3K3BA

Co-crystal structure of the human kinesin eg5 with a novel tetrahydro-beta-carboline
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
349
structure length
335
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Motor protein
molecule keywords Kinesin-like protein KIF11
publication title The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
pubmed doi rcsb
source organism Homo sapiens
total genus 103
structure length 335
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3k3bA00
4PFPA 4ZCAA 2XT3A 4FRZA 1D1BA 3DC4A 1MMNA 3CJOA 1I5SA 2X7DA 4LNUK 1VFZA 1D0ZA 2Q2ZA 1D1CA 5HLEA 3HQDA 2FKYA 2ZFKA 1BR4A 1VFVA 4PFOA 1D0YA 4GKRA 4H1GA 3KINA 2X51A 3B6UA 2IEHA 1LKXA 2ZFIA 1I6IA 4A1ZA 1D0XA 2FL6A 2HEHA 2PG2A 1D1AA 2X7CA 3KENA 3DCBA 3ZFDA 2UYIA 5LT0A 4A50A 2ZFLA 2VASA 1BG2A 5LT2A 5LT3A 1VFXA 2VVGA 2KINA 1V8KA 3K5EA 4HNAK 2FL2A 2MYSA 2Y5WA 4BN2A 1F9WA 4UBFA 2UYMA 4ZHIA 1RY6A 4Y05A 3GBJA 5GSZA 2WOGA 4ANJA 4AP0A 1G8XA 4DBQA 3L9HA 1YRSA 2ZFJA 4DBRA 3X2TA 3ZCWA 1T5CA 4A51A 2GM1A 2OWMA 1MNEA 3L1CA 2GRYA 1V8JA 4PJNA 3H4SA 4PJMA 3NWNA 2ZFMA 1FMVA 1VOMA 2Y65A 2G1QA 2X7EA 3CNZA 3PXNA 3COBA 3K3BA 3ZFCA 2V26A 1FMWA 4E7SA 2NCDA 4BXNA 1Q0BA 1GOJA 2XAEA 1LVKA 2VB6A 4B7BA 4BBGA 4A28A 1F9UA 1VFWA 1KK7A 1MMGA 3U06A 1X88A 1N6MA 4ETPA 4A5YA 4PJJA 4PK4A 3LREA 2Q2YA 3WRDA 1F9TA 4PJLA 3KARA 1MMDA 3T0QA 5LT4A 1II6A 1MKJA 2X2RA 2FMEA 5LT1A 3WPNA 1BR2A 1MMAA 4E7ZA 3B6VA 1F9VA 4A14A 3BFNA 1CZ7A 1SDMA 1BR1A 4AS7A
chains in the Genus database with same CATH superfamily
4PFPA 4ZCAA 2XT3A 4FRZA 1D1BA 3DC4A 1MMNA 3CJOA 1I5SA 2X7DA 4LNUK 1VFZA 1D0ZA 2Q2ZA 1D1CA 5HLEA 3HQDA 2FKYA 2ZFKA 1BR4A 1VFVA 4PFOA 1D0YA 4GKRA 4H1GA 3KINA 2X51A 3B6UA 2IEHA 1LKXA 2ZFIA 1I6IA 4A1ZA 1D0XA 2FL6A 2HEHA 2PG2A 1D1AA 2X7CA 3KENA 3DCBA 3ZFDA 2UYIA 5LT0A 4A50A 2ZFLA 2VASA 4GKPA 1BG2A 5LT2A 4ETPB 5LT3A 1VFXA 2VVGA 2KINA 1V8KA 3K5EA 4HNAK 2FL2A 2MYSA 2Y5WA 4BN2A 1F9WA 4UBFA 2UYMA 4ZHIA 1RY6A 4Y05A 3GBJA 5GSZA 2WOGA 4ANJA 4AP0A 1G8XA 4DBQA 3L9HA 1YRSA 2ZFJA 4DBRA 