4EWSA

Crystal structure of cholesteryl ester transfer protein in complex with inhibitors
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
472
structure length
472
Chain Sequence
TSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQDVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTADSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKDVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVDSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESIQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lipid transport/inhibitor
molecule keywords CETP
publication title Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 126
structure length 472
sequence length 472
ec nomenclature
pdb deposition date 2012-04-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01273 LBP_BPI_CETP LBP / BPI / CETP family, N-terminal domain
A PF02886 LBP_BPI_CETP_C LBP / BPI / CETP family, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.15.10.10 Alpha Beta Super Roll Bactericidal permeability-increasing protein; domain 1 Bactericidal permeability-increasing protein; domain 1 4ewsA02
3.15.20.10 Alpha Beta Super Roll Bactericidal permeability-increasing protein; domain 2 Bactericidal permeability-increasing protein; domain 2 4ewsA01
4F2AA 4M4DA 4KGOA 5I7LA 5I7JA 4EWSA 4KGHA 3ZPMA 1EWFA 2OBDA 1BP1A 5I7KA
chains in the Genus database with same CATH superfamily
3A1ZA 4KGOA 5I7LA 3N72A 3AOSA 3E8WA 1EWFA 2OBDA 1BP1A 5I7JA 4M4DA 3UV1A 3E8TA 1USVB 4KGHA 3ZPMA 4G0SA 3L6IA 4F2AA 2RCKA 1USUB 3H4ZA 4EWSA 3AOTA 5I7KA 2RQFA
chains in the Genus database with same CATH topology
3A1ZA 4KGOA 5I7LA 3N72A 3AOSA 3E8WA 1EWFA 2OBDA 1BP1A 5I7JA 4M4DA 3UV1A 3E8TA 1USVB 4KGHA 3ZPMA 4G0SA 3L6IA 4F2AA 2RCKA 1USUB 3H4ZA 4EWSA 3AOTA 5I7KA 2RQFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F2A A;  4M4D A;  4KGO A;  5I7L A;  5I7J A;  4EWS A;  4KGH A;  3ZPM A;  1EWF A;  2OBD A;  1BP1 A;  5I7K A; 
#chains in the Genus database with same CATH topology
 3A1Z A;  4KGO A;  5I7L A;  3N72 A;  3AOS A;  3E8W A;  1EWF A;  2OBD A;  1BP1 A;  5I7J A;  4M4D A;  3UV1 A;  3E8T A;  1USV B;  4KGH A;  3ZPM A;  4G0S A;  3L6I A;  4F2A A;  2RCK A;  1USU B;  3H4Z A;  4EWS A;  3AOT A;  5I7K A;  2RQF A; 
#chains in the Genus database with same CATH homology
 3A1Z A;  4KGO A;  5I7L A;  3N72 A;  3AOS A;  3E8W A;  1EWF A;  2OBD A;  1BP1 A;  5I7J A;  4M4D A;  3UV1 A;  3E8T A;  1USV B;  4KGH A;  3ZPM A;  4G0S A;  3L6I A;  4F2A A;  2RCK A;  1USU B;  3H4Z A;  4EWS A;  3AOT A;  5I7K A;  2RQF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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