|
47
|
156
|
7rgjA |
Dfra1 complexed with nadph and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (ucp1223) |
|
42
|
167
|
8f09A |
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (dhfr) enzyme from an uncultured soil bacterium |
|
48
|
164
|
7tj3A |
Crystal structure of a dihydrofolate reductase fola from stenotrophomonas maltophilia bound to nadp and p218 |
|
40
|
161
|
7rebA |
E. coli dihydrofolate reductase complexed with 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (ucp1223) |
|
46
|
157
|
7regA |
Dfra1 complexed with nadph and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (ucp1228) |
|
163
|
608
|
7f3zA |
Double mutant plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts-k1, c59r+s108n) complexed with trimethoprim (top), nadph and dump |
|
167
|
608
|
7f3yA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with methotrexate (mtx), nadph and dump |
|
45
|
164
|
7km8A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001914, orthorhombic crystal from |
|
40
|
163
|
7km9A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001913, tetragonal crystal from |
|
44
|
170
|
7ki9A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001912 |
|
40
|
163
|
7km7A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001914, tetragonal crystal from |
|
42
|
163
|
7ki8A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001580 |
|
44
|
159
|
7d6gA |
Neutron crystal structure of e.coli dihydrofolate reductase complexed with folate and nadp+ at ph4.5 |
|
43
|
159
|
7d4xA |
X-ray crystal structure of e.coli dihydrofolate reductase complexed with folate and nadp+ at ph7.0 |
|
46
|
159
|
7d4lA |
X-ray crystal structure of e.coli dihydrofolate reductase complexed with folate and nadp+ at ph7.0 |
|
41
|
159
|
7d49A |
X-ray crystal structure of e.coli dihydrofolate reductase complexed with folate and nadp+ at ph4.5 |
|
46
|
185
|
7eseA |
The crystal structure of human dhfr from biortus |
|
139
|
602
|
7ctyA |
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts), fragment 263, nadp+, dump |
|
40
|
159
|
7k6cA |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium abscessus atcc 19977 / dsm 44196 with nadp and inhibitor p218 |
|
44
|
159
|
7lvcA |
E. coli dhfr by native mn,p,s-sad at room temperature |
|
43
|
163
|
7k68A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001565 |
|
45
|
165
|
7k62A |
Crystal structure of dihydrofolate reductase from mycobacterium kansasii in complex with nadp and inhibitor p218 |
|
45
|
163
|
7k69A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001574 |
|
45
|
163
|
7k6aA |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor sddc-0001575 |
|
156
|
602
|
6lhiA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with c466 (compound 42) and nadph |
|
167
|
602
|
6lezA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with compound 46 and nadph |
|
150
|
602
|
6lh9A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with compound 46 and nadph |
|
165
|
603
|
6leuA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with compound 42 and nadph |
|
170
|
608
|
6lhjA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with c452 (compound 16) and nadph |
|
168
|
602
|
6levA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with compound 46 and nadph |
|
41
|
163
|
6uwqA |
Crystal structure of dihydrofolate reductase from mycobacterium ulcerans with sddc-0001565 inhibitor |
|
45
|
163
|
6uwwA |
Crystal structure of dihydrofolate reductase from mycobacterium ulcerans with p218 inhibitor |
|
51
|
184
|
6vcjA |
Crystal structure of hsdhfr in complex with nadp+, dap, and r-naproxen |
|
41
|
156
|
7l9tA |
Crystal structure of dihydrofolate reductase from mycolicibacterium smegmatis in complex with sddc-0001565 inhibitor |
|
43
|
159
|
6vs9A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(piperidin-1-ylmethyl)benzoic acid(fragment 11) |
|
38
|
159
|
6vv6A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb113 |
|
42
|
159
|
6vsfA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-4-oxobutanoic acid(fragment 16) |
|
40
|
159
|
6vv7A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb136 |
|
45
|
160
|
6vvbA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 6-methyl-5-(4-phenylthiazol-2-yl)-2- (trifluoromethyl)nicotinic acid (fragment 10) |
|
40
|
159
|
6vs6A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(furan-2-yl)-1-methyl-1h-pyrazole-5-carboxylic acid (fragment 2) |
|
39
|
159
|
6vsdA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-((thiophen-2-ylthio)methyl)benzoic acid (fragment 13) |
|
39
|
159
|
6vv9A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb300 |
|
42
|
159
|
6vsgA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(trifluoromethyl)benzene-1,2-diamine(fragment 17) |
|
40
|
159
|
6vseA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(phenoxymethyl)benzoic acid(fragment 14) |
|
41
|
159
|
6vs5A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1h-pyrazole-4-carboxylic acid (fragment 1) |
|
41
|
159
|
6vs8A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl thiazole-4-carboxylate(fragment 3) |
|
39
|
159
|
6vv8A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb285 |
|
41
|
162
|
6prbA |
S. aureus dihydrofolate reductase co-crystallized with cyclopropyl-dimethyoxydihydropthalazine inhibitor and nadp(h) |
|
41
|
162
|
6pr8A |
S. aureus dihydrofoate reductase co-crystallized with 3,5-dimethylphenyl-dihydropthalazine inhibitor and nadp(h) |
|
42
|
163
|
6praA |
S. aureus dihydrofolate reductase with nadp(h) and empty folate pocket |
