1S5CA

Cholera holotoxin with an a-subunit y30s mutation, crystal form 1
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
234
structure length
216
Chain Sequence
NDDKLYRADSRPPDEIKQSGGLMPRMNINLYDHARGTQGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
pubmed doi rcsb
molecule keywords Cholera enterotoxin, A chain
molecule tags Transferase,toxin
source organism Vibrio cholerae
total genus 57
structure length 216
sequence length 234
ec nomenclature ec 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
pdb deposition date 2004-01-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 1s5cA00
1LTGA 1S5FA 1S5EA 1LT3A 1PTOA 2A5FB 1LTTA 1S5DA 1LTAA 1LTSA 1LT4A 2VSEA 1HTLA 1S5CA 2VSAA 1LTIA 1PRTA 2A5DB 1TIIA 4Z9CA 1XTCA 2CB6A 4K6LG 2CB4A 2A5GB 1LTBA 1S5BA 1BCPA
chains in the Genus database with same CATH superfamily
1LTGA 1S5FA 1S5EA 1LT3A 1PTOA 2A5FB 1LTTA 1S5DA 1LTAA 1LTSA 1LT4A 2VSEA 1HTLA 1S5CA 2VSAA 1LTIA 1PRTA 2A5DB 1TIIA 4Z9CA 1XTCA 2CB6A 4K6LG 2CB4A 2A5GB 1LTBA 1S5BA 1BCPA
chains in the Genus database with same CATH topology
1LTGA 1S5FA 1S5EA 1LT3A 1PTOA 2A5FB 1LTTA 1S5DA 1LTAA 1LTSA 1LT4A 2VSEA 1HTLA 1S5CA 2VSAA 1LTIA 1PRTA 2A5DB 1TIIA 4Z9CA 1XTCA 2CB6A 4K6LG 2CB4A 2A5GB 1LTBA 1S5BA 1BCPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LTG A;  1S5F A;  1S5E A;  1LT3 A;  1PTO A;  2A5F B;  1LTT A;  1S5D A;  1LTA A;  1LTS A;  1LT4 A;  2VSE A;  1HTL A;  1S5C A;  2VSA A;  1LTI A;  1PRT A;  2A5D B;  1TII A;  4Z9C A;  1XTC A;  2CB6 A;  4K6L G;  2CB4 A;  2A5G B;  1LTB A;  1S5B A;  1BCP A; 
#chains in the Genus database with same CATH topology
 1LTG A;  1S5F A;  1S5E A;  1LT3 A;  1PTO A;  2A5F B;  1LTT A;  1S5D A;  1LTA A;  1LTS A;  1LT4 A;  2VSE A;  1HTL A;  1S5C A;  2VSA A;  1LTI A;  1PRT A;  2A5D B;  1TII A;  4Z9C A;  1XTC A;  2CB6 A;  4K6L G;  2CB4 A;  2A5G B;  1LTB A;  1S5B A;  1BCP A; 
#chains in the Genus database with same CATH homology
 1LTG A;  1S5F A;  1S5E A;  1LT3 A;  1PTO A;  2A5F B;  1LTT A;  1S5D A;  1LTA A;  1LTS A;  1LT4 A;  2VSE A;  1HTL A;  1S5C A;  2VSA A;  1LTI A;  1PRT A;  2A5D B;  1TII A;  4Z9C A;  1XTC A;  2CB6 A;  4K6L G;  2CB4 A;  2A5G B;  1LTB A;  1S5B A;  1BCP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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