2FMEA

Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide
Total Genus 101
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
346
structure length
320
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDLAGSENIGRINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Cell cycle
molecule keywords Kinesin-like protein KIF11
publication title Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 320
sequence length 346
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2fmeA00
1D1AA 3KINA 3ZFCA 4PJNA 3B6VA 4A5YA 1FMVA 2VVGA 2FL6A 3H4SA 2ZFMA 1V8KA 2X7EA 4GKRA 4PFOA 1VFXA 1LVKA 4A1ZA 4AS7A 4ZHIA 1BR1A 1BR2A 1II6A 2WOGA 1F9WA 4FRZA 1SDMA 2MYSA 3KENA 4A50A 2Y65A 4AP0A 3B6UA 3BFNA 3HQDA 2VB6A 5LT4A 2ZFJA 3DC4A 1BR4A 2Q2YA 3DCBA 3KARA 3PXNA 2X2RA 1I6IA 3NWNA 4PJLA 5LT1A 2ZFIA 3ZCWA 2GM1A 4LNUK 1BG2A 2XT3A 1VOMA 1VFZA 2KINA 1D1CA 2GRYA 5LT2A 1GOJA 2UYIA 5LT0A 3L9HA 2Q2ZA 4B7BA 3ZFDA 1MKJA 2Y5WA 1F9VA 1VFVA 1D1BA 3GBJA 4DBRA 4PK4A 1D0YA 4E7SA 1D0XA 4ZCAA 1X88A 1MNEA 3X2TA 2VASA 4BN2A 3T0QA 1MMDA 2FL2A 3L1CA 4ETPA 3CNZA 2HEHA 2G1QA 1G8XA 4HNAK 4ANJA 3K5EA 2V26A 3WRDA 1RY6A 5GSZA 2X51A 3U06A 2NCDA 3LREA 1MMNA 2IEHA 3K3BA 4BBGA 2X7CA 2FKYA 2ZFLA 2ZFKA 1T5CA 5HLEA 4A14A 1V8JA 4PFPA 1I5SA 2UYMA 2FMEA 1F9TA 2X7DA 3WPNA 4H1GA 5LT3A 1KK7A 1N6MA 4PJJA 4PJMA 4BXNA 1F9UA 4A51A 4DBQA 1VFWA 1CZ7A 2OWMA 4A28A 1LKXA 1MMAA 3CJOA 1MMGA 1YRSA 4E7ZA 4UBFA 1FMWA 2XAEA 2PG2A 1D0ZA 1Q0BA 4Y05A 3COBA
chains in the Genus database with same CATH superfamily
1D1AA 3KINA 3ZFCA 4PJNA 3B6VA 4A5YA 1FMVA 2VVGA 2FL6A 3H4SA 2ZFMA 1V8KA 2X7EA 4GKRA 4PFOA 1VFXA 1LVKA 4A1ZA 4AS7A 4ZHIA 1BR1A 1BR2A 1II6A 2WOGA 1F9WA 4FRZA 1SDMA 2MYSA 2O0AA 3KENA 4A50A 2Y65A 4AP0A 3B6UA 3BFNA 3HQDA 2VB6A 5LT4A 2ZFJA 3DC4A 1BR4A 2Q2YA 3DCBA 3KARA 3PXNA 2X2RA 1I6IA 3NWNA 4PJLA 5LT1A 2ZFIA 3ZCWA 2GM1A 4LNUK 1BG2A 2XT3A 1VOMA 1VFZA 2KINA 1D1CA 2GRYA 5LT2A 1GOJA 2UYIA 5LT0A 3L9HA 2Q2ZA 4B7BA 3ZFDA 1MKJA 2Y5WA 1F9VA 1VFVA 1D1BA 3GBJA 4DBRA 4GKQA 4PK4A 