4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Streptopain
publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
3BB7A 4D8EA 2UZJA 1DKIA 3BBAA 4RKXA 2JTCA 4D8IA 1PVJA 4D8BA
chains in the Genus database with same CATH superfamily
4CDCB 1X9YA 3B79A 2YJCA 5JH3A 1GMYA 3TMPA 3O0UA 1F2CA 2HWKA 5EZSA 1S4VA 4KLBA 4OEMA 4AXMA 3LFYA 1QDQA 2B1MA 3N3KA 3BY4A 3OVXA 1MEGA 2FE8A 3H8CA 4P6EA 4YYQA 1VJVA 2O6XA 1CB5A 5EZQA 1YVBA 3QSDA 8PCHA 2AVWA 2NQIA 2R9OA 2FTDA 2DC6A 1AU0A 4MM3B 3TNXA 3MJ5A 1GCBA 3BPMA 4BOZA 1ZCMA 2OP3A 4QRVA 1U9VA 1PE6A 3KWZA 1CTEA 3P5XA 3S3RA 4K7CA 2R9MA 1U5IA 1AYVA 4A5UA 4Q8GA 4Q8HA 1MDWA 3KW9A 2FYEA 3CBJA 4AXLA 4MSXA 1CS8A 1CPJA 4HWYA 3BC3A 4BOPA 2OULA 2JQGR 1EWMA 5E6JA 1TL9A 3PW3A 1NPZA 2DCBA 1JQPA 2FUDA 3MHHA 3NHEA 4BSQA 1ME4A 4D8IA 2DCCA 3D6SA 4YVAA 4ZUXU 5KO3A 4BOUA 1U9XA 3PDFA 4FIPA 1CVZA 2R9CA 3QJ3A 3RVWA 3AI8A 3V6CA 1ITOA 4N8WA 2VHSA 4GUAA 2AIMA 3MHSA 2F1GA 5EF4A 3PT2A 3IEJA 4YV8A 1AU2A 2DJGB 3HHIA 3MTVA 1HUCB 1MHWA 3K24A 1GECE 3O1GA 2OZ2A 2YJBA 3P5WA 2YJ2A 2GHUA 3E1ZB 1UKFA 4BS5A 3H6SA 2G8EA 2ARYA 2AGAA 1F2AA 4W4UA 4N4ZA 2BU3A 9PAPA 1NLJA 3OQCA 3KKUA 3RVXA 3C0RA 4I04A 4IUMA 4BPVA 7PCKA 2P86A 6PADA 2ACTA 1AU4A 3KFQA 2DC9A 4PI3A 4DMYA 2E02A 3QT4A 3BB7A 2BDZA 1KHPA 1EF7A 3KWBX 1NQCA 2PREA 3USVA 4XZXA 4YYVA 1NL6A 4HXDB 1NB3A 2XU3A 3CH2X 2J7QA 1PPOA 1PPDA 3GCBA 5EGWA 2DCDA 4QRGA 4WA6A 1EWLA 3WXFA 3OISA 2AYOA 3W30A 4WURA 4DMXA 2IBIA 1POPA 3B21A 4PP2E 2DOSA 1BY8A 1GLOA 2B1NA 2PBHA 4MI7A 1BQIA 1DF0A 2G7YA 1SNKA 4FK5A 2Y6EA 4X6HA 5FPWA 1BP4A 1PXVA 3MORA 3IMAA 2FO5A 4BS6A 3MTNA 3ERVA 2FRAA 1Y08A 3PSEA 5CVOB 3W31A 4MZOA 3RVVA 1ME3A 2G6DA 3E9SA 4I07A 3MP2A 3LXSA 3IV2A 2AYNA 4P6GA 2ATOA 4QBBA 5F02A 3KSEA 4PP1A 4RF0A 2AU1A 4IP3A 3IFUA 4RKXA 4W5CA 1QMYA 2J7QC 1BGOA 4PADA 1PCIA 3BBAA 3H7DA 1ICFA 3V6EA 3OVZA 2NQDB 3M99A 3F5VA 3TRKA 4OVZB 4XUIA 3DF0A 2CIOA 3BCNA 1THEA 3P5VA 4D8EA 2PADA 4N79A 3H8BA 1NB5A 3IOQA 1TU6A 2C0YA 1YK7A 3PHUA 1MIRA 1IWDA 4BOQA 3WXEA 4P16A 1YALA 1ZIVA 2WBFX 1XKGA 4BOSA 2DCAA 3N4CA 4OW0A 4XR7A 2HXZA 2Z84A 5JZEA 1CSBB 3CBKA 2JRIA 3PNRA 2JQFR 1DKIA 4QH6A 2H7JA 3BPFA 3PHXA 4MZSA 1Y4HA 1YK8A 3I3TA 3K9MA 4FJCA 2DC7A 4CDFB 1M6DA 4YYSA 1PBHA 4RNAA 1Q6KA 4OELA 1CV8A 2XU5A 2P7UA 3ZUAA 3CH3X 