4V2OA

Structure of saposin b in complex with chloroquine
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
78
structure length
78
Chain Sequence
GDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Lysosomal Protein Saposin B Binds Chloroquine.
pubmed doi rcsb
molecule tags Hydrolase activator
source organism Homo sapiens
molecule keywords SAPOSIN-B
total genus 28
structure length 78
sequence length 78
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03489 SapB_2 Saposin-like type B, region 2
A PF05184 SapB_1 Saposin-like type B, region 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 4v2oA00
2RB3A 4DDJA 3S63A 4BITA 2Z9AA 2QYPA 2KVDA 2LPNA 2W50A 1M12A 1SN6A 3S64A 2DOBA 4UEXA 2JSAA 1L9LA 4V2OA 2RQYA 3BQQA 2R0RA 1N69A 1QDMA 2GTGA 2W51A 1NKLA 3RFIA 3BQPA 2R1QA 1OF9A 2JS9A
chains in the Genus database with same CATH superfamily
2RB3A 4DDJA 3S63A 4BITA 2Z9AA 3CJLA 2QYPA 2KVDA 2LPNA 2W50A 1M12A 1SN6A 3S64A 2DOBA 4UEXA 2JSAA 1L9LA 4V2OA 2RQYA 3BQQA 2R0RA 1N69A 1QDMA 2JQ3A 2GTGA 2W51A 1NKLA 3RFIA 3BQPA 3EUKE 2R1QA 3EUJB 1OF9A 2JS9A
chains in the Genus database with same CATH topology
2RB3A 4DDJA 3S63A 4BITA 2Z9AA 2QYPA 2KVDA 2LPNA 2W50A 1M12A 1SN6A 3S64A 2DOBA 4UEXA 2JSAA 1L9LA 4V2OA 2RQYA 3BQQA 2R0RA 1N69A 1QDMA 2GTGA 2W51A 1NKLA 3RFIA 3BQPA 2R1QA 1OF9A 2JS9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RB3 A;  4DDJ A;  3S63 A;  4BIT A;  2Z9A A;  2QYP A;  2KVD A;  2LPN A;  2W50 A;  1M12 A;  1SN6 A;  3S64 A;  2DOB A;  4UEX A;  2JSA A;  1L9L A;  4V2O A;  2RQY A;  3BQQ A;  2R0R A;  1N69 A;  1QDM A;  2GTG A;  2W51 A;  1NKL A;  3RFI A;  3BQP A;  2R1Q A;  1OF9 A;  2JS9 A; 
#chains in the Genus database with same CATH topology
 2RB3 A;  4DDJ A;  3S63 A;  4BIT A;  2Z9A A;  3CJL A;  2QYP A;  2KVD A;  2LPN A;  2W50 A;  1M12 A;  1SN6 A;  3S64 A;  2DOB A;  4UEX A;  2JSA A;  1L9L A;  4V2O A;  2RQY A;  3BQQ A;  2R0R A;  1N69 A;  1QDM A;  2JQ3 A;  2GTG A;  2W51 A;  1NKL A;  3RFI A;  3BQP A;  3EUK E;  2R1Q A;  3EUJ B;  1OF9 A;  2JS9 A; 
#chains in the Genus database with same CATH homology
 2RB3 A;  4DDJ A;  3S63 A;  4BIT A;  2Z9A A;  2QYP A;  2KVD A;  2LPN A;  2W50 A;  1M12 A;  1SN6 A;  3S64 A;  2DOB A;  4UEX A;  2JSA A;  1L9L A;  4V2O A;  2RQY A;  3BQQ A;  2R0R A;  1N69 A;  1QDM A;  2GTG A;  2W51 A;  1NKL A;  3RFI A;  3BQP A;  2R1Q A;  1OF9 A;  2JS9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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