1D0YA 4E7SA 1D0XA 4ZCAA 1X88A 1MNEA 3X2TA 2VASA 4BN2A 3T0QA 1MMDA 2FL2A 3L1CA 4ETPA 3CNZA 2HEHA 2G1QA 1G8XA 4HNAK 4ANJA 3K5EA 2V26A 3WRDA 1RY6A 5GSZA 4ETPB 2X51A 3U06A 2NCDA 3LREA 1MMNA 2IEHA 3K3BA 4BBGA 2X7CA 2FKYA 2ZFLA 2ZFKA 1T5CA 5HLEA 4A14A 1V8JA 4PFPA 1I5SA 2UYMA 2FMEA 1F9TA 2X7DA 3WPNA 4H1GA 5LT3A 1KK7A 1N6MA 4PJJA 4PJMA 4BXNA 1F9UA 4A51A 4DBQA 1VFWA 1CZ7A 2OWMA 4A28A 1LKXA 1MMAA 3CJOA 1MMGA 1YRSA 4E7ZA 4GKPA 4UBFA 1FMWA 2XAEA 2PG2A 1D0ZA 1Q0BA 4Y05A 3COBA
chains in the Genus database with same CATH topology
1D1AA 3KINA 3ZFCA 4PJNA 3B6VA 4A5YA 1FMVA 2VVGA 2FL6A 3H4SA 2ZFMA 1V8KA 2X7EA 4GKRA 4PFOA 1VFXA 1LVKA 4A1ZA 4AS7A 4ZHIA 1BR1A 1BR2A 1II6A 2WOGA 1F9WA 4FRZA 1SDMA 2MYSA 3KENA 4A50A 2Y65A 4AP0A 3B6UA 3BFNA 3HQDA 2VB6A 5LT4A 2ZFJA 3DC4A 1BR4A 2Q2YA 3DCBA 3KARA 3PXNA 2X2RA 1I6IA 3NWNA 4PJLA 5LT1A 2ZFIA 3ZCWA 2GM1A 4LNUK 1BG2A 2XT3A 1VOMA 1VFZA 2KINA 1D1CA 2GRYA 5LT2A 1GOJA 2UYIA 5LT0A 3L9HA 2Q2ZA 4B7BA 3ZFDA 1MKJA 2Y5WA 1F9VA 1VFVA 1D1BA 3GBJA 4DBRA 4PK4A 1D0YA 4E7SA 1D0XA 4ZCAA 1X88A 1MNEA 3X2TA 2VASA 4BN2A 3T0QA 1MMDA 2FL2A 3L1CA 4ETPA 3CNZA 2HEHA 2G1QA 1G8XA 4HNAK 4ANJA 3K5EA 2V26A 3WRDA 1RY6A 5GSZA 2X51A 3U06A 2NCDA 3LREA 1MMNA 2IEHA 3K3BA 4BBGA 2X7CA 2FKYA 2ZFLA 2ZFKA 1T5CA 5HLEA 4A14A 1V8JA 4PFPA 1I5SA 2UYMA 2FMEA 1F9TA 2X7DA 3WPNA 4H1GA 5LT3A 1KK7A 1N6MA 4PJJA 4PJMA 4BXNA 1F9UA 4A51A 4DBQA 1VFWA 1CZ7A 2OWMA 4A28A 1LKXA 1MMAA 3CJOA 1MMGA 1YRSA 4E7ZA 4UBFA 1FMWA 2XAEA 2PG2A 1D0ZA 1Q0BA 4Y05A 3COBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D1A A;  3KIN A;  3ZFC A;  4PJN A;  3B6V A;  4A5Y A;  1FMV A;  2VVG A;  2FL6 A;  3H4S A;  2ZFM A;  1V8K A;  2X7E A;  4GKR A;  4PFO A;  1VFX A;  1LVK A;  4A1Z A;  4AS7 A;  4ZHI A;  1BR1 A;  1BR2 A;  1II6 A;  2WOG A;  1F9W A;  4FRZ A;  1SDM A;  2MYS A;  3KEN A;  4A50 A;  2Y65 A;  4AP0 A;  3B6U A;  3BFN A;  3HQD A;  2VB6 A;  5LT4 A;  2ZFJ A;  3DC4 A;  1BR4 A;  2Q2Y A;  3DCB A;  3KAR A;  3PXN A;  2X2R A;  1I6I A;  3NWN A;  4PJL A;  5LT1 A;  2ZFI