1Z8JA

Crystal structure of the thrombin mutant g193p bound to ppack
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
TFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Thrombin light chain
publication title Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2005-03-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1z8jA00
1Z8JA 3HK6A 1TBRJ 2A1DA 2PGQA 2PV9A 1JMOL 2B5TA 3LU9A 3HKIA 4DY7A 3BEIA 3EDXA 3GISA 3BEFA 1TBQJ 3B9FL 1TQ7A 2ODYA 1TB6L 1A0HA 4RKOA 2PUXA 3E6PL 1JOUA 1AVGL
chains in the Genus database with same CATH superfamily
1Z8JA 3HK6A 1TBRJ 2A1DA 2PGQA 2PV9A 1JMOL 2B5TA 3LU9A 3HKIA 4DY7A 3BEIA 3EDXA 3GISA 3BEFA 1TBQJ 3B9FL 1TQ7A 2ODYA 1TB6L 1A0HA 4RKOA 2PUXA 3E6PL 1JOUA 1AVGL
chains in the Genus database with same CATH topology
1Z8JA 3HK6A 1TBRJ 2A1DA 2PGQA 2PV9A 1JMOL 2B5TA 3LU9A 3HKIA 4DY7A 3BEIA 3EDXA 3GISA 3BEFA 1TBQJ 3B9FL 1TQ7A 2ODYA 1TB6L 1A0HA 4RKOA 2PUXA 3E6PL 1JOUA 1AVGL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z8J A;  3HK6 A;  1TBR J;  2A1D A;  2PGQ A;  2PV9 A;  1JMO L;  2B5T A;  3LU9 A;  3HKI A;  4DY7 A;  3BEI A;  3EDX A;  3GIS A;  3BEF A;  1TBQ J;  3B9F L;  1TQ7 A;  2ODY A;  1TB6 L;  1A0H A;  4RKO A;  2PUX A;  3E6P L;  1JOU A;  1AVG L; 
#chains in the Genus database with same CATH topology
 1Z8J A;  3HK6 A;  1TBR J;  2A1D A;  2PGQ A;  2PV9 A;  1JMO L;  2B5T A;  3LU9 A;  3HKI A;  4DY7 A;  3BEI A;  3EDX A;  3GIS A;  3BEF A;  1TBQ J;  3B9F L;  1TQ7 A;  2ODY A;  1TB6 L;  1A0H A;  4RKO A;  2PUX A;  3E6P L;  1JOU A;  1AVG L; 
#chains in the Genus database with same CATH homology
 1Z8J A;  3HK6 A;  1TBR J;  2A1D A;  2PGQ A;  2PV9 A;  1JMO L;  2B5T A;  3LU9 A;  3HKI A;  4DY7 A;  3BEI A;  3EDX A;  3GIS A;  3BEF A;  1TBQ J;  3B9F L;  1TQ7 A;  2ODY A;  1TB6 L;  1A0H A;  4RKO A;  2PUX A;  3E6P L;  1JOU A;  1AVG L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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