1JOUA

Crystal structure of native s195a thrombin with an unoccupied active site
Total Genus 4
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
4
sequence length
45
structure length
45
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Blood clotting
molecule keywords Thrombin, light chain
publication title The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
pubmed doi rcsb
source organism Homo sapiens
total genus 4
structure length 45
sequence length 45
chains with identical sequence C, E
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2001-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1jouA00
1A0HA 1TB6L 2PV9A 1JOUA 3EDXA 1JMOL 3HK6A 3GISA 3LU9A 2PUXA 3BEFA 1AVGL 2A1DA 3HKIA 4RKOA 3BEIA 2ODYA 4DY7A 1Z8JA 1TQ7A 2PGQA 1TBRJ 2B5TA 3E6PL 1TBQJ 3B9FL
chains in the Genus database with same CATH superfamily
1A0HA 1TB6L 2PV9A 1JOUA 3EDXA 1JMOL 3HK6A 3GISA 3LU9A 2PUXA 3BEFA 1AVGL 2A1DA 3HKIA 4RKOA 3BEIA 2ODYA 4DY7A 1Z8JA 1TQ7A 2PGQA 1TBRJ 2B5TA 3E6PL 1TBQJ 3B9FL
chains in the Genus database with same CATH topology
1A0HA 1TB6L 2PV9A 1JOUA 3EDXA 1JMOL 3HK6A 3GISA 3LU9A 2PUXA 3BEFA 1AVGL 2A1DA 3HKIA 4RKOA 3BEIA 2ODYA 4DY7A 1Z8JA 1TQ7A 2PGQA 1TBRJ 2B5TA 3E6PL 1TBQJ 3B9FL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A0H A;  1TB6 L;  2PV9 A;  1JOU A;  3EDX A;  1JMO L;  3HK6 A;  3GIS A;  3LU9 A;  2PUX A;  3BEF A;  1AVG L;  2A1D A;  3HKI A;  4RKO A;  3BEI A;  2ODY A;  4DY7 A;  1Z8J A;  1TQ7 A;  2PGQ A;  1TBR J;  2B5T A;  3E6P L;  1TBQ J;  3B9F L; 
#chains in the Genus database with same CATH topology
 1A0H A;  1TB6 L;  2PV9 A;  1JOU A;  3EDX A;  1JMO L;  3HK6 A;  3GIS A;  3LU9 A;  2PUX A;  3BEF A;  1AVG L;  2A1D A;  3HKI A;  4RKO A;  3BEI A;  2ODY A;  4DY7 A;  1Z8J A;  1TQ7 A;  2PGQ A;  1TBR J;  2B5T A;  3E6P L;  1TBQ J;  3B9F L; 
#chains in the Genus database with same CATH homology
 1A0H A;  1TB6 L;  2PV9 A;  1JOU A;  3EDX A;  1JMO L;  3HK6 A;  3GIS A;  3LU9 A;  2PUX A;  3BEF A;  1AVG L;  2A1D A;  3HKI A;  4RKO A;  3BEI A;  2ODY A;  4DY7 A;  1Z8J A;  1TQ7 A;  2PGQ A;  1TBR J;  2B5T A;  3E6P L;  1TBQ J;  3B9F L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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