1VSNA 3HHAA 2XU4A 1ATKA 3HD3A 3KX1A 4QRXA 2DZYA 2E01A 4X6JA 3U8EA 1MS6A 1PADA 5J94A 3H89A 2BDLA 1KFXL 3OF8A 2NQAA 4R3DA 1PVJA 1PPNA 2G8JA 4PT5A 3O65A 3PHWA 2YJ9A 4YYWA 2GFOA 3BOWA 2HD5A 2HHNA 2BTWB 4YYUA 5CVNB 4YYRA 1KHQA 2P0RA 1K3BB 3F75A 4REZA 4RY2A 2E03A 3P5UA 2UZJA 3PBHA 2XU1A 4CDDB 4X6IA 2F7DA 3N3GA 2CB5A 2AS8A 3S3QA 2R9NA 3IHPA 2E00A 4M0WA 3ZNHA 4BQVA 2FT2A 2BTWA 1YT7A 4RF1A 4W5BA 2DC8A 2YJ8A 3K8UA 1AIMA 3IUTA 2VHFA 3HWNA 2FQ9A 1F29A 1TLOA 2IPPB 2DZZA 2R6NA 2AUZA 3OF9A 1CQDA 2AUXA 1AU3A 2HH5A 3I06A 4G54A 1EWOA 2PNSA 1O0EA 1CJLA 1EWPA 5CVMA 1U9QX 1FH0A 4CDEB 4D8BA 1YZBA 1STFE 1QOLA 2NQGA 4ZTBA 2JTCA 3C9EA 5K16A 3PRPA 3WXGA 3PRMA 1SP4B 4OVZA 1KFUL 1MEMA 2Y5BA 4I05A 4CZWA 1F2BA 1AECA 5PADA 3RNVA 1A6RA 5CHVA 5A24A 2R9FA 2FRQA 1AYUA 2DJFB 5CHTA 1AYWA 1PIPA 1QXPA 1KXRA 1DEUA 1PPPA 1U9WA 3BWKA 5JA7A
chains in the Genus database with same CATH topology
4RF0A 4R3DA 1PVJA 4IP3A 4PT5A 3O65A 3PHWA 1UKFA 3TMPA 2AGAA 3IFUA 4RKXA 5EZSA 2HWKA 2BTWB 2BU3A 2J7QC 3BY4A 3BBAA 3OQCA 2FE8A 4REZA 3C0RA 4IUMA 5EZQA 2UZJA 3TRKA 4OVZB 4D8EA 4M0WA 3ZNHA 2BTWA 4MM3B 4RF1A 3MJ5A 4BOZA 3BB7A 3PHUA 4XZXA 4BOQA 4P16A 4HXDB 2J7QA 4BOSA 4OW0A 4A5UA 3W30A 4WURA 2Z84A 5JZEA 3B21A 2DOSA 2JRIA 1DKIA 4BOPA 4MI7A 3PHXA 4D8BA 1YZBA 5E6JA 4ZTBA 2JTCA 3PRPA 3PRMA 4OVZA 4RNAA 4D8IA 3RNVA 5KO3A 4BOUA 3PSEA 3W31A 3E9SA 3MP2A 4GUAA 3PT2A 3MTVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BB7 A;  4D8E A;  2UZJ A;  1DKI A;  3BBA A;  4RKX A;  2JTC A;  4D8I A;  1PVJ A;  4D8B A; 
#chains in the Genus database with same CATH topology
 4CDC B;  1X9Y A;  3B79 A;  2YJC A;  5JH3 A;  1GMY A;  3TMP A;  3O0U A;  1F2C A;  2HWK A;  5EZS A;  1S4V A;  4KLB A;  4OEM A;  4AXM A;  3LFY A;  1QDQ A;  2B1M A;  3N3K A;  3BY4 A;  3OVX A;  1MEG A;  2FE8 A;  3H8C A;  4P6E A;  4YYQ A;  1VJV A;  2O6X A;  1CB5 A;  5EZQ A;  1YVB A;  3QSD A;  8PCH A;  2AVW A;  2NQI A;  2R9O A;  2FTD A;  2DC6 A;  1AU0 A;  4MM3 B;  3TNX A;  3MJ5 A;  1GCB A;  3BPM A;  4BOZ A;  1ZCM A;  2OP3 A;  4QRV A;  1U9V A;  1PE6 A;  3KWZ A;  1CTE A;  3P5X A;  3S3R A;  4K7C A;  2R9M A;  1U5I A;  1AYV A;  4A5U A;  4Q8G A;  4Q8H A;  1MDW A;  3KW9 A;  2FYE A;  3CBJ A;  4AXL A;  4MSX A;  1CS8 A;  1CPJ A;  4HWY A;  