3X2TA 3ZCWA 1T5CA 4A51A 2GM1A 2OWMA 1MNEA 3L1CA 2GRYA 1V8JA 4PJNA 3H4SA 4PJMA 3NWNA 2ZFMA 1FMVA 1VOMA 2G1QA 2O0AA 2X7EA 2Y65A 3CNZA 3PXNA 4GKQA 3COBA 3K3BA 3ZFCA 2V26A 1FMWA 4E7SA 2NCDA 4BXNA 1Q0BA 1GOJA 2XAEA 1LVKA 2VB6A 4B7BA 4BBGA 4A28A 1F9UA 1VFWA 1KK7A 1MMGA 3U06A 1X88A 1N6MA 4ETPA 4A5YA 4PJJA 4PK4A 3LREA 2Q2YA 3WRDA 1F9TA 4PJLA 3KARA 1MMDA 3T0QA 5LT4A 1II6A 1MKJA 2X2RA 2FMEA 5LT1A 3WPNA 1BR2A 1MMAA 4E7ZA 3B6VA 1F9VA 4A14A 3BFNA 1CZ7A 1SDMA 1BR1A 4AS7A
chains in the Genus database with same CATH topology
4PFPA 4ZCAA 2XT3A 4FRZA 1D1BA 3DC4A 1MMNA 3CJOA 1I5SA 2X7DA 4LNUK 1VFZA 1D0ZA 2Q2ZA 1D1CA 5HLEA 3HQDA 2FKYA 2ZFKA 1BR4A 1VFVA 4PFOA 1D0YA 4GKRA 4H1GA 3KINA 2X51A 3B6UA 2IEHA 1LKXA 2ZFIA 1I6IA 4A1ZA 1D0XA 2FL6A 2HEHA 2PG2A 1D1AA 2X7CA 3KENA 3DCBA 3ZFDA 2UYIA 5LT0A 4A50A 2ZFLA 2VASA 1BG2A 5LT2A 5LT3A 1VFXA 2VVGA 2KINA 1V8KA 3K5EA 4HNAK 2FL2A 2MYSA 2Y5WA 4BN2A 1F9WA 4UBFA 2UYMA 4ZHIA 1RY6A 4Y05A 3GBJA 5GSZA 2WOGA 4ANJA 4AP0A 1G8XA 4DBQA 3L9HA 1YRSA 2ZFJA 4DBRA 3X2TA 3ZCWA 1T5CA 4A51A 2GM1A 2OWMA 1MNEA 3L1CA 2GRYA 1V8JA 4PJNA 3H4SA 4PJMA 3NWNA 2ZFMA 1FMVA 1VOMA 2Y65A 2G1QA 2X7EA 3CNZA 3PXNA 3COBA 3K3BA 3ZFCA 2V26A 1FMWA 4E7SA 2NCDA 4BXNA 1Q0BA 1GOJA 2XAEA 1LVKA 2VB6A 4B7BA 4BBGA 4A28A 1F9UA 1VFWA 1KK7A 1MMGA 3U06A 1X88A 1N6MA 4ETPA 4A5YA 4PJJA 4PK4A 3LREA 2Q2YA 3WRDA 1F9TA 4PJLA 3KARA 1MMDA 3T0QA 5LT4A 1II6A 1MKJA 2X2RA 2FMEA 5LT1A 3WPNA 1BR2A 1MMAA 4E7ZA 3B6VA 1F9VA 4A14A 3BFNA 1CZ7A 1SDMA 1BR1A 4AS7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PFP A;  4ZCA A;  2XT3 A;  4FRZ A;  1D1B A;  3DC4 A;  1MMN A;  3CJO A;  1I5S A;  2X7D A;  4LNU K;  1VFZ A;  1D0Z A;  2Q2Z A;  1D1C A;  5HLE A;  3HQD A;  2FKY A;  2ZFK A;  1BR4 A;  1VFV A;  4PFO A;  1D0Y A;  4GKR A;  4H1G A;  3KIN A;  2X51 A;  3B6U A;  2IEH A;  1LKX A;  2ZFI A;  1I6I A;  4A1Z A;  1D0X A;  2FL6 A;  2HEH A;  2PG2 A;  1D1A A;  2X7C A;  3KEN A;  3DCB A;  3ZFD A;  2UYI A;  5LT0 A;  4A50 A;  2ZFL A;  2VAS A;  1BG2 A;  5LT2 A;  5LT3 A;  1VFX A;  2VVG