2A5FB

Cholera toxin a1 subunit bound to its substrate, nad+, and its human protein activator, arf6
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
185
structure length
185
Chain Sequence
DKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDDQDVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein transport/transferase
molecule keywords ADP-ribosylation factor 6
publication title Structural basis for the activation of cholera toxin by human ARF6-GTP.
pubmed doi rcsb
source organism Homo sapiens
total genus 49
structure length 185
sequence length 185
ec nomenclature ec 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
pdb deposition date 2005-06-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 2a5fB00
2A5DB 2VSEA 1LTSA 2CB4A 1LTGA 1S5EA 2A5GB 1HTLA 1LTTA 1S5DA 1PTOA 1BCPA 1XTCA 1LTBA 2CB6A 2A5FB 2VSAA 1S5CA 1LTIA 4K6LG 1LT4A 1S5FA 1LTAA 4Z9CA 1TIIA 1LT3A 1PRTA 1S5BA
chains in the Genus database with same CATH superfamily
2A5DB 2VSEA 1LTSA 2CB4A 1LTGA 1S5EA 2A5GB 1HTLA 1LTTA 1S5DA 1PTOA 1BCPA 1XTCA 1LTBA 2CB6A 2A5FB 2VSAA 1S5CA 1LTIA 4K6LG 1LT4A 1S5FA 1LTAA 4Z9CA 1TIIA 1LT3A 1PRTA 1S5BA
chains in the Genus database with same CATH topology
2A5DB 2VSEA 1LTSA 2CB4A 1LTGA 1S5EA 2A5GB 1HTLA 1LTTA 1S5DA 1PTOA 1BCPA 1XTCA 1LTBA 2CB6A 2A5FB 2VSAA 1S5CA 1LTIA 4K6LG 1LT4A 1S5FA 1LTAA 4Z9CA 1TIIA 1LT3A 1PRTA 1S5BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A5D B;  2VSE A;  1LTS A;  2CB4 A;  1LTG A;  1S5E A;  2A5G B;  1HTL A;  1LTT A;  1S5D A;  1PTO A;  1BCP A;  1XTC A;  1LTB A;  2CB6 A;  2A5F B;  2VSA A;  1S5C A;  1LTI A;  4K6L G;  1LT4 A;  1S5F A;  1LTA A;  4Z9C A;  1TII A;  1LT3 A;  1PRT A;  1S5B A; 
#chains in the Genus database with same CATH topology
 2A5D B;  2VSE A;  1LTS A;  2CB4 A;  1LTG A;  1S5E A;  2A5G B;  1HTL A;  1LTT A;  1S5D A;  1PTO A;  1BCP A;  1XTC A;  1LTB A;  2CB6 A;  2A5F B;  2VSA A;  1S5C A;  1LTI A;  4K6L G;  1LT4 A;  1S5F A;  1LTA A;  4Z9C A;  1TII A;  1LT3 A;  1PRT A;  1S5B A; 
#chains in the Genus database with same CATH homology
 2A5D B;  2VSE A;  1LTS A;  2CB4 A;  1LTG A;  1S5E A;  2A5G B;  1HTL A;  1LTT A;  1S5D A;  1PTO A;  1BCP A;  1XTC A;  1LTB A;  2CB6 A;  2A5F B;  2VSA A;  1S5C A;  1LTI A;  4K6L G;  1LT4 A;  1S5F A;  1LTA A;  4Z9C A;  1TII A;  1LT3 A;  1PRT A;  1S5B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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