2XAEA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((s)-2-methyl-1,1-diphenylbutylthio)propanoic acid
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
328
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
source organism Homo sapiens
total genus 104
structure length 328
sequence length 348
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2xaeA00
2MYSA 2GM1A 1N6MA 2XT3A 4PFPA 2ZFJA 5LT0A 2VVGA 3ZFDA 4PJNA 1F9TA 1T5CA 1LVKA 4A14A 4UBFA 4HNAK 3CNZA 4A5YA 4LNUK 3K5EA 1II6A 4B7BA 3T0QA 5LT2A 4ZHIA 2V26A 1D0ZA 2Y5WA 1G8XA 1V8JA 3PXNA 1LKXA 1GOJA 1BR4A 4A50A 3BFNA 2OWMA 2UYIA 1I6IA 4A51A 2FKYA 3NWNA 4BN2A 2X7EA 1KK7A 3WPNA 5LT3A 3WRDA 1FMVA 3CJOA 2NCDA 2X51A 1YRSA 2FMEA 2ZFIA 4A28A 5LT4A 1SDMA 2VB6A 3B6UA 2XAEA 4PK4A 3L9HA 5LT1A 1I5SA 3GBJA 3KINA 4H1GA 2Q2ZA 4AP0A 1D1AA 1MMDA 1MMGA 1V8KA 4AS7A 2PG2A 2GRYA 1VOMA 1X88A 2X2RA 1CZ7A 3ZCWA 1RY6A 3HQDA 3DC4A 2HEHA 3B6VA 4BXNA 4E7ZA 4BBGA 3L1CA 2IEHA 4GKRA 4PJLA 1VFWA 4Y05A 1D0YA 5HLEA 3U06A 2FL6A 1D1CA 3ZFCA 3K3BA 1F9VA 3COBA 1FMWA 1D1BA 2FL2A 4E7SA 4ZCAA 4FRZA 4PFOA 4ANJA 1MMAA 3X2TA 2WOGA 2G1QA 1MNEA 2X7DA 3H4SA 2Q2YA 2UYMA 2X7CA 3LREA 2ZFKA 3KARA 4A1ZA 5GSZA 4DBRA 1F9UA 1VFXA 2ZFLA 3KENA 4PJJA 1D0XA 4DBQA 2Y65A 2ZFMA 3DCBA 4ETPA 1MKJA 1F9WA 1VFZA 1BR2A 2VASA 1BR1A 4PJMA 1BG2A 1MMNA 1Q0BA 2KINA 1VFVA
chains in the Genus database with same CATH superfamily
2MYSA 2GM1A 1N6MA 2XT3A 4PFPA 2ZFJA 5LT0A 2VVGA 3ZFDA 4PJNA 1F9TA 1T5CA 1LVKA 4A14A 4UBFA 4HNAK 3CNZA 4A5YA 4LNUK 3K5EA 1II6A 4B7BA 3T0QA 5LT2A 4ZHIA 2V26A 1D0ZA 2Y5WA 1G8XA 1V8JA 3PXNA 1LKXA 1GOJA 1BR4A 4A50A 3BFNA 2OWMA 2UYIA 1I6IA 4A51A 2FKYA 3NWNA 4BN2A 2X7EA 1KK7A 3WPNA 5LT3A 3WRDA 1FMVA 3CJOA 2NCDA 2X51A 1YRSA 4GKPA 2FMEA 2ZFIA 4A28A 5LT4A 1SDMA 2VB6A 3B6UA 2XAEA 4PK4A 3L9HA 5LT1A 1I5SA 3GBJA 3KINA 4H1GA 2Q2ZA 4AP0A 1D1AA 1MMDA 1MMGA 1V8KA 4AS7A 2PG2A 2GRYA 1VOMA 1X88A 2X2RA 1CZ7A 3ZCWA 1RY6A 3HQDA 3DC4A 2HEHA 3B6VA 4BXNA 4E7ZA 4BBGA 3L1CA 2IEHA 4GKRA 4PJLA 1VFWA 