4WLSA

Crystal structure of the metal-free (repressor) form of e. coli cuer, a copper efflux regulator, bound to copa promoter dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
111
structure length
111
Chain Sequence
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription regulator/dna
molecule keywords HTH-type transcriptional regulator CueR
publication title Allosteric transcriptional regulation via changes in the overall topology of the core promoter.
pubmed doi rcsb
source organism Escherichia coli dh5[alpha]
total genus 43
structure length 111
sequence length 111
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00376 MerR MerR family regulatory protein
A PF09278 MerR-DNA-bind MerR, DNA binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1660.10 Mainly Alpha Orthogonal Bundle Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 4wlsA00
4R22B 3D71A 3GP4A 2JMLA 3D6ZA 1Q0AA 4J2NA 3Q1MA 5I44A 2ZHHA 5D8CA 1EXJA 3GPVA 3Q5PA 3D70A 1R8EA 3Q5SA 3Q5RA 1Q08A 3QAOA 5E01A 4WLWA 1R8DA 2DG6A 3UCSA 4WLSA 1EXIA 4R4EA 1Q09A 2VZ4A 4R24B 3D6YA 1Q06A 1JBGA 1Q07A 3HH0A 1Q05A 5I41B 5D90A 2ZHGA 3Q3DA 3IAOA 3Q2YA
chains in the Genus database with same CATH superfamily
4R22B 1RH6A 3D71A 1PM6A 4LHFA 3GP4A 2JMLA 3D6ZA 1Q0AA 4J2NA 3Q1MA 5I44A 2ZHHA 5D8CA 1EXJA 3GPVA 3Q5PA 3EZ2A 3D70A 1R8EA 2KVVA 3Q5SA 3EZFA 1Q08A 3QAOA 5E01A 4WLWA 3Q5RA 1R8DA 2OG0A 2DG6A 3UCSA 4WLSA 1EXIA 4R4EA 3EZ7A 3EZ6A 1Q09A 2VZ4A 1Y6UA 4R24B 1Q06A 3D6YA 4DCZA 1JBGA 3EZ9A 1Q07A 1LX8A 3HH0A 1Q05A 2IEFA 5I41B 5D90A 2ZHGA 3Q3DA 3IAOA 3Q2YA
chains in the Genus database with same CATH topology
4R22B 1RH6A 3D71A 1PM6A 4LHFA 3GP4A 2JMLA 3D6ZA 1Q0AA 4J2NA 3Q1MA 5I44A 2ZHHA 5D8CA 1EXJA 3GPVA 3Q5PA 3EZ2A 3D70A 1R8EA 2KVVA 3Q5SA 3EZFA 1Q08A 3QAOA 5E01A 4WLWA 3Q5RA 1R8DA 2OG0A 2DG6A 3UCSA 4WLSA 1EXIA 4R4EA 3EZ7A 3EZ6A 1Q09A 2VZ4A 1Y6UA 4R24B 1Q06A 3D6YA 4DCZA 1JBGA 3EZ9A 1Q07A 1LX8A 3HH0A 1Q05A 2IEFA 5I41B 5D90A 2ZHGA 3Q3DA 3IAOA 3Q2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4R22 B;  3D71 A;  3GP4 A;  2JML A;  3D6Z A;  1Q0A A;  4J2N A;  3Q1M A;  5I44 A;  2ZHH A;  5D8C A;  1EXJ A;  3GPV A;  3Q5P A;  3D70 A;  1R8E A;  3Q5S A;  3Q5R A;  1Q08 A;  3QAO A;  5E01 A;  4WLW A;  1R8D A;  2DG6 A;  3UCS A;  4WLS A;  1EXI A;  4R4E A;  1Q09 A;  2VZ4 A;  4R24 B;  3D6Y A;  1Q06 A;  1JBG A;  1Q07 A;  3HH0 A;  1Q05 A;  5I41 B;  5D90 A;  2ZHG A;  3Q3D A;  3IAO A;  3Q2Y A; 
#chains in the Genus database with same CATH topology
 4R22 B;  1RH6 A;  3D71 A;  1PM6 A;  4LHF A;  3GP4 A;  2JML A;  3D6Z A;  1Q0A A;  4J2N A;  3Q1M A;  5I44 A;  2ZHH A;  5D8C A;  1EXJ A;  3GPV A;  3Q5P A;  3EZ2 A;  3D70 A;  1R8E A;  2KVV A;  3Q5S A;  3EZF A;  1Q08 A;  3QAO A;  5E01 A;  4WLW A;  3Q5R A;  1R8D A;  2OG0 A;  2DG6 A;  3UCS A;  4WLS A;  1EXI A;  4R4E A;  3EZ7 A;  3EZ6 A;  1Q09 A;  2VZ4 A;  1Y6U A;  4R24 B;  1Q06 A;  3D6Y A;  4DCZ A;  1JBG A;  3EZ9 A;  1Q07 A;  1LX8 A;  3HH0 A;  1Q05 A;  2IEF A;  5I41 B;  5D90 A;  2ZHG A;  3Q3D A;  3IAO A;  3Q2Y A; 
#chains in the Genus database with same CATH homology
 4R22 B;  1RH6 A;  3D71 A;  1PM6 A;  4LHF A;  3GP4 A;  2JML A;  3D6Z A;  1Q0A A;  4J2N A;  3Q1M A;  5I44 A;  2ZHH A;  5D8C A;  1EXJ A;  3GPV A;  3Q5P A;  3EZ2 A;  3D70 A;  1R8E A;  2KVV A;  3Q5S A;  3EZF A;  1Q08 A;  3QAO A;  5E01 A;  4WLW A;  3Q5R A;  1R8D A;  2OG0 A;  2DG6 A;  3UCS A;  4WLS A;  1EXI A;  4R4E A;  3EZ7 A;  3EZ6 A;  1Q09 A;  2VZ4 A;  1Y6U A;  4R24 B;  1Q06 A;  3D6Y A;  4DCZ A;  1JBG A;  3EZ9 A;  1Q07 A;  1LX8 A;  3HH0 A;  1Q05 A;  2IEF A;  5I41 B;  5D90 A;  2ZHG A;  3Q3D A;  3IAO A;  3Q2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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