2X7CA

Crystal structure of human kinesin eg5 in complex with (s)-enastron
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
total genus 104
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7cA00
3B6UA 3KARA 2XT3A 3LREA 3CNZA 3COBA 4H1GA 3L9HA 4PFOA 1CZ7A 1MMGA 3NWNA 1MKJA 1GOJA 4PJMA 4ZHIA 1D0YA 4PJNA 4E7SA 1T5CA 1MMNA 3H4SA 2WOGA 4Y05A 2ZFLA 2XAEA 1BG2A 2KINA 2OWMA 2Y5WA 3L1CA 3HQDA 3ZCWA 2ZFIA 2PG2A 1V8KA 5HLEA 1F9VA 4AS7A 2X51A 4BXNA 3GBJA 5LT1A 1LKXA 3WRDA 2GM1A 1BR2A 4FRZA 1D1CA 2FL2A 2UYMA 2VVGA 2GRYA 1MNEA 4PK4A 3DCBA 4ANJA 3T0QA 4A50A 2UYIA 1I5SA 5LT3A 3KENA 1G8XA 1KK7A 4HNAK 4BN2A 4ETPA 1F9WA 3X2TA 1FMVA 1RY6A 1BR4A 1F9TA 3KINA 4DBRA 4AP0A 2ZFMA 1MMDA 5GSZA 1VOMA 1VFVA 1N6MA 5LT2A 2VB6A 4A14A 4BBGA 3ZFCA 3CJOA 1SDMA 1I6IA 1VFZA 2HEHA 2X2RA 2Q2ZA 3B6VA 3K3BA 2VASA 4LNUK 2IEHA 3WPNA 1VFWA 4GKRA 3PXNA 2Y65A 2FKYA 4A51A 3ZFDA 4E7ZA 1F9UA 1D0ZA 2FL6A 1V8JA 1Q0BA 3U06A 2X7EA 4UBFA 1X88A 1II6A 2ZFJA 2FMEA 1VFXA 1D1AA 4ZCAA 5LT0A 3DC4A 1D0XA 1YRSA 3BFNA 3K5EA 4PFPA 1MMAA 2NCDA 2V26A 5LT4A 2X7DA 4B7BA 1LVKA 2Q2YA 4A1ZA 2G1QA 2MYSA 4DBQA 1D1BA 4A28A 2ZFKA 1BR1A 1FMWA 4A5YA 2X7CA 4PJJA 4PJLA
chains in the Genus database with same CATH superfamily
4ETPB 3B6UA 3KARA 2XT3A 3LREA 3CNZA 3COBA 4H1GA 3L9HA 4PFOA 1CZ7A 1MMGA 3NWNA 4GKPA 1MKJA 1GOJA 4PJMA 4ZHIA 1D0YA 4PJNA 4E7SA 1T5CA 1MMNA 3H4SA 2WOGA 4Y05A 2ZFLA 2XAEA 1BG2A 2KINA 2OWMA 2Y5WA 3L1CA 3HQDA 3ZCWA 2ZFIA 2PG2A 4GKQA 1V8KA 5HLEA 1F9VA 4AS7A 2X51A 4BXNA 3GBJA 5LT1A 1LKXA 3WRDA 2GM1A 1BR2A 4FRZA 1D1CA 2FL2A 2UYMA 2VVGA 2GRYA 1MNEA 4PK4A 3DCBA 4ANJA 3T0QA 4A50A 2UYIA 1I5SA 5LT3A 3KENA 1G8XA 1KK7A 4HNAK 4BN2A 4ETPA 1F9WA 3X2TA 1FMVA 1RY6A 1BR4A 1F9TA 3KINA 4DBRA 4AP0A 2ZFMA 1MMDA 5GSZA 1VOMA 1VFVA 1N6MA 5LT2A 2VB6A 4A14A 4BBGA 3ZFCA 3CJOA 1SDMA 1I6IA 1VFZA 2HEHA 2X2RA 2Q2ZA 3B6VA 3K3BA 2VASA 4LNUK 2IEHA 3WPNA 1VFWA 4GKRA 3PXNA 2Y65A 2FKYA 4A51A 3ZFDA 4E7ZA 1F9UA 1D0ZA 2FL6A 1V8JA 1Q0BA 3U06A 2X7EA 4UBFA 1X88A 1II6A 2ZFJA 2FMEA 1VFXA 1D1AA 4ZCAA 5LT0A 3DC4A 1D0XA 1YRSA 3BFNA 3K5EA 4PFPA 1MMAA 2NCDA 2V26A 5LT4A 2X7DA 2O0AA 4B7BA 1LVKA 2Q2YA 4A1ZA 2G1QA 2MYSA 4DBQA 1D1BA 4A28A 2ZFKA 1BR1A 1FMWA 4A5YA 2X7CA 4PJJA 4PJLA
