1S5FA

Cholera holotoxin, crystal form 2
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
235
structure length
224
Chain Sequence
NDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
pubmed doi rcsb
molecule tags Transferase,toxin
source organism Vibrio cholerae
molecule keywords Cholera enterotoxin, A chain
total genus 58
structure length 224
sequence length 235
ec nomenclature ec 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
pdb deposition date 2004-01-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 1s5fA00
1S5FA 1S5EA 1TIIA 2CB6A 1XTCA 2A5FB 1S5CA 1LTAA 1LT4A 2VSEA 4K6LG 1LTIA 1LT3A 1PRTA 1LTBA 1S5BA 2CB4A 1LTGA 1HTLA 2A5GB 1BCPA 1PTOA 4Z9CA 1LTSA 1S5DA 2VSAA 2A5DB 1LTTA
chains in the Genus database with same CATH superfamily
1S5FA 1S5EA 1TIIA 2CB6A 1XTCA 2A5FB 1S5CA 1LTAA 1LT4A 2VSEA 4K6LG 1LTIA 1LT3A 1PRTA 1LTBA 1S5BA 2CB4A 1LTGA 1HTLA 2A5GB 1BCPA 1PTOA 4Z9CA 1LTSA 1S5DA 2VSAA 2A5DB 1LTTA
chains in the Genus database with same CATH topology
1S5FA 1S5EA 1TIIA 2CB6A 1XTCA 2A5FB 1S5CA 1LTAA 1LT4A 2VSEA 4K6LG 1LTIA 1LT3A 1PRTA 1LTBA 1S5BA 2CB4A 1LTGA 1HTLA 2A5GB 1BCPA 1PTOA 4Z9CA 1LTSA 1S5DA 2VSAA 2A5DB 1LTTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S5F A;  1S5E A;  1TII A;  2CB6 A;  1XTC A;  2A5F B;  1S5C A;  1LTA A;  1LT4 A;  2VSE A;  4K6L G;  1LTI A;  1LT3 A;  1PRT A;  1LTB A;  1S5B A;  2CB4 A;  1LTG A;  1HTL A;  2A5G B;  1BCP A;  1PTO A;  4Z9C A;  1LTS A;  1S5D A;  2VSA A;  2A5D B;  1LTT A; 
#chains in the Genus database with same CATH topology
 1S5F A;  1S5E A;  1TII A;  2CB6 A;  1XTC A;  2A5F B;  1S5C A;  1LTA A;  1LT4 A;  2VSE A;  4K6L G;  1LTI A;  1LT3 A;  1PRT A;  1LTB A;  1S5B A;  2CB4 A;  1LTG A;  1HTL A;  2A5G B;  1BCP A;  1PTO A;  4Z9C A;  1LTS A;  1S5D A;  2VSA A;  2A5D B;  1LTT A; 
#chains in the Genus database with same CATH homology
 1S5F A;  1S5E A;  1TII A;  2CB6 A;  1XTC A;  2A5F B;  1S5C A;  1LTA A;  1LT4 A;  2VSE A;  4K6L G;  1LTI A;  1LT3 A;  1PRT A;  1LTB A;  1S5B A;  2CB4 A;  1LTG A;  1HTL A;  2A5G B;  1BCP A;  1PTO A;  4Z9C A;  1LTS A;  1S5D A;  2VSA A;  2A5D B;  1LTT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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