVSKMANDNMNIGMVHNFKLMSGLLDTPEGENGLITLIRTACMLGNGEMQFNYLDNELLLDAQKHPEKYRDLVVRVAGYSAFFVELCKDVQDEIISRTMLHGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
pubmed doi rcsb
molecule tags Lyase
source organism Desulfovibrio alaskensis
molecule keywords Choline trimethylamine-lyase
total genus 345
structure length 803
sequence length 803
chains with identical sequence B
ec nomenclature ec 4.3.99.4: Choline trimethylamine-lyase.
pdb deposition date 2015-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01228 Gly_radical Glycine radical
A PF02901 PFL-like Pyruvate formate lyase-like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.20.70.40 Alpha Beta Alpha-Beta Barrel Anaerobic Ribonucleotide-triphosphate Reductase Large Chain Anaerobic Ribonucleotide-triphosphate Reductase Large Chain 5fayA00
5FAUA 5FAVA 5KDPA 5A0UA 5FAWA 5FAYA 5A0ZA
chains in the Genus database with same CATH superfamily
1XJMA 3O0OA 1ZZDA 2XAPA 2CVUA 5A0UA 2XAWA 5CNUA 2X0XA 5A0ZA 3S8BA 5FAUA 7R1RA 3S8AA 2HA9A 2XAVA 2XO5A 5CNSA 5FAWA 5FAYA 1L1LA 3PFLA 1PEQA 4ERMA 2ZLFA 2YAJA 1H17A 2F3OA 2ZLGA 5FAVA 2Y8NA 4X3VA 1H7AA 1XJKA 1RLRA 2XAZA 2R1RA 2CVVA 1QHMA 3HNCA 2CVXA 1PEMA 1R9DA 3HNDA 1H16A 1R1RA 6R1RA 1XJJA 3TB9A 1XJEA 3HNFA 1CM5A 3RSRA 5CNVA 1ZYZA 3HNEA 2CVWA 3TBAA 1XJNA 2PFLA 3S8CA 1MZOA 2XAXA 2XAYA 2BQ1E 1H79A 1XJGA 3O0NA 2CVTA 5R1RA 2CVYA 1PEOA 3S87A 2XO4A 2EUDA 1H78A 4MTJA 2WGHA 2XAKA 1HK8A 1PEUA 1H7BA 1R8WA 3R1RA 4R1RA 1H18A 5KDPA 3O0QA 5CNTA 2CVSA 3K8TA 1XJFA
chains in the Genus database with same CATH topology
1XJMA 3O0OA 1ZZDA 2XAPA 2CVUA 5A0UA 2XAWA 5CNUA 2X0XA 5A0ZA 3S8BA 5FAUA 7R1RA 3S8AA 2HA9A 2XAVA 2XO5A 5CNSA 5FAWA 5FAYA 1L1LA 3PFLA 1PEQA 4ERMA 2ZLFA 2YAJA 1H17A 2F3OA 2ZLGA 5FAVA 2Y8NA 4X3VA 1H7AA 1XJKA 1RLRA 2XAZA 2R1RA 2CVVA 1QHMA 3HNCA 2CVXA 1PEMA 1R9DA 3HNDA 1H16A 1R1RA 6R1RA 1XJJA 3TB9A 1XJEA 3HNFA 1CM5A 3RSRA 5CNVA 1ZYZA 3HNEA 2CVWA 3TBAA 1XJNA 2PFLA 3S8CA 1MZOA 2XAXA 2XAYA 2BQ1E 1H79A 1XJGA 3O0NA 2CVTA 5R1RA 2CVYA 1PEOA 3S87A 2XO4A 2EUDA 1H78A 4MTJA 2WGHA 2XAKA 1HK8A 1PEUA 1H7BA 1R8WA 3R1RA 4R1RA 1H18A 5KDPA 3O0QA 5CNTA 2CVSA 3K8TA 1XJFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FAU A;  5FAV A;  5KDP A;  5A0U A;  5FAW A;  5FAY A;  5A0Z A; 
#chains in the Genus database with same CATH topology
 1XJM A;  3O0O A;  1ZZD A;  2XAP A;  2CVU A;  5A0U A;  2XAW A;  5CNU A;  2X0X A;  5A0Z A;  3S8B A;  5FAU A;  7R1R A;  3S8A A;  2HA9 A;  2XAV A;  2XO5 A;  5CNS A;  5FAW A;  5FAY A;  1L1L A;  3PFL A;  1PEQ A;  4ERM A;  2ZLF A;  2YAJ A;  1H17 A;  2F3O A;  2ZLG A;  5FAV A;  2Y8N A;  4X3V A;  1H7A A;  1XJK A;  1RLR A;  2XAZ A;  2R1R A;  2CVV A;  1QHM A;  3HNC A;  2CVX A;  1PEM A;  1R9D A;  3HND A;  1H16 A;  1R1R A;  6R1R A;  1XJJ A;  3TB9 A;  1XJE A;  3HNF A;  1CM5 A;  3RSR A;  5CNV A;  1ZYZ A;  3HNE A;  2CVW A;  3TBA A;  1XJN A;  2PFL A;  3S8C A;  1MZO A;  2XAX A;  2XAY A;  2BQ1 E;  1H79 A;  1XJG A;  3O0N A;  2CVT A;  5R1R A;  2CVY A;  1PEO A;  3S87 A;  2XO4 A;  2EUD A;  1H78 A;  4MTJ A;  2WGH A;  2XAK A;  1HK8 A;  1PEU A;  1H7B A;  1R8W A;  3R1R A;  4R1R A;  1H18 A;  5KDP A;  3O0Q A;  5CNT A;  2CVS A;  3K8T A;  1XJF A; 
#chains in the Genus database with same CATH homology
 1XJM A;  3O0O A;  1ZZD A;  2XAP A;  2CVU A;  5A0U A;  2XAW A;  5CNU A;  2X0X A;  5A0Z A;  3S8B A;  5FAU A;  7R1R A;  3S8A A;  2HA9 A;  2XAV A;  2XO5 A;  5CNS A;  5FAW A;  5FAY A;  1L1L A;  3PFL A;  1PEQ A;  4ERM A;  2ZLF A;  2YAJ A;  1H17 A;  2F3O A;  2ZLG A;  5FAV A;  2Y8N A;  4X3V A;  1H7A A;  1XJK A;  1RLR A;  2XAZ A;  2R1R A;  2CVV A;  1QHM A;  3HNC A;  2CVX A;  1PEM A;  1R9D A;  3HND A;  1H16 A;  1R1R A;  6R1R A;  1XJJ A;  3TB9 A;  1XJE A;  3HNF A;  1CM5 A;  3RSR A;  5CNV A;  1ZYZ A;  3HNE A;  2CVW A;  3TBA A;  1XJN A;  2PFL A;  3S8C A;  1MZO A;  2XAX A;  2XAY A;  2BQ1 E;  1H79 A;  1XJG A;  3O0N A;  2CVT A;  5R1R A;  2CVY A;  1PEO A;  3S87 A;  2XO4 A;  2EUD A;  1H78 A;  4MTJ A;  2WGH A;  2XAK A;  1HK8 A;  1PEU A;  1H7B A;  1R8W A;  3R1R A;  4R1R A;  1H18 A;  5KDP A;  3O0Q A;  5CNT A;  2CVS A;  3K8T A;  1XJF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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