3HMSA

Crystal crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Hepatocyte growth factor
publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
source organism Homo sapiens
total genus 26
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmsA00
3SP8A 4APLA 1HKYA 2X2ZA 4A5TS 1NK1A 4Z0FA 5CT1A 3SRIA 3MKPA 3SRJA 4UAOA 5CT3A 3ZLEA 2QJ2A 2J8JA 3HMRA 4R1BA 1I8NA 5CSQA 4R19A 4Z09A 1W8KA 2Q8BA 2Q8AA 1GMNA 2Z8WA 3HMTA 2YIPA 5CS1A 3ZWZA 2Y8RA 5I25A 4UV6A 2YILA 4Z0DA 1W81A 2QJ4A 5CS5A 2J8LA 5EOKA 2HGFA 4IUAA 1BHTA 1GMOA 3HMSA 4R1AA 4R1CA 4APMA 2K13X 2LL4M 5EODA 2LL3A 5CT2A 2YIOA 1GP9A 5COEA 2F83A 5CP9A 1Z40A 5CS3A 5CS9A 4DURA 3HN4A 1YXEA 2Z8VA 4Z0EA
chains in the Genus database with same CATH superfamily
3SP8A 4APLA 1HKYA 2X2ZA 4A5TS 1NK1A 4Z0FA 5CT1A 3SRIA 3MKPA 3SRJA 4UAOA 5CT3A 3ZLEA 2QJ2A 2J8JA 3HMRA 4R1BA 1I8NA 5CSQA 4R19A 4Z09A 1W8KA 2Q8BA 2Q8AA 1GMNA 2Z8WA 3HMTA 4YIVA 2YIPA 5CS1A 3ZWZA 2Y8RA 5I25A 4UV6A 2YILA 4Z0DA 1W81A 4YIZA 2QJ4A 5CS5A 2J8LA 5EOKA 2HGFA 4IUAA 1BHTA 1GMOA 3HMSA 4R1AA 4R1CA 4APMA 2K13X 2LL4M 5EODA 2LL3A 5CT2A 2YIOA 1GP9A 5COEA 2F83A 2KL5A 1Z40A 5CP9A 5CS3A 5CS9A 3HN4A 4DURA 1YXEA 2Z8VA 4Z0EA
chains in the Genus database with same CATH topology
3SP8A 4APLA 1HKYA 2X2ZA 4A5TS 1NK1A 4Z0FA 5CT1A 3SRIA 3MKPA 3SRJA 4UAOA 5CT3A 3ZLEA 2QJ2A 2J8JA 3HMRA 4R1BA 1I8NA 5CSQA 4R19A 4Z09A 1W8KA 2Q8BA 2Q8AA 1GMNA 2Z8WA 3HMTA 4YIVA 2YIPA 5CS1A 3ZWZA 2Y8RA 5I25A 4UV6A 2YILA 4Z0DA 1W81A 4YIZA 2QJ4A 5CS5A 2J8LA 5EOKA 2HGFA 4IUAA 1BHTA 1GMOA 3HMSA 4R1AA 4R1CA 4APMA 2K13X 2LL4M 5EODA 2LL3A 5CT2A 2YIOA 1GP9A 5COEA 2F83A 2KL5A 1Z40A 5CP9A 5CS3A 5CS9A 3HN4A 4DURA 1YXEA 2Z8VA 4Z0EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SP8 A;  4APL A;  1HKY A;  2X2Z A;  4A5T S;  1NK1 A;  4Z0F A;  5CT1 A;  3SRI A;  3MKP A;  3SRJ A;  4UAO A;  5CT3 A;  3ZLE A;  2QJ2 A;  2J8J A;  3HMR A;  4R1B A;  1I8N A;  5CSQ A;  4R19 A;  4Z09 A;  1W8K A;  2Q8B A;  2Q8A A;  1GMN A;  2Z8W A;  3HMT A;  2YIP A;  5CS1 A;  3ZWZ A;  2Y8R A;  5I25 A;  4UV6 A;  2YIL A;  4Z0D A;  1W81 A;  2QJ4 A;  5CS5 A;  2J8L A;  5EOK A;  2HGF A;  4IUA A;  1BHT A;  1GMO A;  3HMS A;  4R1A A;  4R1C A;  4APM A;  2K13 X;  2LL4 M;  5EOD A;  2LL3 A;  5CT2 A;  2YIO A;  1GP9 A;  5COE A;  2F83 A;  5CP9 A;  1Z40 A;  5CS3 A;  5CS9 A;  4DUR A;  3HN4 A;  1YXE A;  2Z8V A;  4Z0E A; 
#chains in the Genus database with same CATH topology
 3SP8 A;  4APL A;  1HKY A;  2X2Z A;  4A5T S;  1NK1 A;  4Z0F A;  5CT1 A;  3SRI A;  3MKP A;  3SRJ A;  4UAO A;  5CT3 A;  3ZLE A;  2QJ2 A;  2J8J A;  3HMR A;  4R1B A;  1I8N A;  5CSQ A;  4R19 A;  4Z09 A;  1W8K A;  2Q8B A;  2Q8A A;  1GMN A;  2Z8W A;  3HMT A;  4YIV A;  2YIP A;  5CS1 A;  3ZWZ A;  2Y8R A;  5I25 A;  4UV6 A;  2YIL A;  4Z0D A;  1W81 A;  4YIZ A;  2QJ4 A;  5CS5 A;  2J8L A;  5EOK A;  2HGF A;  4IUA A;  1BHT A;  1GMO A;  3HMS A;  4R1A A;  4R1C A;  4APM A;  2K13 X;  2LL4 M;  5EOD A;  2LL3 A;  5CT2 A;  2YIO A;  1GP9 A;  5COE A;  2F83 A;  2KL5 A;  1Z40 A;  5CP9 A;  5CS3 A;  5CS9 A;  3HN4 A;  4DUR A;  1YXE A;  2Z8V A;  4Z0E A; 
#chains in the Genus database with same CATH homology
 3SP8 A;  4APL A;  1HKY A;  2X2Z A;  4A5T S;  1NK1 A;  4Z0F A;  5CT1 A;  3SRI A;  3MKP A;  3SRJ A;  4UAO A;  5CT3 A;  3ZLE A;  2QJ2 A;  2J8J A;  3HMR A;  4R1B A;  1I8N A;  5CSQ A;  4R19 A;  4Z09 A;  1W8K A;  2Q8B A;  2Q8A A;  1GMN A;  2Z8W A;  3HMT A;  4YIV A;  2YIP A;  5CS1 A;  3ZWZ A;  2Y8R A;  5I25 A;  4UV6 A;  2YIL A;  4Z0D A;  1W81 A;  4YIZ A;  2QJ4 A;  5CS5 A;  2J8L A;  5EOK A;  2HGF A;  4IUA A;  1BHT A;  1GMO A;  3HMS A;  4R1A A;  4R1C A;  4APM A;  2K13 X;  2LL4 M;  5EOD A;  2LL3 A;  5CT2 A;  2YIO A;  1GP9 A;  5COE A;  2F83 A;  2KL5 A;  1Z40 A;  5CP9 A;  5CS3 A;  5CS9 A;  3HN4 A;  4DUR A;  1YXE A;  2Z8V A;  4Z0E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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