1TQ7A

Crystal structure of the anticoagulant thrombin mutant w215a/e217a bound to ppack
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
44
structure length
44
Chain Sequence
YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Prothrombin
publication title The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 44
sequence length 44
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2004-06-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 1tq7A00
3B9FL 3EDXA 3HK6A 2B5TA 3HKIA 3BEIA 3LU9A 1JMOL 2PV9A 1AVGL 3E6PL 1TB6L 1JOUA 4DY7A 1TBRJ 1TBQJ 1Z8JA 2PUXA 3GISA 3BEFA 2PGQA 1TQ7A 1A0HA 4RKOA 2ODYA 2A1DA
chains in the Genus database with same CATH superfamily
3B9FL 3EDXA 3HK6A 2B5TA 3HKIA 3BEIA 3LU9A 1JMOL 2PV9A 1AVGL 3E6PL 1TB6L 1JOUA 4DY7A 1TBRJ 1TBQJ 1Z8JA 2PUXA 3GISA 3BEFA 2PGQA 1TQ7A 1A0HA 4RKOA 2ODYA 2A1DA
chains in the Genus database with same CATH topology
3B9FL 3EDXA 3HK6A 2B5TA 3HKIA 3BEIA 3LU9A 1JMOL 2PV9A 1AVGL 3E6PL 1TB6L 1JOUA 4DY7A 1TBRJ 1TBQJ 1Z8JA 2PUXA 3GISA 3BEFA 2PGQA 1TQ7A 1A0HA 4RKOA 2ODYA 2A1DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B9F L;  3EDX A;  3HK6 A;  2B5T A;  3HKI A;  3BEI A;  3LU9 A;  1JMO L;  2PV9 A;  1AVG L;  3E6P L;  1TB6 L;  1JOU A;  4DY7 A;  1TBR J;  1TBQ J;  1Z8J A;  2PUX A;  3GIS A;  3BEF A;  2PGQ A;  1TQ7 A;  1A0H A;  4RKO A;  2ODY A;  2A1D A; 
#chains in the Genus database with same CATH topology
 3B9F L;  3EDX A;  3HK6 A;  2B5T A;  3HKI A;  3BEI A;  3LU9 A;  1JMO L;  2PV9 A;  1AVG L;  3E6P L;  1TB6 L;  1JOU A;  4DY7 A;  1TBR J;  1TBQ J;  1Z8J A;  2PUX A;  3GIS A;  3BEF A;  2PGQ A;  1TQ7 A;  1A0H A;  4RKO A;  2ODY A;  2A1D A; 
#chains in the Genus database with same CATH homology
 3B9F L;  3EDX A;  3HK6 A;  2B5T A;  3HKI A;  3BEI A;  3LU9 A;  1JMO L;  2PV9 A;  1AVG L;  3E6P L;  1TB6 L;  1JOU A;  4DY7 A;  1TBR J;  1TBQ J;  1Z8J A;  2PUX A;  3GIS A;  3BEF A;  2PGQ A;  1TQ7 A;  1A0H A;  4RKO A;  2ODY A;  2A1D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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