A;  3ZCW A;  2GM1 A;  4LNU K;  1BG2 A;  2XT3 A;  1VOM A;  1VFZ A;  2KIN A;  1D1C A;  2GRY A;  5LT2 A;  1GOJ A;  2UYI A;  5LT0 A;  3L9H A;  2Q2Z A;  4B7B A;  3ZFD A;  1MKJ A;  2Y5W A;  1F9V A;  1VFV A;  1D1B A;  3GBJ A;  4DBR A;  4PK4 A;  1D0Y A;  4E7S A;  1D0X A;  4ZCA A;  1X88 A;  1MNE A;  3X2T A;  2VAS A;  4BN2 A;  3T0Q A;  1MMD A;  2FL2 A;  3L1C A;  4ETP A;  3CNZ A;  2HEH A;  2G1Q A;  1G8X A;  4HNA K;  4ANJ A;  3K5E A;  2V26 A;  3WRD A;  1RY6 A;  5GSZ A;  2X51 A;  3U06 A;  2NCD A;  3LRE A;  1MMN A;  2IEH A;  3K3B A;  4BBG A;  2X7C A;  2FKY A;  2ZFL A;  2ZFK A;  1T5C A;  5HLE A;  4A14 A;  1V8J A;  4PFP A;  1I5S A;  2UYM A;  2FME A;  1F9T A;  2X7D A;  3WPN A;  4H1G A;  5LT3 A;  1KK7 A;  1N6M A;  4PJJ A;  4PJM A;  4BXN A;  1F9U A;  4A51 A;  4DBQ A;  1VFW A;  1CZ7 A;  2OWM A;  4A28 A;  1LKX A;  1MMA A;  3CJO A;  1MMG A;  1YRS A;  4E7Z A;  4UBF A;  1FMW A;  2XAE A;  2PG2 A;  1D0Z A;  1Q0B A;  4Y05 A;  3COB A; 
#chains in the Genus database with same CATH topology
 1D1A A;  3KIN A;  3ZFC A;  4PJN A;  3B6V A;  4A5Y A;  1FMV A;  2VVG A;  2FL6 A;  3H4S A;  2ZFM A;  1V8K A;  2X7E A;  4GKR A;  4PFO A;  1VFX A;  1LVK A;  4A1Z A;  4AS7 A;  4ZHI A;  1BR1 A;  1BR2 A;  1II6 A;  2WOG A;  1F9W A;  4FRZ A;  1SDM A;  2MYS A;  2O0A A;  3KEN A;  4A50 A;  2Y65 A;  4AP0 A;  3B6U A;  3BFN A;  3HQD A;  2VB6 A;  5LT4 A;  2ZFJ A;  3DC4 A;  1BR4 A;  2Q2Y A;  3DCB A;  3KAR A;  3PXN A;  2X2R A;  1I6I A;  3NWN A;  4PJL A;  5LT1 A;  2ZFI A;  3ZCW A;  2GM1 A;  4LNU K;  1BG2 A;  2XT3 A;  1VOM A;  1VFZ A;  2KIN A;  1D1C A;  2GRY A;  5LT2 A;  1GOJ A;  2UYI A;  5LT0 A;  3L9H A;  2Q2Z A;  4B7B A;  3ZFD A;  1MKJ A;  2Y5W A;  1F9V A;  1VFV A;  1D1B A;  3GBJ A;  4DBR A;  4GKQ A;  4PK4 A;  1D0Y A;  4E7S A;  1D0X A;  4ZCA A;  1X88 A;  1MNE A;  3X2T A;  2VAS A;  4BN2 A;  3T0Q A;  1MMD A;  2FL2 A;  3L1C A;  4ETP A;  3CNZ A;  2HEH A;  2G1Q A;  1G8X A;  4HNA K;  4ANJ A;  3K5E A;  2V26 A;  3WRD A;  1RY6 A;  5GSZ A;  4ETP B;  2X51 A;  3U06 