4Y05A 1D0YA 5HLEA 3U06A 2FL6A 1D1CA 3ZFCA 3K3BA 1F9VA 3COBA 1FMWA 1D1BA 2FL2A 4E7SA 4ZCAA 4FRZA 4PFOA 4ANJA 1MMAA 3X2TA 2WOGA 2G1QA 1MNEA 2X7DA 3H4SA 2Q2YA 4ETPB 2UYMA 2X7CA 3LREA 2ZFKA 3KARA 4A1ZA 5GSZA 4DBRA 1F9UA 1VFXA 2ZFLA 3KENA 4PJJA 1D0XA 4DBQA 2Y65A 2ZFMA 3DCBA 4ETPA 1MKJA 1F9WA 1VFZA 1BR2A 2VASA 1BR1A 4PJMA 4GKQA 1BG2A 1MMNA 1Q0BA 2O0AA 2KINA 1VFVA
chains in the Genus database with same CATH topology
2MYSA 2GM1A 1N6MA 2XT3A 4PFPA 2ZFJA 5LT0A 2VVGA 3ZFDA 4PJNA 1F9TA 1T5CA 1LVKA 4A14A 4UBFA 4HNAK 3CNZA 4A5YA 4LNUK 3K5EA 1II6A 4B7BA 3T0QA 5LT2A 4ZHIA 2V26A 1D0ZA 2Y5WA 1G8XA 1V8JA 3PXNA 1LKXA 1GOJA 1BR4A 4A50A 3BFNA 2OWMA 2UYIA 1I6IA 4A51A 2FKYA 3NWNA 4BN2A 2X7EA 1KK7A 3WPNA 5LT3A 3WRDA 1FMVA 3CJOA 2NCDA 2X51A 1YRSA 2FMEA 2ZFIA 4A28A 5LT4A 1SDMA 2VB6A 3B6UA 2XAEA 4PK4A 3L9HA 5LT1A 1I5SA 3GBJA 3KINA 4H1GA 2Q2ZA 4AP0A 1D1AA 1MMDA 1MMGA 1V8KA 4AS7A 2PG2A 2GRYA 1VOMA 1X88A 2X2RA 1CZ7A 3ZCWA 1RY6A 3HQDA 3DC4A 2HEHA 3B6VA 4BXNA 4E7ZA 4BBGA 3L1CA 2IEHA 4GKRA 4PJLA 1VFWA 4Y05A 1D0YA 5HLEA 3U06A 2FL6A 1D1CA 3ZFCA 3K3BA 1F9VA 3COBA 1FMWA 1D1BA 2FL2A 4E7SA 4ZCAA 4FRZA 4PFOA 4ANJA 1MMAA 3X2TA 2WOGA 2G1QA 1MNEA 2X7DA 3H4SA 2Q2YA 2UYMA 2X7CA 3LREA 2ZFKA 3KARA 4A1ZA 5GSZA 4DBRA 1F9UA 1VFXA 2ZFLA 3KENA 4PJJA 1D0XA 4DBQA 2Y65A 2ZFMA 3DCBA 4ETPA 1MKJA 1F9WA 1VFZA 1BR2A 2VASA 1BR1A 4PJMA 1BG2A 1MMNA 1Q0BA 2KINA 1VFVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MYS A;  2GM1 A;  1N6M A;  2XT3 A;  4PFP A;  2ZFJ A;  5LT0 A;  2VVG A;  3ZFD A;  4PJN A;  1F9T A;  1T5C A;  1LVK A;  4A14 A;  4UBF A;  4HNA K;  3CNZ A;  4A5Y A;  4LNU K;  3K5E A;  1II6 A;  4B7B A;  3T0Q A;  5LT2 A;  4ZHI A;  2V26 A;  1D0Z A;  2Y5W A;  1G8X A;  1V8J A;  3PXN A;  1LKX A;  1GOJ A;  1BR4 A;  4A50 A;  3BFN A;  2OWM A;  2UYI A;  1I6I A;  4A51 A;  2FKY A;  3NWN A;  4BN2 A;  2X7E A;  1KK7 A;  3WPN A;  5LT3 A;  3WRD A;  1FMV A;  3CJO A;  2NCD A;  2X51 A;  1YRS A;  2FME A;  2ZFI A;  4A28 A;  5LT4 A;  1SDM A;  2VB6 A;  