A;  2KIN A;  1V8K A;  3K5E A;  4HNA K;  2FL2 A;  2MYS A;  2Y5W A;  4BN2 A;  1F9W A;  4UBF A;  2UYM A;  4ZHI A;  1RY6 A;  4Y05 A;  3GBJ A;  5GSZ A;  2WOG A;  4ANJ A;  4AP0 A;  1G8X A;  4DBQ A;  3L9H A;  1YRS A;  2ZFJ A;  4DBR A;  3X2T A;  3ZCW A;  1T5C A;  4A51 A;  2GM1 A;  2OWM A;  1MNE A;  3L1C A;  2GRY A;  1V8J A;  4PJN A;  3H4S A;  4PJM A;  3NWN A;  2ZFM A;  1FMV A;  1VOM A;  2Y65 A;  2G1Q A;  2X7E A;  3CNZ A;  3PXN A;  3COB A;  3K3B A;  3ZFC A;  2V26 A;  1FMW A;  4E7S A;  2NCD A;  4BXN A;  1Q0B A;  1GOJ A;  2XAE A;  1LVK A;  2VB6 A;  4B7B A;  4BBG A;  4A28 A;  1F9U A;  1VFW A;  1KK7 A;  1MMG A;  3U06 A;  1X88 A;  1N6M A;  4ETP A;  4A5Y A;  4PJJ A;  4PK4 A;  3LRE A;  2Q2Y A;  3WRD A;  1F9T A;  4PJL A;  3KAR A;  1MMD A;  3T0Q A;  5LT4 A;  1II6 A;  1MKJ A;  2X2R A;  2FME A;  5LT1 A;  3WPN A;  1BR2 A;  1MMA A;  4E7Z A;  3B6V A;  1F9V A;  4A14 A;  3BFN A;  1CZ7 A;  1SDM A;  1BR1 A;  4AS7 A; 
#chains in the Genus database with same CATH topology
 4PFP A;  4ZCA A;  2XT3 A;  4FRZ A;  1D1B A;  3DC4 A;  1MMN A;  3CJO A;  1I5S A;  2X7D A;  4LNU K;  1VFZ A;  1D0Z A;  2Q2Z A;  1D1C A;  5HLE A;  3HQD A;  2FKY A;  2ZFK A;  1BR4 A;  1VFV A;  4PFO A;  1D0Y A;  4GKR A;  4H1G A;  3KIN A;  2X51 A;  3B6U A;  2IEH A;  1LKX A;  2ZFI A;  1I6I A;  4A1Z A;  1D0X A;  2FL6 A;  2HEH A;  2PG2 A;  1D1A A;  2X7C A;  3KEN A;  3DCB A;  3ZFD A;  2UYI A;  5LT0 A;  4A50 A;  2ZFL A;  2VAS A;  4GKP A;  1BG2 A;  5LT2 A;  4ETP B;  5LT3 A;  1VFX A;  2VVG A;  2KIN A;  1V8K A;  3K5E A;  4HNA K;  2FL2 A;  2MYS A;  2Y5W A;  4BN2 A;  1F9W A;  4UBF A;  2UYM A;  4ZHI A;  1RY6 A;  4Y05 A;  3GBJ A;  5GSZ A;  2WOG A;  4ANJ A;  4AP0 A;  1G8X A;  4DBQ A;  3L9H A;  1YRS A;  2ZFJ A;  4DBR A;  3X2T A;  3ZCW A;  1T5C A;  4A51 A;  2GM1 A;  2OWM A;  1MNE A;  3L1C A;  2GRY A;  1V8J A;  4PJN A;  3H4S A;  4PJM A;  3NWN A;  2ZFM A;  1FMV A;  1VOM A;  2G1Q A;  2O0A A;  2X7E A;  2Y65 A;  3CNZ A;  3PXN A;  4GKQ A;  3COB A;  3K3B A;  3ZFC A;  2V26 A;  1FMW A;  4E7S A;  2NCD