|
19
|
99
|
4u8wA |
Hiv-1 wild type protease with grl-050-10a (a gem-difluoro-bis-tetrahydrofuran as p2-ligand) |
|
91
|
339
|
4s1gA |
Renin in complex with (s)-1-(3-fluoro-5-(((s)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1h)-iminium |
|
106
|
400
|
4rrsA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
78
|
388
|
4trzA |
Structure of bace1 complex with 2-thiophenyl hea-type inhibitor |
|
88
|
339
|
4rycA |
Renin in complexed with 4-methoxy-3-(3-methoxypropoxy)-n-{[(3s,4s)-4-{[(4-methylphenyl)sulfonyl]amino}pyrrolidin-3-yl]methyl}-n-(propan-2-yl)benzamide inhibitor |
|
107
|
390
|
4r8yA |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((r)-1-(2-cyclopentylacetyl)pyrrolidin-3-yl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
18
|
99
|
4qj2A |
Crystal structure of inactive hiv-1 protease variant (i50v/a71v) in complex with wt p1-p6 substrate |
|
17
|
99
|
4qj8A |
Crystal structure of inactive hiv-1 protease variant (i50v/a71v) in complex with p1-p6 substrate variant (p453l) |
|
19
|
99
|
4rvxA |
Crystal structure of multidrug-resistant clinical isolate a02 hiv-1 protease in complex with non-peptidic inhibitor, grl079 |
|
95
|
387
|
4rceA |
Crystal structure of bace1 in complex with aminooxazoline xanthene inhibitor 2 |
|
103
|
390
|
4r95A |
Bace-1 in complex with 2-(((1r,3s)-3-(((r)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium |
|
20
|
99
|
4qj9A |
Crystal structure of inactive hiv-1 protease in complex with p1-p6 substrate variant (r452s) |
|
106
|
390
|
4r91A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3-(cyclopentylamino)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
101
|
388
|
4rcfA |
Crystal structure of bace1 in complex with 2-aminooxazoline 4-fluoroxanthene inhibitor 49 |
|
18
|
99
|
4rvjA |
Crystal structure of multidrug-resistant clinical isolate a02 hiv-1 protease in complex with amprenavir |
|
105
|
389
|
4r93A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-1-methyl-5-oxo-4-(((1s,3r)-3-(3-phenylureido)cyclohexyl)methyl)imidazolidin-2-iminium |
|
17
|
99
|
4rviA |
Crystal structure of multidrug-resistant clinical isolate a02 hiv-1 protease in complex with non-peptidic inhibitor, grl0519 |
|
96
|
387
|
4rcdA |
Crystal structure of bace1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor |
|
84
|
330
|
4rldA |
Crystal structure of kkf mutant of bla g 2 protein |
|
101
|
391
|
4r92A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3-(isonicotinamido)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
106
|
400
|
4r5nA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
18
|
99
|
4qj7A |
Crystal structure of inactive hiv-1 protease variant (i50v/a71v) in complex with p1-p6 substrate variant (r452s) |
|
32
|
128
|
4rghA |
Human dna damage-inducible protein: from protein chemistry and 3d structure to deciphering its cellular role |
|
17
|
99
|
4qj6A |
Crystal structure of inactive hiv-1 protease variant (i50v/a71v) in complex with p1-p6 substrate variant (l449f) |
|
84
|
340
|
4q1nA |
Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors |
|
97
|
406
|
4pphA |
Crystal structure of conglutin gamma, a unique basic 7s globulin from lupine seeds |
|
17
|
99
|
4q1yA |
Mutations outside the active site of hiv-1 protease alter enzyme structure and dynamic ensemble of the active site to confer drug resistance |
|
19
|
99
|
4qgiA |
X-ray crystal structure of hiv-1 protease variant g48t/l89m in complex with saquinavir |
|
107
|
403
|
4pzwA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
15
|
99
|
4phvA |
X-ray crystal structure of the hiv protease complex with l-700,417, an inhibitor with pseudo c2 symmetry |
|
46
|
203
|
4q5mA |
D30n tethered hiv-1 protease dimer/saquinavir complex |
|
18
|
99
|
4q1wA |
Mutations outside the active site of hiv-1 protease alter enzyme structure and dynamic ensemble of the active site to confer drug resistance |
|
77
|
326
|
4pepA |
The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 angstroms resolution |
|
107
|
403
|
4pzxA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
18
|
99
|
4q1xA |
Mutations outside the active site of hiv-1 protease alter enzyme structure and dynamic ensemble of the active site to confer drug resistance |
|
90
|
338
|
4pyvA |
Crystal structure of renin in complex with compound4 |
|
18
|
99
|
4obhA |
Crystal structure of inactive hiv-1 protease in complex with the p1-p6 substrate variant (l449f) |
|
18
|
99
|
4nptA |
Crystal structure of hiv-1 protease multiple mutant p51 complexed with darunavir |
|
16
|
99
|
4obgA |
Crystal structure of nelfinavir-resistant, inactive hiv-1 protease (d30n/n88d) in complex with the p1-p6 substrate. |
|
18
|
99
|
4obkA |
Crystal structure of inactive hiv-1 protease in complex with the p1-p6 substrate variant (l449f/s451n) |
|
14
|
98
|
4oc6A |
Structure of cathepsin d with inhibitor 2-bromo-n-[(2s,3s)-4-{[2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)propanoyl]amino}-3-hydroxy-1-(3-phenoxyphenyl)butan-2-yl]-4,5-dimethoxybenzamide |
|
18
|
99
|
4npuA |
Crystal structure of hiv-1 protease multiple mutant p51 |
|
18
|
99
|
4njtA |
Crystal structure of multidrug-resistant clinical isolate a02 hiv-1 protease in complex with darunavir |
|
17
|
97
|
4obzA |
Structure of cathepsin d with inhibitor 2-(3,4-dimethoxyphenyl)-n-[n-(4-methylbenzyl)carbamimidoyl]acetamide |
|
52
|
243
|
4oc6B |
Structure of cathepsin d with inhibitor 2-bromo-n-[(2s,3s)-4-{[2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)propanoyl]amino}-3-hydroxy-1-(3-phenoxyphenyl)butan-2-yl]-4,5-dimethoxybenzamide |
|
16
|
99
|
4obdA |
Crystal structure of nelfinavir-resistant, inactive hiv-1 protease (d30n/n88d) in complex with the p1-p6 substrate variant (l449f/s451n) |
|
17
|
99
|
4njvA |
Crystal structure of multidrug-resistant clinical isolate a02 hiv-1 protease in complex with ritonavir |
|
14
|
97
|
4od9A |
Structure of cathepsin d with inhibitor n-(3,4-dimethoxybenzyl)-nalpha-{n-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl}-d-phenylalaninamide |
|
105
|
400
|
4n00A |
Discovery of 7-thp chromans: bace1 inhibitors that reduce a-beta in the cns |
|
18
|
99
|
4objA |
Crystal structure of inactive hiv-1 protease in complex with the p1-p6 substrate variant (s451n) |
