1WERA

Ras-gtpase-activating domain of human p120gap
Total Genus 118

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
324
structure length
324
Chain Sequence
MPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYT
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
pubmed doi rcsb
molecule tags Gtpase activation
source organism Homo sapiens
molecule keywords P120GAP
total genus 118
structure length 324
sequence length 324
ec nomenclature
pdb deposition date 1996-11-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00616 RasGAP GTPase-activator protein for Ras-like GTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.506.10 Mainly Alpha Orthogonal Bundle GTPase Activation - p120GAP; domain 1 GTPase Activation - p120gap; domain 1 1werA01
1.10.506.10 Mainly Alpha Orthogonal Bundle GTPase Activation - p120GAP; domain 1 GTPase Activation - p120gap; domain 1 1werA02
1WQ1G 3HM6X 4M8NA 3BXJA 3IG3A 1WERA 3RYTA 5E6PA 1NF1A 3SU8X 3FAYA 4M8MA
chains in the Genus database with same CATH superfamily
1WQ1G 3HM6X 4M8NA 3BXJA 3IG3A 1WERA 3RYTA 5E6PA 1NF1A 3SU8X 3FAYA 4M8MA
chains in the Genus database with same CATH topology
1WQ1G 3HM6X 4M8NA 3BXJA 3IG3A 1WERA 3RYTA 5E6PA 1NF1A 3SU8X 3FAYA 4M8MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WQ1 G;  3HM6 X;  4M8N A;  3BXJ A;  3IG3 A;  1WER A;  3RYT A;  5E6P A;  1NF1 A;  3SU8 X;  3FAY A;  4M8M A; 
#chains in the Genus database with same CATH topology
 1WQ1 G;  3HM6 X;  4M8N A;  3BXJ A;  3IG3 A;  1WER A;  3RYT A;  5E6P A;  1NF1 A;  3SU8 X;  3FAY A;  4M8M A; 
#chains in the Genus database with same CATH homology
 1WQ1 G;  3HM6 X;  4M8N A;  3BXJ A;  3IG3 A;  1WER A;  3RYT A;  5E6P A;  1NF1 A;  3SU8 X;  3FAY A;  4M8M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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