1HTLA

Mutation of a buried residue causes lack of activity but no conformational change: crystal structure of e. coli heat-labile enterotoxin mutant val 97--> lys
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
185
structure length
185
Chain Sequence
RLYRADSRPPDEIKRSGGLMPRGHNEYFDRGTQMNINLYDHARGTQTGFVRYDDGYVSTSLSLRSAHLAGQSILSGYSTYYIYVIATAPNMFNKNDVLGVYSPHPYEQEVSALGGIPYSQIYGWYRVNFGVIDERLHRNREYRDRYYRNLNIAPAEDGYRLAGFPPDHQAWREEPWIHHAPQGCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
pubmed doi rcsb
molecule tags Enterotoxin
source organism Escherichia coli
molecule keywords HEAT-LABILE ENTEROTOXIN, SUBUNIT B
total genus 44
structure length 185
sequence length 185
ec nomenclature
pdb deposition date 1995-02-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 1htlA00
2A5FB 1S5DA 1S5CA 2A5DB 2VSAA 1LTBA 1XTCA 2CB6A 1S5EA 1TIIA 1LTSA 2VSEA 1HTLA 1LTAA 1BCPA 2A5GB 2CB4A 1LT4A 1S5BA 1LT3A 1PTOA 1LTGA 1PRTA 1LTTA 4Z9CA 1S5FA 1LTIA 4K6LG
chains in the Genus database with same CATH superfamily
2A5FB 1S5DA 1S5CA 2A5DB 2VSAA 1LTBA 1XTCA 2CB6A 1S5EA 1TIIA 1LTSA 2VSEA 1HTLA 1LTAA 1BCPA 2A5GB 2CB4A 1LT4A 1S5BA 1LT3A 1PTOA 1LTGA 1PRTA 1LTTA 4Z9CA 1S5FA 1LTIA 4K6LG
chains in the Genus database with same CATH topology
2A5FB 1S5DA 1S5CA 2A5DB 2VSAA 1LTBA 1XTCA 2CB6A 1S5EA 1TIIA 1LTSA 2VSEA 1HTLA 1LTAA 1BCPA 2A5GB 2CB4A 1LT4A 1S5BA 1LT3A 1PTOA 1LTGA 1PRTA 1LTTA 4Z9CA 1S5FA 1LTIA 4K6LG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A5F B;  1S5D A;  1S5C A;  2A5D B;  2VSA A;  1LTB A;  1XTC A;  2CB6 A;  1S5E A;  1TII A;  1LTS A;  2VSE A;  1HTL A;  1LTA A;  1BCP A;  2A5G B;  2CB4 A;  1LT4 A;  1S5B A;  1LT3 A;  1PTO A;  1LTG A;  1PRT A;  1LTT A;  4Z9C A;  1S5F A;  1LTI A;  4K6L G; 
#chains in the Genus database with same CATH topology
 2A5F B;  1S5D A;  1S5C A;  2A5D B;  2VSA A;  1LTB A;  1XTC A;  2CB6 A;  1S5E A;  1TII A;  1LTS A;  2VSE A;  1HTL A;  1LTA A;  1BCP A;  2A5G B;  2CB4 A;  1LT4 A;  1S5B A;  1LT3 A;  1PTO A;  1LTG A;  1PRT A;  1LTT A;  4Z9C A;  1S5F A;  1LTI A;  4K6L G; 
#chains in the Genus database with same CATH homology
 2A5F B;  1S5D A;  1S5C A;  2A5D B;  2VSA A;  1LTB A;  1XTC A;  2CB6 A;  1S5E A;  1TII A;  1LTS A;  2VSE A;  1HTL A;  1LTA A;  1BCP A;  2A5G B;  2CB4 A;  1LT4 A;  1S5B A;  1LT3 A;  1PTO A;  1LTG A;  1PRT A;  1LTT A;  4Z9C A;  1S5F A;  1LTI A;  4K6L G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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