A;  2NCD A;  3LRE A;  1MMN A;  2IEH A;  3K3B A;  4BBG A;  2X7C A;  2FKY A;  2ZFL A;  2ZFK A;  1T5C A;  5HLE A;  4A14 A;  1V8J A;  4PFP A;  1I5S A;  2UYM A;  2FME A;  1F9T A;  2X7D A;  3WPN A;  4H1G A;  5LT3 A;  1KK7 A;  1N6M A;  4PJJ A;  4PJM A;  4BXN A;  1F9U A;  4A51 A;  4DBQ A;  1VFW A;  1CZ7 A;  2OWM A;  4A28 A;  1LKX A;  1MMA A;  3CJO A;  1MMG A;  1YRS A;  4E7Z A;  4GKP A;  4UBF A;  1FMW A;  2XAE A;  2PG2 A;  1D0Z A;  1Q0B A;  4Y05 A;  3COB A; 
#chains in the Genus database with same CATH homology
 1D1A A;  3KIN A;  3ZFC A;  4PJN A;  3B6V A;  4A5Y A;  1FMV A;  2VVG A;  2FL6 A;  3H4S A;  2ZFM A;  1V8K A;  2X7E A;  4GKR A;  4PFO A;  1VFX A;  1LVK A;  4A1Z A;  4AS7 A;  4ZHI A;  1BR1 A;  1BR2 A;  1II6 A;  2WOG A;  1F9W A;  4FRZ A;  1SDM A;  2MYS A;  3KEN A;  4A50 A;  2Y65 A;  4AP0 A;  3B6U A;  3BFN A;  3HQD A;  2VB6 A;  5LT4 A;  2ZFJ A;  3DC4 A;  1BR4 A;  2Q2Y A;  3DCB A;  3KAR A;  3PXN A;  2X2R A;  1I6I A;  3NWN A;  4PJL A;  5LT1 A;  2ZFI A;  3ZCW A;  2GM1 A;  4LNU K;  1BG2 A;  2XT3 A;  1VOM A;  1VFZ A;  2KIN A;  1D1C A;  2GRY A;  5LT2 A;  1GOJ A;  2UYI A;  5LT0 A;  3L9H A;  2Q2Z A;  4B7B A;  3ZFD A;  1MKJ A;  2Y5W A;  1F9V A;  1VFV A;  1D1B A;  3GBJ A;  4DBR A;  4PK4 A;  1D0Y A;  4E7S A;  1D0X A;  4ZCA A;  1X88 A;  1MNE A;  3X2T A;  2VAS A;  4BN2 A;  3T0Q A;  1MMD A;  2FL2 A;  3L1C A;  4ETP A;  3CNZ A;  2HEH A;  2G1Q A;  1G8X A;  4HNA K;  4ANJ A;  3K5E A;  2V26 A;  3WRD A;  1RY6 A;  5GSZ A;  2X51 A;  3U06 A;  2NCD A;  3LRE A;  1MMN A;  2IEH A;  3K3B A;  4BBG A;  2X7C A;  2FKY A;  2ZFL A;  2ZFK A;  1T5C A;  5HLE A;  4A14 A;  1V8J A;  4PFP A;  1I5S A;  2UYM A;  2FME A;  1F9T A;  2X7D A;  3WPN A;  4H1G A;  5LT3 A;  1KK7 A;  1N6M A;  4PJJ A;  4PJM A;  4BXN A;  1F9U A;  4A51 A;  4DBQ A;  1VFW A;  1CZ7 A;  2OWM A;  4A28 A;  1LKX A;  1MMA A;  3CJO A;  1MMG A;  1YRS A;  4E7Z A;  4UBF A;  1FMW A;  2XAE A;  2PG2 A;  1D0Z A;  1Q0B A;  4Y05 A;  3COB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...