3B6U A;  2XAE A;  4PK4 A;  3L9H A;  5LT1 A;  1I5S A;  3GBJ A;  3KIN A;  4H1G A;  2Q2Z A;  4AP0 A;  1D1A A;  1MMD A;  1MMG A;  1V8K A;  4AS7 A;  2PG2 A;  2GRY A;  1VOM A;  1X88 A;  2X2R A;  1CZ7 A;  3ZCW A;  1RY6 A;  3HQD A;  3DC4 A;  2HEH A;  3B6V A;  4BXN A;  4E7Z A;  4BBG A;  3L1C A;  2IEH A;  4GKR A;  4PJL A;  1VFW A;  4Y05 A;  1D0Y A;  5HLE A;  3U06 A;  2FL6 A;  1D1C A;  3ZFC A;  3K3B A;  1F9V A;  3COB A;  1FMW A;  1D1B A;  2FL2 A;  4E7S A;  4ZCA A;  4FRZ A;  4PFO A;  4ANJ A;  1MMA A;  3X2T A;  2WOG A;  2G1Q A;  1MNE A;  2X7D A;  3H4S A;  2Q2Y A;  2UYM A;  2X7C A;  3LRE A;  2ZFK A;  3KAR A;  4A1Z A;  5GSZ A;  4DBR A;  1F9U A;  1VFX A;  2ZFL A;  3KEN A;  4PJJ A;  1D0X A;  4DBQ A;  2Y65 A;  2ZFM A;  3DCB A;  4ETP A;  1MKJ A;  1F9W A;  1VFZ A;  1BR2 A;  2VAS A;  1BR1 A;  4PJM A;  1BG2 A;  1MMN A;  1Q0B A;  2KIN A;  1VFV A; 
#chains in the Genus database with same CATH topology
 2MYS A;  2GM1 A;  1N6M A;  2XT3 A;  4PFP A;  2ZFJ A;  5LT0 A;  2VVG A;  3ZFD A;  4PJN A;  1F9T A;  1T5C A;  1LVK A;  4A14 A;  4UBF A;  4HNA K;  3CNZ A;  4A5Y A;  4LNU K;  3K5E A;  1II6 A;  4B7B A;  3T0Q A;  5LT2 A;  4ZHI A;  2V26 A;  1D0Z A;  2Y5W A;  1G8X A;  1V8J A;  3PXN A;  1LKX A;  1GOJ A;  1BR4 A;  4A50 A;  3BFN A;  2OWM A;  2UYI A;  1I6I A;  4A51 A;  2FKY A;  3NWN A;  4BN2 A;  2X7E A;  1KK7 A;  3WPN A;  5LT3 A;  3WRD A;  1FMV A;  3CJO A;  2NCD A;  2X51 A;  1YRS A;  4GKP A;  2FME A;  2ZFI A;  4A28 A;  5LT4 A;  1SDM A;  2VB6 A;  3B6U A;  2XAE A;  4PK4 A;  3L9H A;  5LT1 A;  1I5S A;  3GBJ A;  3KIN A;  4H1G A;  2Q2Z A;  4AP0 A;  1D1A A;  1MMD A;  1MMG A;  1V8K A;  4AS7 A;  2PG2 A;  2GRY A;  1VOM A;  1X88 A;  2X2R A;  1CZ7 A;  3ZCW A;  1RY6 A;  3HQD A;  3DC4 A;  2HEH A;  3B6V A;  4BXN A;  4E7Z A;  4BBG A;  3L1C A;  2IEH A;  4GKR A;  4PJL A;  1VFW A;  4Y05 A;  1D0Y A;  5HLE A;  3U06 A;  2FL6 A;  1D1C A;  3ZFC A;  3K3B A;  1F9V A;  3COB A;  1FMW A;  1D1B A;  2FL2 A;  4E7S A;  4ZCA A;  4FRZ A;  4PFO A;  