3HK6A

Crystal structure of murine thrombin mutant w215a/e217a (two molecules in the asymmetric unit)
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
FHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Thrombin light chain
publication title Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
pubmed doi rcsb
source organism Mus musculus
total genus 3
structure length 43
sequence length 43
chains with identical sequence C
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2009-05-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3hk6A00
2PV9A 2B5TA 2ODYA 1Z8JA 1TB6L 1A0HA 1JMOL 3HK6A 4RKOA 4DY7A 3BEFA 1TQ7A 1TBRJ 2A1DA 3GISA 3BEIA 3EDXA 3LU9A 2PUXA 3B9FL 2PGQA 1TBQJ 1JOUA 3HKIA 1AVGL 3E6PL
chains in the Genus database with same CATH superfamily
2PV9A 2B5TA 2ODYA 1Z8JA 1TB6L 1A0HA 1JMOL 3HK6A 4RKOA 4DY7A 3BEFA 1TQ7A 1TBRJ 2A1DA 3GISA 3BEIA 3EDXA 3LU9A 2PUXA 3B9FL 2PGQA 1TBQJ 1JOUA 3HKIA 1AVGL 3E6PL
chains in the Genus database with same CATH topology
2PV9A 2B5TA 2ODYA 1Z8JA 1TB6L 1A0HA 1JMOL 3HK6A 4RKOA 4DY7A 3BEFA 1TQ7A 1TBRJ 2A1DA 3GISA 3BEIA 3EDXA 3LU9A 2PUXA 3B9FL 2PGQA 1TBQJ 1JOUA 3HKIA 1AVGL 3E6PL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PV9 A;  2B5T A;  2ODY A;  1Z8J A;  1TB6 L;  1A0H A;  1JMO L;  3HK6 A;  4RKO A;  4DY7 A;  3BEF A;  1TQ7 A;  1TBR J;  2A1D A;  3GIS A;  3BEI A;  3EDX A;  3LU9 A;  2PUX A;  3B9F L;  2PGQ A;  1TBQ J;  1JOU A;  3HKI A;  1AVG L;  3E6P L; 
#chains in the Genus database with same CATH topology
 2PV9 A;  2B5T A;  2ODY A;  1Z8J A;  1TB6 L;  1A0H A;  1JMO L;  3HK6 A;  4RKO A;  4DY7 A;  3BEF A;  1TQ7 A;  1TBR J;  2A1D A;  3GIS A;  3BEI A;  3EDX A;  3LU9 A;  2PUX A;  3B9F L;  2PGQ A;  1TBQ J;  1JOU A;  3HKI A;  1AVG L;  3E6P L; 
#chains in the Genus database with same CATH homology
 2PV9 A;  2B5T A;  2ODY A;  1Z8J A;  1TB6 L;  1A0H A;  1JMO L;  3HK6 A;  4RKO A;  4DY7 A;  3BEF A;  1TQ7 A;  1TBR J;  2A1D A;  3GIS A;  3BEI A;  3EDX A;  3LU9 A;  2PUX A;  3B9F L;  2PGQ A;  1TBQ J;  1JOU A;  3HKI A;  1AVG L;  3E6P L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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