4HTOA

Crystal structure of the dbd domain of human dna ligase iv apo form
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
223
structure length
214
Chain Sequence
SQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining.
pubmed doi rcsb
molecule tags Ligase, dna binding protein
source organism Homo sapiens
molecule keywords DNA ligase 4
total genus 73
structure length 214
sequence length 223
ec nomenclature ec 6.5.1.1: DNA ligase (ATP).
pdb deposition date 2012-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04675 DNA_ligase_A_N DNA ligase N terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3260.10 Mainly Alpha Orthogonal Bundle DNA ligase i, domain 1 DNA ligase, ATP-dependent, N-terminal domain 4htoA00
3GDEA 3L2PA 4HTOA 3RR5A 4HTPA 3W1BA 4EQ5A 3W5OA 2HIVA 1X9NA 3W1GA 2CFMA 2HIXA
chains in the Genus database with same CATH superfamily
3GDEA 3L2PA 4HTOA 3RR5A 4HTPA 3W1BA 4EQ5A 3W5OA 2HIVA 1X9NA 3W1GA 2CFMA 2HIXA
chains in the Genus database with same CATH topology
3GDEA 3L2PA 4HTOA 3RR5A 4HTPA 3W1BA 4EQ5A 3W5OA 2HIVA 1X9NA 3W1GA 2CFMA 2HIXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GDE A;  3L2P A;  4HTO A;  3RR5 A;  4HTP A;  3W1B A;  4EQ5 A;  3W5O A;  2HIV A;  1X9N A;  3W1G A;  2CFM A;  2HIX A; 
#chains in the Genus database with same CATH topology
 3GDE A;  3L2P A;  4HTO A;  3RR5 A;  4HTP A;  3W1B A;  4EQ5 A;  3W5O A;  2HIV A;  1X9N A;  3W1G A;  2CFM A;  2HIX A; 
#chains in the Genus database with same CATH homology
 3GDE A;  3L2P A;  4HTO A;  3RR5 A;  4HTP A;  3W1B A;  4EQ5 A;  3W5O A;  2HIV A;  1X9N A;  3W1G A;  2CFM A;  2HIX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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