3S5EA

Crystal structure of human frataxin variant w155r, one of the friedreich's ataxia point mutations
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
121
structure length
121
Chain Sequence
GSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIRLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Unknown function
molecule keywords Frataxin, mitochondrial
publication title Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
pubmed doi rcsb
source organism Homo sapiens
total genus 32
structure length 121
sequence length 121
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3s5eA00
2FQLA 3S5EA 3T3TA 3S4MA 1SOYA 4EC2A 3OEQA 3T3XA 3T3LA 1EKGA 3T3KA 4JPDA 4LP1A 3OERA 3S5FA 3S5DA 2GA5A 4LK8A 1LY7A 4HS5A 1EW4A 2EFFA 3T3JA 2P1XA
chains in the Genus database with same CATH superfamily
2FQLA 3S5EA 3T3TA 3S4MA 1SOYA 4HEA7 3SSDA 4EC2A 3OEQA 1D2MA 3T3XA 3T3LA 3GD0A 1EKGA 1V5RA 3T3KA 4JPDA 3OERA 3A5PA 4LP1A 3S5FA 3IAS7 1WHZA 3IMOA 4P78C 3S5DA 2GA5A 4LK8A 4C26A 3SSCA 1LY7A 3GD9A 1EW4A 4HS5A 2EFFA 3T3JA 3IAM7 2P1XA 3SSEA 3I9V7 2FUG7
chains in the Genus database with same CATH topology
2FQLA 3S5EA 3T3TA 3S4MA 1SOYA 4EC2A 3OEQA 3T3XA 3T3LA 1EKGA 3T3KA 4JPDA 4LP1A 3OERA 3S5FA 3S5DA 2GA5A 4LK8A 1LY7A 4HS5A 1EW4A 2EFFA 3T3JA 2P1XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FQL A;  3S5E A;  3T3T A;  3S4M A;  1SOY A;  4EC2 A;  3OEQ A;  3T3X A;  3T3L A;  1EKG A;  3T3K A;  4JPD A;  4LP1 A;  3OER A;  3S5F A;  3S5D A;  2GA5 A;  4LK8 A;  1LY7 A;  4HS5 A;  1EW4 A;  2EFF A;  3T3J A;  2P1X A; 
#chains in the Genus database with same CATH topology
 2FQL A;  3S5E A;  3T3T A;  3S4M A;  1SOY A;  4HEA 7;  3SSD A;  4EC2 A;  3OEQ A;  1D2M A;  3T3X A;  3T3L A;  3GD0 A;  1EKG A;  1V5R A;  3T3K A;  4JPD A;  3OER A;  3A5P A;  4LP1 A;  3S5F A;  3IAS 7;  1WHZ A;  3IMO A;  4P78 C;  3S5D A;  2GA5 A;  4LK8 A;  4C26 A;  3SSC A;  1LY7 A;  3GD9 A;  1EW4 A;  4HS5 A;  2EFF A;  3T3J A;  3IAM 7;  2P1X A;  3SSE A;  3I9V 7;  2FUG 7; 
#chains in the Genus database with same CATH homology
 2FQL A;  3S5E A;  3T3T A;  3S4M A;  1SOY A;  4EC2 A;  3OEQ A;  3T3X A;  3T3L A;  1EKG A;  3T3K A;  4JPD A;  4LP1 A;  3OER A;  3S5F A;  3S5D A;  2GA5 A;  4LK8 A;  1LY7 A;  4HS5 A;  1EW4 A;  2EFF A;  3T3J A;  2P1X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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