chains in the Genus database with same CATH topology
3B6UA 3KARA 2XT3A 3LREA 3CNZA 3COBA 4H1GA 3L9HA 4PFOA 1CZ7A 1MMGA 3NWNA 1MKJA 1GOJA 4PJMA 4ZHIA 1D0YA 4PJNA 4E7SA 1T5CA 1MMNA 3H4SA 2WOGA 4Y05A 2ZFLA 2XAEA 1BG2A 2KINA 2OWMA 2Y5WA 3L1CA 3HQDA 3ZCWA 2ZFIA 2PG2A 1V8KA 5HLEA 1F9VA 4AS7A 2X51A 4BXNA 3GBJA 5LT1A 1LKXA 3WRDA 2GM1A 1BR2A 4FRZA 1D1CA 2FL2A 2UYMA 2VVGA 2GRYA 1MNEA 4PK4A 3DCBA 4ANJA 3T0QA 4A50A 2UYIA 1I5SA 5LT3A 3KENA 1G8XA 1KK7A 4HNAK 4BN2A 4ETPA 1F9WA 3X2TA 1FMVA 1RY6A 1BR4A 1F9TA 3KINA 4DBRA 4AP0A 2ZFMA 1MMDA 5GSZA 1VOMA 1VFVA 1N6MA 5LT2A 2VB6A 4A14A 4BBGA 3ZFCA 3CJOA 1SDMA 1I6IA 1VFZA 2HEHA 2X2RA 2Q2ZA 3B6VA 3K3BA 2VASA 4LNUK 2IEHA 3WPNA 1VFWA 4GKRA 3PXNA 2Y65A 2FKYA 4A51A 3ZFDA 4E7ZA 1F9UA 1D0ZA 2FL6A 1V8JA 1Q0BA 3U06A 2X7EA 4UBFA 1X88A 1II6A 2ZFJA 2FMEA 1VFXA 1D1AA 4ZCAA 5LT0A 3DC4A 1D0XA 1YRSA 3BFNA 3K5EA 4PFPA 1MMAA 2NCDA 2V26A 5LT4A 2X7DA 4B7BA 1LVKA 2Q2YA 4A1ZA 2G1QA 2MYSA 4DBQA 1D1BA 4A28A 2ZFKA 1BR1A 1FMWA 4A5YA 2X7CA 4PJJA 4PJLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B6U A;  3KAR A;  2XT3 A;  3LRE A;  3CNZ A;  3COB A;  4H1G A;  3L9H A;  4PFO A;  1CZ7 A;  1MMG A;  3NWN A;  1MKJ A;  1GOJ A;  4PJM A;  4ZHI A;  1D0Y A;  4PJN A;  4E7S A;  1T5C A;  1MMN A;  3H4S A;  2WOG A;  4Y05 A;  2ZFL A;  2XAE A;  1BG2 A;  2KIN A;  2OWM A;  2Y5W A;  3L1C A;  3HQD A;  3ZCW A;  2ZFI A;  2PG2 A;  1V8K A;  5HLE A;  1F9V A;  4AS7 A;  2X51 A;  4BXN A;  3GBJ A;  5LT1 A;  1LKX A;  3WRD A;  2GM1 A;  1BR2 A;  4FRZ A;  1D1C A;  2FL2 A;  2UYM A;  2VVG A;  2GRY A;  1MNE A;  4PK4 A;  3DCB A;  4ANJ A;  3T0Q A;  4A50 A;  2UYI A;  1I5S A;  5LT3 A;  3KEN A;  1G8X A;  1KK7 A;  4HNA K;  4BN2 A;  4ETP A;  