5J3HE

Human insulin receptor domains l1-cr in complex with peptide s519c16 and 83-7 fv
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
299
structure length
271
Chain Sequence
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDECGDICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKYVIHNNKCIPECPSGYTMNSLLCTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone receptor/immune system
source organism Mus musculus
publication title Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
pubmed doi rcsb
molecule keywords Peptide S519C16
total genus 70
structure length 271
sequence length 299
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2016-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 5j3hE02
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 5j3hE01
3WSQA 3W11E 4KROA 4LEOC 1N8YC 1M6BA 2HR7A 4XSSE 3U9UE 4BSUC 4C8VA 3B2UA 4UFRB 5J3HE 3B2VA 4BSPA 4C99B 4C8WI 4CDKE 4BSSC 4QXFC 1YY9A 4P59A 4HRLC 4C9AB 4LI2B 1IGRA 3P0YA 5SX5M 3I2TA 4OGAE 3NJPA 3U7UA 4BSOA 3H3BA 3P11A 4C9VB 1IVOA 2AHXA 3C09A 4BSRC 3BE1A 5SX4M 4KRPA 4C9RB 4HRMA 4KRLA 3MZWA 2A91A 1S78A 1NQLA 1MOXA 1N8ZC 4C9EB 4XSTE 3WLWA 3QWQA 3LTGA 3LTFA 4UV7A 3N85A 4KNGM 4KRMA 3U2PA 4HRNC 4C9UB 4KT1E
chains in the Genus database with same CATH superfamily
3WSQA 3W11E 4KROA 4LEOC 1N8YC 1M6BA 2HR7A 4XSSE 3U9UE 4BSUC 4C8VA 3B2UA 4UFRB 5J3HE 3B2VA 4BSPA 4C99B 4C8WI 4CDKE 4BSSC 4QXFC 1YY9A 4P59A 4HRLC 4C9AB 4LI2B 1IGRA 3P0YA 5SX5M 3I2TA 4OGAE 3NJPA 3U7UA 4BSOA 3H3BA 3P11A 4C9VB 1IVOA 2AHXA 3C09A 4BSRC 3BE1A 5SX4M 4KRPA 4C9RB 4HRMA 4KRLA 3MZWA 2A91A 1S78A 1NQLA 1MOXA 1N8ZC 4C9EB 4XSTE 3WLWA 3QWQA 3LTGA 3LTFA 4UV7A 3N85A 4KNGM 4KRMA 3U2PA 4HRNC 4C9UB 4KT1E
chains in the Genus database with same CATH topology
3WSQA 3W11E 4KROA 4LEOC 1N8YC 1M6BA 2HR7A 4XSSE 3U9UE 4BSUC 4C8VA 3B2UA 4UFRB 5J3HE 3B2VA 4BSPA 4C99B 4C8WI 4CDKE 4BSSC 4QXFC 1YY9A 4P59A 4HRLC 4C9AB 4LI2B 1IGRA 3P0YA 5SX5M 3I2TA 4OGAE 3NJPA 3U7UA 4BSOA 3H3BA 3P11A 4C9VB 1IVOA 2AHXA 3C09A 4BSRC 3BE1A 5SX4M 4KRPA 4C9RB 4HRMA 4KRLA 3MZWA 2A91A 1S78A 1NQLA 1MOXA 1N8ZC 4C9EB 4XSTE 3WLWA 3QWQA 3LTGA 3LTFA 4UV7A 3N85A 4KNGM 4KRMA 3U2PA 4HRNC 4C9UB 4KT1E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WSQ A;  3W11 E;  4KRO A;  4LEO C;  1N8Y C;  1M6B A;  2HR7 A;  4XSS E;  3U9U E;  4BSU C;  4C8V A;  3B2U A;  4UFR B;  5J3H E;  3B2V A;  4BSP A;  4C99 B;  4C8W I;  4CDK E;  4BSS C;  4QXF C;  1YY9 A;  4P59 A;  4HRL C;  4C9A B;  4LI2 B;  1IGR A;  3P0Y A;  5SX5 M;  3I2T A;  4OGA E;  3NJP A;  3U7U A;  4BSO A;  3H3B A;  3P11 A;  4C9V B;  1IVO A;  2AHX A;  3C09 A;  4BSR C;  3BE1 A;  5SX4 M;  4KRP A;  4C9R B;  4HRM A;  4KRL A;  3MZW A;  2A91 A;  1S78 A;  1NQL A;  1MOX A;  1N8Z C;  4C9E B;  4XST E;  3WLW A;  3QWQ A;  3LTG A;  3LTF A;  4UV7 A;  3N85 A;  4KNG M;  4KRM A;  3U2P A;  4HRN C;  4C9U B;  4KT1 E; 
#chains in the Genus database with same CATH topology
 3WSQ A;  3W11 E;  4KRO A;  4LEO C;  1N8Y C;  1M6B A;  2HR7 A;  4XSS E;  3U9U E;  4BSU C;  4C8V A;  3B2U A;  4UFR B;  5J3H E;  3B2V A;  4BSP A;  4C99 B;  4C8W I;  4CDK E;  4BSS C;  4QXF C;  1YY9 A;  4P59 A;  4HRL C;  4C9A B;  4LI2 B;  1IGR A;  3P0Y A;  5SX5 M;  3I2T A;  4OGA E;  3NJP A;  3U7U A;  4BSO A;  3H3B A;  3P11 A;  4C9V B;  1IVO A;  2AHX A;  3C09 A;  4BSR C;  3BE1 A;  5SX4 M;  4KRP A;  4C9R B;  4HRM A;  4KRL A;  3MZW A;  2A91 A;  1S78 A;  1NQL A;  1MOX A;  1N8Z C;  4C9E B;  4XST E;  3WLW A;  3QWQ A;  3LTG A;  3LTF A;  4UV7 A;  3N85 A;  4KNG M;  4KRM A;  3U2P A;  4HRN C;  4C9U B;  4KT1 E; 
#chains in the Genus database with same CATH homology
 3WSQ A;  3W11 E;  4KRO A;  4LEO C;  1N8Y C;  1M6B A;  2HR7 A;  4XSS E;  3U9U E;  4BSU C;  4C8V A;  3B2U A;  4UFR B;  5J3H E;  3B2V A;  4BSP A;  4C99 B;  4C8W I;  4CDK E;  4BSS C;  4QXF C;  1YY9 A;  4P59 A;  4HRL C;  4C9A B;  4LI2 B;  1IGR A;  3P0Y A;  5SX5 M;  3I2T A;  4OGA E;  3NJP A;  3U7U A;  4BSO A;  3H3B A;  3P11 A;  4C9V B;  1IVO A;  2AHX A;  3C09 A;  4BSR C;  3BE1 A;  5SX4 M;  4KRP A;  4C9R B;  4HRM A;  4KRL A;  3MZW A;  2A91 A;  1S78 A;  1NQL A;  1MOX A;  1N8Z C;  4C9E B;  4XST E;  3WLW A;  3QWQ A;  3LTG A;  3LTF A;  4UV7 A;  3N85 A;  4KNG M;  4KRM A;  3U2P A;  4HRN C;  4C9U B;  4KT1 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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