A;  4BXN A;  1Q0B A;  1GOJ A;  2XAE A;  1LVK A;  2VB6 A;  4B7B A;  4BBG A;  4A28 A;  1F9U A;  1VFW A;  1KK7 A;  1MMG A;  3U06 A;  1X88 A;  1N6M A;  4ETP A;  4A5Y A;  4PJJ A;  4PK4 A;  3LRE A;  2Q2Y A;  3WRD A;  1F9T A;  4PJL A;  3KAR A;  1MMD A;  3T0Q A;  5LT4 A;  1II6 A;  1MKJ A;  2X2R A;  2FME A;  5LT1 A;  3WPN A;  1BR2 A;  1MMA A;  4E7Z A;  3B6V A;  1F9V A;  4A14 A;  3BFN A;  1CZ7 A;  1SDM A;  1BR1 A;  4AS7 A; 
#chains in the Genus database with same CATH homology
 4PFP A;  4ZCA A;  2XT3 A;  4FRZ A;  1D1B A;  3DC4 A;  1MMN A;  3CJO A;  1I5S A;  2X7D A;  4LNU K;  1VFZ A;  1D0Z A;  2Q2Z A;  1D1C A;  5HLE A;  3HQD A;  2FKY A;  2ZFK A;  1BR4 A;  1VFV A;  4PFO A;  1D0Y A;  4GKR A;  4H1G A;  3KIN A;  2X51 A;  3B6U A;  2IEH A;  1LKX A;  2ZFI A;  1I6I A;  4A1Z A;  1D0X A;  2FL6 A;  2HEH A;  2PG2 A;  1D1A A;  2X7C A;  3KEN A;  3DCB A;  3ZFD A;  2UYI A;  5LT0 A;  4A50 A;  2ZFL A;  2VAS A;  1BG2 A;  5LT2 A;  5LT3 A;  1VFX A;  2VVG A;  2KIN A;  1V8K A;  3K5E A;  4HNA K;  2FL2 A;  2MYS A;  2Y5W A;  4BN2 A;  1F9W A;  4UBF A;  2UYM A;  4ZHI A;  1RY6 A;  4Y05 A;  3GBJ A;  5GSZ A;  2WOG A;  4ANJ A;  4AP0 A;  1G8X A;  4DBQ A;  3L9H A;  1YRS A;  2ZFJ A;  4DBR A;  3X2T A;  3ZCW A;  1T5C A;  4A51 A;  2GM1 A;  2OWM A;  1MNE A;  3L1C A;  2GRY A;  1V8J A;  4PJN A;  3H4S A;  4PJM A;  3NWN A;  2ZFM A;  1FMV A;  1VOM A;  2Y65 A;  2G1Q A;  2X7E A;  3CNZ A;  3PXN A;  3COB A;  3K3B A;  3ZFC A;  2V26 A;  1FMW A;  4E7S A;  2NCD A;  4BXN A;  1Q0B A;  1GOJ A;  2XAE A;  1LVK A;  2VB6 A;  4B7B A;  4BBG A;  4A28 A;  1F9U A;  1VFW A;  1KK7 A;  1MMG A;  3U06 A;  1X88 A;  1N6M A;  4ETP A;  4A5Y A;  4PJJ A;  4PK4 A;  3LRE A;  2Q2Y A;  3WRD A;  1F9T A;  4PJL A;  3KAR A;  1MMD A;  3T0Q A;  5LT4 A;  1II6 A;  1MKJ A;  2X2R A;  2FME A;  5LT1 A;  3WPN A;  1BR2 A;  1MMA A;  4E7Z A;  3B6V A;  1F9V A;  4A14 A;  3BFN A;  1CZ7 A;  1SDM A;  1BR1 A;  4AS7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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