1F9W A;  3X2T A;  1FMV A;  1RY6 A;  1BR4 A;  1F9T A;  3KIN A;  4DBR A;  4AP0 A;  2ZFM A;  1MMD A;  5GSZ A;  1VOM A;  1VFV A;  1N6M A;  5LT2 A;  2VB6 A;  4A14 A;  4BBG A;  3ZFC A;  3CJO A;  1SDM A;  1I6I A;  1VFZ A;  2HEH A;  2X2R A;  2Q2Z A;  3B6V A;  3K3B A;  2VAS A;  4LNU K;  2IEH A;  3WPN A;  1VFW A;  4GKR A;  3PXN A;  2Y65 A;  2FKY A;  4A51 A;  3ZFD A;  4E7Z A;  1F9U A;  1D0Z A;  2FL6 A;  1V8J A;  1Q0B A;  3U06 A;  2X7E A;  4UBF A;  1X88 A;  1II6 A;  2ZFJ A;  2FME A;  1VFX A;  1D1A A;  4ZCA A;  5LT0 A;  3DC4 A;  1D0X A;  1YRS A;  3BFN A;  3K5E A;  4PFP A;  1MMA A;  2NCD A;  2V26 A;  5LT4 A;  2X7D A;  4B7B A;  1LVK A;  2Q2Y A;  4A1Z A;  2G1Q A;  2MYS A;  4DBQ A;  1D1B A;  4A28 A;  2ZFK A;  1BR1 A;  1FMW A;  4A5Y A;  2X7C A;  4PJJ A;  4PJL A; 
#chains in the Genus database with same CATH topology
 4ETP B;  3B6U A;  3KAR A;  2XT3 A;  3LRE A;  3CNZ A;  3COB A;  4H1G A;  3L9H A;  4PFO A;  1CZ7 A;  1MMG A;  3NWN A;  4GKP A;  1MKJ A;  1GOJ A;  4PJM A;  4ZHI A;  1D0Y A;  4PJN A;  4E7S A;  1T5C A;  1MMN A;  3H4S A;  2WOG A;  4Y05 A;  2ZFL A;  2XAE A;  1BG2 A;  2KIN A;  2OWM A;  2Y5W A;  3L1C A;  3HQD A;  3ZCW A;  2ZFI A;  2PG2 A;  4GKQ A;  1V8K A;  5HLE A;  1F9V A;  4AS7 A;  2X51 A;  4BXN A;  3GBJ A;  5LT1 A;  1LKX A;  3WRD A;  2GM1 A;  1BR2 A;  4FRZ A;  1D1C A;  2FL2 A;  2UYM A;  2VVG A;  2GRY A;  1MNE A;  4PK4 A;  3DCB A;  4ANJ A;  3T0Q A;  4A50 A;  2UYI A;  1I5S A;  5LT3 A;  3KEN A;  1G8X A;  1KK7 A;  4HNA K;  4BN2 A;  4ETP A;  1F9W A;  3X2T A;  1FMV A;  1RY6 A;  1BR4 A;  1F9T A;  3KIN A;  4DBR A;  4AP0 A;  2ZFM A;  1MMD A;  5GSZ A;  1VOM A;  1VFV A;  1N6M A;  5LT2 A;  2VB6 A;  4A14 A;  4BBG A;  3ZFC A;  3CJO A;  1SDM A;  1I6I A;  1VFZ A;  2HEH A;  2X2R A;  2Q2Z A;  3B6V A;  3K3B A;  2VAS A;  4LNU K;  2IEH A;  3WPN A;  1VFW A;  4GKR A;  3PXN A;  2Y65 A;  2FKY A;  4A51 A;  3ZFD A;  4E7Z A;  1F9U A;  1D0Z A;  2FL6 A;  1V8J A;  1Q0B A;  3U06 