2QYPA

Orthorhombic crystal structure of human saposin c dimer in open conformation
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
78
structure length
78
Chain Sequence
SDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.
pubmed doi rcsb
molecule keywords Proactivator polypeptide
molecule tags Lipid binding protein
source organism Homo sapiens
total genus 21
structure length 78
sequence length 78
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03489 SapB_2 Saposin-like type B, region 2
A PF05184 SapB_1 Saposin-like type B, region 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 2qypA00
4UEXA 1OF9A 2RB3A 1M12A 1SN6A 2QYPA 2RQYA 3BQQA 2W51A 4BITA 3S64A 1NKLA 2R0RA 3BQPA 4DDJA 1L9LA 2W50A 2KVDA 2R1QA 2LPNA 2Z9AA 2JS9A 4V2OA 3RFIA 2JSAA 2DOBA 1QDMA 3S63A 2GTGA 1N69A
chains in the Genus database with same CATH superfamily
4UEXA 1OF9A 2RB3A 1M12A 1SN6A 2JQ3A 2QYPA 2RQYA 3BQQA 2W51A 4BITA 3S64A 1NKLA 2R0RA 3BQPA 3EUKE 4DDJA 1L9LA 2W50A 2KVDA 2R1QA 2LPNA 2Z9AA 2JS9A 4V2OA 3RFIA 2JSAA 2DOBA 1QDMA 3S63A 3EUJB 3CJLA 2GTGA 1N69A
chains in the Genus database with same CATH topology
4UEXA 1OF9A 2RB3A 1M12A 1SN6A 2QYPA 2RQYA 3BQQA 2W51A 4BITA 3S64A 1NKLA 2R0RA 3BQPA 4DDJA 1L9LA 2W50A 2KVDA 2R1QA 2LPNA 2Z9AA 2JS9A 4V2OA 3RFIA 2JSAA 2DOBA 1QDMA 3S63A 2GTGA 1N69A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UEX A;  1OF9 A;  2RB3 A;  1M12 A;  1SN6 A;  2QYP A;  2RQY A;  3BQQ A;  2W51 A;  4BIT A;  3S64 A;  1NKL A;  2R0R A;  3BQP A;  4DDJ A;  1L9L A;  2W50 A;  2KVD A;  2R1Q A;  2LPN A;  2Z9A A;  2JS9 A;  4V2O A;  3RFI A;  2JSA A;  2DOB A;  1QDM A;  3S63 A;  2GTG A;  1N69 A; 
#chains in the Genus database with same CATH topology
 4UEX A;  1OF9 A;  2RB3 A;  1M12 A;  1SN6 A;  2JQ3 A;  2QYP A;  2RQY A;  3BQQ A;  2W51 A;  4BIT A;  3S64 A;  1NKL A;  2R0R A;  3BQP A;  3EUK E;  4DDJ A;  1L9L A;  2W50 A;  2KVD A;  2R1Q A;  2LPN A;  2Z9A A;  2JS9 A;  4V2O A;  3RFI A;  2JSA A;  2DOB A;  1QDM A;  3S63 A;  3EUJ B;  3CJL A;  2GTG A;  1N69 A; 
#chains in the Genus database with same CATH homology
 4UEX A;  1OF9 A;  2RB3 A;  1M12 A;  1SN6 A;  2QYP A;  2RQY A;  3BQQ A;  2W51 A;  4BIT A;  3S64 A;  1NKL A;  2R0R A;  3BQP A;  4DDJ A;  1L9L A;  2W50 A;  2KVD A;  2R1Q A;  2LPN A;  2Z9A A;  2JS9 A;  4V2O A;  3RFI A;  2JSA A;  2DOB A;  1QDM A;  3S63 A;  2GTG A;  1N69 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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