3BC3 A;  4BOP A;  2OUL A;  2JQG R;  1EWM A;  5E6J A;  1TL9 A;  3PW3 A;  1NPZ A;  2DCB A;  1JQP A;  2FUD A;  3MHH A;  3NHE A;  4BSQ A;  1ME4 A;  4D8I A;  2DCC A;  3D6S A;  4YVA A;  4ZUX U;  5KO3 A;  4BOU A;  1U9X A;  3PDF A;  4FIP A;  1CVZ A;  2R9C A;  3QJ3 A;  3RVW A;  3AI8 A;  3V6C A;  1ITO A;  4N8W A;  2VHS A;  4GUA A;  2AIM A;  3MHS A;  2F1G A;  5EF4 A;  3PT2 A;  3IEJ A;  4YV8 A;  1AU2 A;  2DJG B;  3HHI A;  3MTV A;  1HUC B;  1MHW A;  3K24 A;  1GEC E;  3O1G A;  2OZ2 A;  2YJB A;  3P5W A;  2YJ2 A;  2GHU A;  3E1Z B;  1UKF A;  4BS5 A;  3H6S A;  2G8E A;  2ARY A;  2AGA A;  1F2A A;  4W4U A;  4N4Z A;  2BU3 A;  9PAP A;  1NLJ A;  3OQC A;  3KKU A;  3RVX A;  3C0R A;  4I04 A;  4IUM A;  4BPV A;  7PCK A;  2P86 A;  6PAD A;  2ACT A;  1AU4 A;  3KFQ A;  2DC9 A;  4PI3 A;  4DMY A;  2E02 A;  3QT4 A;  3BB7 A;  2BDZ A;  1KHP A;  1EF7 A;  3KWB X;  1NQC A;  2PRE A;  3USV A;  4XZX A;  4YYV A;  1NL6 A;  4HXD B;  1NB3 A;  2XU3 A;  3CH2 X;  2J7Q A;  1PPO A;  1PPD A;  3GCB A;  5EGW A;  2DCD A;  4QRG A;  4WA6 A;  1EWL A;  3WXF A;  3OIS A;  2AYO A;  3W30 A;  4WUR A;  4DMX A;  2IBI A;  1POP A;  3B21 A;  4PP2 E;  2DOS A;  1BY8 A;  1GLO A;  2B1N A;  2PBH A;  4MI7 A;  1BQI A;  1DF0 A;  2G7Y A;  1SNK A;  4FK5 A;  2Y6E A;  4X6H A;  5FPW A;  1BP4 A;  1PXV A;  3MOR A;  3IMA A;  2FO5 A;  4BS6 A;  3MTN A;  3ERV A;  2FRA A;  1Y08 A;  3PSE A;  5CVO B;  3W31 A;  4MZO A;  3RVV A;  1ME3 A;  2G6D A;  3E9S A;  4I07 A;  3MP2 A;  3LXS A;  3IV2 A;  2AYN A;  4P6G A;  2ATO A;  4QBB A;  5F02 A;  3KSE A;  4PP1 A;  4RF0 A;  2AU1 A;  4IP3 A;  3IFU A;  4RKX A;  4W5C A;  1QMY A;  2J7Q C;  1BGO A;  4PAD A;  1PCI A;  3BBA A;  3H7D A;  1ICF A;  3V6E A;  3OVZ A;  2NQD B;  3M99 A;  3F5V A;  3TRK A;  4OVZ B;  4XUI A;  3DF0 A;  2CIO A;  3BCN A;  1THE A;  3P5V A;  4D8E A;  2PAD A;  4N79 A;  3H8B A;  1NB5 A;  3IOQ A;  1TU6 A;  2C0Y A;  1YK7 A;  3PHU A;  1MIR A;  1IWD A;  4BOQ A;  3WXE A;  4P16 A;  1YAL A;  1ZIV A;  2WBF X;  1XKG A;  4BOS A;  2DCA A;  3N4C A;  4OW0 A;  4XR7 A;  2HXZ A;  2Z84 A;  5JZE A;  1CSB B;  3CBK A;  2JRI A;  3PNR A;  2JQF R;  1DKI A;  4QH6 A;  2H7J A;  3BPF A;  3PHX A;  4MZS A;  1Y4H A;  1YK8 A;  3I3T A;  3K9M A;  4FJC A;  2DC7 A;  4CDF B;  1M6D A;  4YYS