2Z9AA

Crystal structure of human saposin c dimer in open conformation
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
77
structure length
77
Chain Sequence
DVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.
pubmed doi rcsb
molecule tags Lipid binding protein
source organism Homo sapiens
molecule keywords Proactivator polypeptide
total genus 26
structure length 77
sequence length 77
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03489 SapB_2 Saposin-like type B, region 2
A PF05184 SapB_1 Saposin-like type B, region 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 2z9aA00
1SN6A 2JSAA 2RB3A 2Z9AA 2JS9A 1NKLA 1M12A 3S63A 2R0RA 2W50A 2RQYA 3BQPA 3RFIA 2QYPA 2DOBA 1QDMA 2GTGA 4BITA 4V2OA 2W51A 1N69A 3S64A 3BQQA 1L9LA 1OF9A 2KVDA 2R1QA 2LPNA 4UEXA 4DDJA
chains in the Genus database with same CATH superfamily
3CJLA 1SN6A 2JSAA 2RB3A 2JQ3A 2Z9AA 2JS9A 1NKLA 1M12A 3S63A 2R0RA 3EUJB 2W50A 2RQYA 3BQPA 3RFIA 2QYPA 2DOBA 1QDMA 2GTGA 4BITA 4V2OA 1N69A 2W51A 3S64A 3BQQA 1L9LA 1OF9A 2KVDA 3EUKE 2R1QA 2LPNA 4UEXA 4DDJA
chains in the Genus database with same CATH topology
1SN6A 2JSAA 2RB3A 2Z9AA 2JS9A 1NKLA 1M12A 3S63A 2R0RA 2W50A 2RQYA 3BQPA 3RFIA 2QYPA 2DOBA 1QDMA 2GTGA 4BITA 4V2OA 2W51A 1N69A 3S64A 3BQQA 1L9LA 1OF9A 2KVDA 2R1QA 2LPNA 4UEXA 4DDJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SN6 A;  2JSA A;  2RB3 A;  2Z9A A;  2JS9 A;  1NKL A;  1M12 A;  3S63 A;  2R0R A;  2W50 A;  2RQY A;  3BQP A;  3RFI A;  2QYP A;  2DOB A;  1QDM A;  2GTG A;  4BIT A;  4V2O A;  2W51 A;  1N69 A;  3S64 A;  3BQQ A;  1L9L A;  1OF9 A;  2KVD A;  2R1Q A;  2LPN A;  4UEX A;  4DDJ A; 
#chains in the Genus database with same CATH topology
 3CJL A;  1SN6 A;  2JSA A;  2RB3 A;  2JQ3 A;  2Z9A A;  2JS9 A;  1NKL A;  1M12 A;  3S63 A;  2R0R A;  3EUJ B;  2W50 A;  2RQY A;  3BQP A;  3RFI A;  2QYP A;  2DOB A;  1QDM A;  2GTG A;  4BIT A;  4V2O A;  1N69 A;  2W51 A;  3S64 A;  3BQQ A;  1L9L A;  1OF9 A;  2KVD A;  3EUK E;  2R1Q A;  2LPN A;  4UEX A;  4DDJ A; 
#chains in the Genus database with same CATH homology
 1SN6 A;  2JSA A;  2RB3 A;  2Z9A A;  2JS9 A;  1NKL A;  1M12 A;  3S63 A;  2R0R A;  2W50 A;  2RQY A;  3BQP A;  3RFI A;  2QYP A;  2DOB A;  1QDM A;  2GTG A;  4BIT A;  4V2O A;  2W51 A;  1N69 A;  3S64 A;  3BQQ A;  1L9L A;  1OF9 A;  2KVD A;  2R1Q A;  2LPN A;  4UEX A;  4DDJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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