4ANJ A;  1MMA A;  3X2T A;  2WOG A;  2G1Q A;  1MNE A;  2X7D A;  3H4S A;  2Q2Y A;  4ETP B;  2UYM A;  2X7C A;  3LRE A;  2ZFK A;  3KAR A;  4A1Z A;  5GSZ A;  4DBR A;  1F9U A;  1VFX A;  2ZFL A;  3KEN A;  4PJJ A;  1D0X A;  4DBQ A;  2Y65 A;  2ZFM A;  3DCB A;  4ETP A;  1MKJ A;  1F9W A;  1VFZ A;  1BR2 A;  2VAS A;  1BR1 A;  4PJM A;  4GKQ A;  1BG2 A;  1MMN A;  1Q0B A;  2O0A A;  2KIN A;  1VFV A; 
#chains in the Genus database with same CATH homology
 2MYS A;  2GM1 A;  1N6M A;  2XT3 A;  4PFP A;  2ZFJ A;  5LT0 A;  2VVG A;  3ZFD A;  4PJN A;  1F9T A;  1T5C A;  1LVK A;  4A14 A;  4UBF A;  4HNA K;  3CNZ A;  4A5Y A;  4LNU K;  3K5E A;  1II6 A;  4B7B A;  3T0Q A;  5LT2 A;  4ZHI A;  2V26 A;  1D0Z A;  2Y5W A;  1G8X A;  1V8J A;  3PXN A;  1LKX A;  1GOJ A;  1BR4 A;  4A50 A;  3BFN A;  2OWM A;  2UYI A;  1I6I A;  4A51 A;  2FKY A;  3NWN A;  4BN2 A;  2X7E A;  1KK7 A;  3WPN A;  5LT3 A;  3WRD A;  1FMV A;  3CJO A;  2NCD A;  2X51 A;  1YRS A;  2FME A;  2ZFI A;  4A28 A;  5LT4 A;  1SDM A;  2VB6 A;  3B6U A;  2XAE A;  4PK4 A;  3L9H A;  5LT1 A;  1I5S A;  3GBJ A;  3KIN A;  4H1G A;  2Q2Z A;  4AP0 A;  1D1A A;  1MMD A;  1MMG A;  1V8K A;  4AS7 A;  2PG2 A;  2GRY A;  1VOM A;  1X88 A;  2X2R A;  1CZ7 A;  3ZCW A;  1RY6 A;  3HQD A;  3DC4 A;  2HEH A;  3B6V A;  4BXN A;  4E7Z A;  4BBG A;  3L1C A;  2IEH A;  4GKR A;  4PJL A;  1VFW A;  4Y05 A;  1D0Y A;  5HLE A;  3U06 A;  2FL6 A;  1D1C A;  3ZFC A;  3K3B A;  1F9V A;  3COB A;  1FMW A;  1D1B A;  2FL2 A;  4E7S A;  4ZCA A;  4FRZ A;  4PFO A;  4ANJ A;  1MMA A;  3X2T A;  2WOG A;  2G1Q A;  1MNE A;  2X7D A;  3H4S A;  2Q2Y A;  2UYM A;  2X7C A;  3LRE A;  2ZFK A;  3KAR A;  4A1Z A;  5GSZ A;  4DBR A;  1F9U A;  1VFX A;  2ZFL A;  3KEN A;  4PJJ A;  1D0X A;  4DBQ A;  2Y65 A;  2ZFM A;  3DCB A;  4ETP A;  1MKJ A;  1F9W A;  1VFZ A;  1BR2 A;  2VAS A;  1BR1 A;  4PJM A;  1BG2 A;  1MMN A;  1Q0B A;  2KIN A;  1VFV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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