A;  1PBH A;  4RNA A;  1Q6K A;  4OEL A;  1CV8 A;  2XU5 A;  2P7U A;  3ZUA A;  3CH3 X;  1VSN A;  3HHA A;  2XU4 A;  1ATK A;  3HD3 A;  3KX1 A;  4QRX A;  2DZY A;  2E01 A;  4X6J A;  3U8E A;  1MS6 A;  1PAD A;  5J94 A;  3H89 A;  2BDL A;  1KFX L;  3OF8 A;  2NQA A;  4R3D A;  1PVJ A;  1PPN A;  2G8J A;  4PT5 A;  3O65 A;  3PHW A;  2YJ9 A;  4YYW A;  2GFO A;  3BOW A;  2HD5 A;  2HHN A;  2BTW B;  4YYU A;  5CVN B;  4YYR A;  1KHQ A;  2P0R A;  1K3B B;  3F75 A;  4REZ A;  4RY2 A;  2E03 A;  3P5U A;  2UZJ A;  3PBH A;  2XU1 A;  4CDD B;  4X6I A;  2F7D A;  3N3G A;  2CB5 A;  2AS8 A;  3S3Q A;  2R9N A;  3IHP A;  2E00 A;  4M0W A;  3ZNH A;  4BQV A;  2FT2 A;  2BTW A;  1YT7 A;  4RF1 A;  4W5B A;  2DC8 A;  2YJ8 A;  3K8U A;  1AIM A;  3IUT A;  2VHF A;  3HWN A;  2FQ9 A;  1F29 A;  1TLO A;  2IPP B;  2DZZ A;  2R6N A;  2AUZ A;  3OF9 A;  1CQD A;  2AUX A;  1AU3 A;  2HH5 A;  3I06 A;  4G54 A;  1EWO A;  2PNS A;  1O0E A;  1CJL A;  1EWP A;  5CVM A;  1U9Q X;  1FH0 A;  4CDE B;  4D8B A;  1YZB A;  1STF E;  1QOL A;  2NQG A;  4ZTB A;  2JTC A;  3C9E A;  5K16 A;  3PRP A;  3WXG A;  3PRM A;  1SP4 B;  4OVZ A;  1KFU L;  1MEM A;  2Y5B A;  4I05 A;  4CZW A;  1F2B A;  1AEC A;  5PAD A;  3RNV A;  1A6R A;  5CHV A;  5A24 A;  2R9F A;  2FRQ A;  1AYU A;  2DJF B;  5CHT A;  1AYW A;  1PIP A;  1QXP A;  1KXR A;  1DEU A;  1PPP A;  1U9W A;  3BWK A;  5JA7 A; 
#chains in the Genus database with same CATH homology
 4RF0 A;  4R3D A;  1PVJ A;  4IP3 A;  4PT5 A;  3O65 A;  3PHW A;  1UKF A;  3TMP A;  2AGA A;  3IFU A;  4RKX A;  5EZS A;  2HWK A;  2BTW B;  2BU3 A;  2J7Q C;  3BY4 A;  3BBA A;  3OQC A;  2FE8 A;  4REZ A;  3C0R A;  4IUM A;  5EZQ A;  2UZJ A;  3TRK A;  4OVZ B;  4D8E A;  4M0W A;  3ZNH A;  2BTW A;  4MM3 B;  4RF1 A;  3MJ5 A;  4BOZ A;  3BB7 A;  3PHU A;  4XZX A;  4BOQ A;  4P16 A;  4HXD B;  2J7Q A;  4BOS A;  4OW0 A;  4A5U A;  3W30 A;  4WUR A;  2Z84 A;  5JZE A;  3B21 A;  2DOS A;  2JRI A;  1DKI A;  4BOP A;  4MI7 A;  3PHX A;  4D8B A;  1YZB A;  5E6J A;  4ZTB A;  2JTC A;  3PRP A;  3PRM A;  4OVZ A;  4RNA A;  4D8I A;  3RNV A;  5KO3 A;  4BOU A;  3PSE A;  3W31 A;  3E9S A;  3MP2 A;  4GUA A;  3PT2 A;  3MTV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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