A;  2X7E A;  4UBF A;  1X88 A;  1II6 A;  2ZFJ A;  2FME A;  1VFX A;  1D1A A;  4ZCA A;  5LT0 A;  3DC4 A;  1D0X A;  1YRS A;  3BFN A;  3K5E A;  4PFP A;  1MMA A;  2NCD A;  2V26 A;  5LT4 A;  2X7D A;  2O0A A;  4B7B A;  1LVK A;  2Q2Y A;  4A1Z A;  2G1Q A;  2MYS A;  4DBQ A;  1D1B A;  4A28 A;  2ZFK A;  1BR1 A;  1FMW A;  4A5Y A;  2X7C A;  4PJJ A;  4PJL A; 
#chains in the Genus database with same CATH homology
 3B6U A;  3KAR A;  2XT3 A;  3LRE A;  3CNZ A;  3COB A;  4H1G A;  3L9H A;  4PFO A;  1CZ7 A;  1MMG A;  3NWN A;  1MKJ A;  1GOJ A;  4PJM A;  4ZHI A;  1D0Y A;  4PJN A;  4E7S A;  1T5C A;  1MMN A;  3H4S A;  2WOG A;  4Y05 A;  2ZFL A;  2XAE A;  1BG2 A;  2KIN A;  2OWM A;  2Y5W A;  3L1C A;  3HQD A;  3ZCW A;  2ZFI A;  2PG2 A;  1V8K A;  5HLE A;  1F9V A;  4AS7 A;  2X51 A;  4BXN A;  3GBJ A;  5LT1 A;  1LKX A;  3WRD A;  2GM1 A;  1BR2 A;  4FRZ A;  1D1C A;  2FL2 A;  2UYM A;  2VVG A;  2GRY A;  1MNE A;  4PK4 A;  3DCB A;  4ANJ A;  3T0Q A;  4A50 A;  2UYI A;  1I5S A;  5LT3 A;  3KEN A;  1G8X A;  1KK7 A;  4HNA K;  4BN2 A;  4ETP A;  1F9W A;  3X2T A;  1FMV A;  1RY6 A;  1BR4 A;  1F9T A;  3KIN A;  4DBR A;  4AP0 A;  2ZFM A;  1MMD A;  5GSZ A;  1VOM A;  1VFV A;  1N6M A;  5LT2 A;  2VB6 A;  4A14 A;  4BBG A;  3ZFC A;  3CJO A;  1SDM A;  1I6I A;  1VFZ A;  2HEH A;  2X2R A;  2Q2Z A;  3B6V A;  3K3B A;  2VAS A;  4LNU K;  2IEH A;  3WPN A;  1VFW A;  4GKR A;  3PXN A;  2Y65 A;  2FKY A;  4A51 A;  3ZFD A;  4E7Z A;  1F9U A;  1D0Z A;  2FL6 A;  1V8J A;  1Q0B A;  3U06 A;  2X7E A;  4UBF A;  1X88 A;  1II6 A;  2ZFJ A;  2FME A;  1VFX A;  1D1A A;  4ZCA A;  5LT0 A;  3DC4 A;  1D0X A;  1YRS A;  3BFN A;  3K5E A;  4PFP A;  1MMA A;  2NCD A;  2V26 A;  5LT4 A;  2X7D A;  4B7B A;  1LVK A;  2Q2Y A;  4A1Z A;  2G1Q A;  2MYS A;  4DBQ A;  1D1B A;  4A28 A;  2ZFK A;  1BR1 A;  1FMW A;  4A5Y A;  2X7C A;  4PJJ A;  4PJL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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