1TB6L

2.5a crystal structure of the antithrombin-thrombin-heparin ternary complex
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/blood clotting
molecule keywords thrombin
publication title Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2004-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1tb6L00
2PGQA 3HK6A 1TB6L 1A0HA 4DY7A 1AVGL 3LU9A 3BEIA 2PUXA 3B9FL 1JOUA 1Z8JA 1TBRJ 2ODYA 3HKIA 3EDXA 3GISA 2A1DA 2B5TA 1TQ7A 3E6PL 3BEFA 1JMOL 1TBQJ 2PV9A 4RKOA
chains in the Genus database with same CATH superfamily
2PGQA 3HK6A 1TB6L 1A0HA 4DY7A 1AVGL 3LU9A 3BEIA 2PUXA 3B9FL 1JOUA 1Z8JA 1TBRJ 2ODYA 3HKIA 3EDXA 3GISA 2A1DA 2B5TA 1TQ7A 3E6PL 3BEFA 1JMOL 1TBQJ 2PV9A 4RKOA
chains in the Genus database with same CATH topology
2PGQA 3HK6A 1TB6L 1A0HA 4DY7A 1AVGL 3LU9A 3BEIA 2PUXA 3B9FL 1JOUA 1Z8JA 1TBRJ 2ODYA 3HKIA 3EDXA 3GISA 2A1DA 2B5TA 1TQ7A 3E6PL 3BEFA 1JMOL 1TBQJ 2PV9A 4RKOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PGQ A;  3HK6 A;  1TB6 L;  1A0H A;  4DY7 A;  1AVG L;  3LU9 A;  3BEI A;  2PUX A;  3B9F L;  1JOU A;  1Z8J A;  1TBR J;  2ODY A;  3HKI A;  3EDX A;  3GIS A;  2A1D A;  2B5T A;  1TQ7 A;  3E6P L;  3BEF A;  1JMO L;  1TBQ J;  2PV9 A;  4RKO A; 
#chains in the Genus database with same CATH topology
 2PGQ A;  3HK6 A;  1TB6 L;  1A0H A;  4DY7 A;  1AVG L;  3LU9 A;  3BEI A;  2PUX A;  3B9F L;  1JOU A;  1Z8J A;  1TBR J;  2ODY A;  3HKI A;  3EDX A;  3GIS A;  2A1D A;  2B5T A;  1TQ7 A;  3E6P L;  3BEF A;  1JMO L;  1TBQ J;  2PV9 A;  4RKO A; 
#chains in the Genus database with same CATH homology
 2PGQ A;  3HK6 A;  1TB6 L;  1A0H A;  4DY7 A;  1AVG L;  3LU9 A;  3BEI A;  2PUX A;  3B9F L;  1JOU A;  1Z8J A;  1TBR J;  2ODY A;  3HKI A;  3EDX A;  3GIS A;  2A1D A;  2B5T A;  1TQ7 A;  3E6P L;  3BEF A;  1JMO L;  1TBQ J;  2PV9 A;  4RKO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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