5J3HE

Human insulin receptor domains l1-cr in complex with peptide s519c16 and 83-7 fv
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
299
structure length
271
Chain Sequence
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDECGDICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKYVIHNNKCIPECPSGYTMNSLLCTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
pubmed doi rcsb
molecule tags Hormone receptor/immune system
source organism Mus musculus
molecule keywords Peptide S519C16
total genus 70
structure length 271
sequence length 299
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2016-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 5j3hE02
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 5j3hE01
4C99B 3P0YA 4KRLA 4OGAE 3P11A 4BSOA 3U9UE 3WSQA 3QWQA 3N85A 3B2UA 1IGRA 3W11E 2HR7A 3U2PA 3MZWA 4LEOC 4BSRC 4LI2B 4C9AB 4C9UB 3C09A 4HRLC 5SX4M 2A91A 1M6BA 4KNGM 3I2TA 4HRMA 3NJPA 4KROA 3B2VA 4QXFC 4UV7A 1N8ZC 3LTGA 3U7UA 1IVOA 4BSPA 1YY9A 4KRMA 4KT1E 3BE1A 4XSTE 5J3HE 4C9VB 5SX5M 3LTFA 4BSUC 4C8WI 4C9RB 2AHXA 4BSSC 4CDKE 3WLWA 1S78A 4C9EB 4KRPA 1NQLA 4C8VA 4HRNC 1MOXA 3H3BA 4UFRB 1N8YC 4P59A 4XSSE
chains in the Genus database with same CATH superfamily
4C99B 3P0YA 4KRLA 4OGAE 3P11A 4BSOA 3U9UE 3WSQA 3QWQA 3N85A 3B2UA 1IGRA 3W11E 2HR7A 3U2PA 3MZWA 4LEOC 4BSRC 4LI2B 4C9AB 4C9UB 3C09A 4HRLC 5SX4M 2A91A 1M6BA 4KNGM 3I2TA 4HRMA 3NJPA 4KROA 3B2VA 4QXFC 4UV7A 1N8ZC 3LTGA 3U7UA 1IVOA 4BSPA 1YY9A 4KRMA 4KT1E 3BE1A 4XSTE 5J3HE 4C9VB 5SX5M 3LTFA 4BSUC 4C8WI 4C9RB 2AHXA 4BSSC 4CDKE 3WLWA 1S78A 4C9EB 4KRPA 1NQLA 4C8VA 4HRNC 1MOXA 3H3BA 4UFRB 1N8YC 4P59A 4XSSE
chains in the Genus database with same CATH topology
4C99B 3P0YA 4KRLA 4OGAE 3P11A 4BSOA 3U9UE 3WSQA 3QWQA 3N85A 3B2UA 1IGRA 3W11E 2HR7A 3U2PA 3MZWA 4LEOC 4BSRC 4LI2B 4C9AB 4C9UB 3C09A 4HRLC 5SX4M 2A91A 1M6BA 4KNGM 3I2TA 4HRMA 3NJPA 4KROA 3B2VA 4QXFC 4UV7A 1N8ZC 3LTGA 3U7UA 1IVOA 4BSPA 1YY9A 4KRMA 4KT1E 3BE1A 4XSTE 5J3HE 4C9VB 5SX5M 3LTFA 4BSUC 4C8WI 4C9RB 2AHXA 4BSSC 4CDKE 3WLWA 1S78A 4C9EB 4KRPA 1NQLA 4C8VA 4HRNC 1MOXA 3H3BA 4UFRB 1N8YC 4P59A 4XSSE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C99 B;  3P0Y A;  4KRL A;  4OGA E;  3P11 A;  4BSO A;  3U9U E;  3WSQ A;  3QWQ A;  3N85 A;  3B2U A;  1IGR A;  3W11 E;  2HR7 A;  3U2P A;  3MZW A;  4LEO C;  4BSR C;  4LI2 B;  4C9A B;  4C9U B;  3C09 A;  4HRL C;  5SX4 M;  2A91 A;  1M6B A;  4KNG M;  3I2T A;  4HRM A;  3NJP A;  4KRO A;  3B2V A;  4QXF C;  4UV7 A;  1N8Z C;  3LTG A;  3U7U A;  1IVO A;  4BSP A;  1YY9 A;  4KRM A;  4KT1 E;  3BE1 A;  4XST E;  5J3H E;  4C9V B;  5SX5 M;  3LTF A;  4BSU C;  4C8W I;  4C9R B;  2AHX A;  4BSS C;  4CDK E;  3WLW A;  1S78 A;  4C9E B;  4KRP A;  1NQL A;  4C8V A;  4HRN C;  1MOX A;  3H3B A;  4UFR B;  1N8Y C;  4P59 A;  4XSS E; 
#chains in the Genus database with same CATH topology
 4C99 B;  3P0Y A;  4KRL A;  4OGA E;  3P11 A;  4BSO A;  3U9U E;  3WSQ A;  3QWQ A;  3N85 A;  3B2U A;  1IGR A;  3W11 E;  2HR7 A;  3U2P A;  3MZW A;  4LEO C;  4BSR C;  4LI2 B;  4C9A B;  4C9U B;  3C09 A;  4HRL C;  5SX4 M;  2A91 A;  1M6B A;  4KNG M;  3I2T A;  4HRM A;  3NJP A;  4KRO A;  3B2V A;  4QXF C;  4UV7 A;  1N8Z C;  3LTG A;  3U7U A;  1IVO A;  4BSP A;  1YY9 A;  4KRM A;  4KT1 E;  3BE1 A;  4XST E;  5J3H E;  4C9V B;  5SX5 M;  3LTF A;  4BSU C;  4C8W I;  4C9R B;  2AHX A;  4BSS C;  4CDK E;  3WLW A;  1S78 A;  4C9E B;  4KRP A;  1NQL A;  4C8V A;  4HRN C;  1MOX A;  3H3B A;  4UFR B;  1N8Y C;  4P59 A;  4XSS E; 
#chains in the Genus database with same CATH homology
 4C99 B;  3P0Y A;  4KRL A;  4OGA E;  3P11 A;  4BSO A;  3U9U E;  3WSQ A;  3QWQ A;  3N85 A;  3B2U A;  1IGR A;  3W11 E;  2HR7 A;  3U2P A;  3MZW A;  4LEO C;  4BSR C;  4LI2 B;  4C9A B;  4C9U B;  3C09 A;  4HRL C;  5SX4 M;  2A91 A;  1M6B A;  4KNG M;  3I2T A;  4HRM A;  3NJP A;  4KRO A;  3B2V A;  4QXF C;  4UV7 A;  1N8Z C;  3LTG A;  3U7U A;  1IVO A;  4BSP A;  1YY9 A;  4KRM A;  4KT1 E;  3BE1 A;  4XST E;  5J3H E;  4C9V B;  5SX5 M;  3LTF A;  4BSU C;  4C8W I;  4C9R B;  2AHX A;  4BSS C;  4CDK E;  3WLW A;  1S78 A;  4C9E B;  4KRP A;  1NQL A;  4C8V A;  4HRN C;  1MOX A;  3H3B A;  4UFR B;  1N8Y C;  4P59 A;  4XSS E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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