1S5DA

Cholera holotoxin with an a-subunit y30s mutation, crystal form 2
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
235
structure length
218
Chain Sequence
NDDKLYRADSRPPDEIKQSGGLMPRGQSQMNINLYDHARGTTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
pubmed doi rcsb
molecule tags Transferase,toxin
source organism Vibrio cholerae
molecule keywords Cholera enterotoxin, A chain
total genus 65
structure length 218
sequence length 235
ec nomenclature ec 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
pdb deposition date 2004-01-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 1s5dA00
1LT4A 4K6LG 1S5FA 1S5EA 2A5DB 1HTLA 1LTBA 2CB6A 2CB4A 1LTIA 1PRTA 1XTCA 1LTSA 1LTAA 2VSEA 1TIIA 4Z9CA 1S5BA 2A5GB 2A5FB 1LTGA 1S5CA 1LT3A 1BCPA 1S5DA 1PTOA 2VSAA 1LTTA
chains in the Genus database with same CATH superfamily
1LT4A 4K6LG 1S5FA 1S5EA 2A5DB 1HTLA 1LTBA 2CB6A 2CB4A 1LTIA 1PRTA 1XTCA 1LTSA 1LTAA 2VSEA 1TIIA 4Z9CA 1S5BA 2A5GB 2A5FB 1LTGA 1S5CA 1LT3A 1BCPA 1S5DA 1PTOA 2VSAA 1LTTA
chains in the Genus database with same CATH topology
1LT4A 4K6LG 1S5FA 1S5EA 2A5DB 1HTLA 1LTBA 2CB6A 2CB4A 1LTIA 1PRTA 1XTCA 1LTSA 1LTAA 2VSEA 1TIIA 4Z9CA 1S5BA 2A5GB 2A5FB 1LTGA 1S5CA 1LT3A 1BCPA 1S5DA 1PTOA 2VSAA 1LTTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LT4 A;  4K6L G;  1S5F A;  1S5E A;  2A5D B;  1HTL A;  1LTB A;  2CB6 A;  2CB4 A;  1LTI A;  1PRT A;  1XTC A;  1LTS A;  1LTA A;  2VSE A;  1TII A;  4Z9C A;  1S5B A;  2A5G B;  2A5F B;  1LTG A;  1S5C A;  1LT3 A;  1BCP A;  1S5D A;  1PTO A;  2VSA A;  1LTT A; 
#chains in the Genus database with same CATH topology
 1LT4 A;  4K6L G;  1S5F A;  1S5E A;  2A5D B;  1HTL A;  1LTB A;  2CB6 A;  2CB4 A;  1LTI A;  1PRT A;  1XTC A;  1LTS A;  1LTA A;  2VSE A;  1TII A;  4Z9C A;  1S5B A;  2A5G B;  2A5F B;  1LTG A;  1S5C A;  1LT3 A;  1BCP A;  1S5D A;  1PTO A;  2VSA A;  1LTT A; 
#chains in the Genus database with same CATH homology
 1LT4 A;  4K6L G;  1S5F A;  1S5E A;  2A5D B;  1HTL A;  1LTB A;  2CB6 A;  2CB4 A;  1LTI A;  1PRT A;  1XTC A;  1LTS A;  1LTA A;  2VSE A;  1TII A;  4Z9C A;  1S5B A;  2A5G B;  2A5F B;  1LTG A;  1S5C A;  1LT3 A;  1BCP A;  1S5D A;  1PTO A;  2VSA A;  1LTT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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