2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
1FMVA 4E7ZA 4PJMA 2UYIA 3L9HA 4ANJA 1MNEA 4E7SA 3CNZA 4PFPA 1VFWA 2ZFLA 4Y05A 3K5EA 4GKRA 2X51A 3LREA 1YRSA 2XT3A 2IEHA 2X7CA 2ZFKA 1MMAA 1F9TA 2Y5WA 5LT2A 2ZFIA 3U06A 1V8JA 3COBA 2KINA 5GSZA 1GOJA 2NCDA 4A28A 2FMEA 4PJLA 1BG2A 1MMNA 2VASA 1F9VA 3X2TA 2HEHA 3KARA 2UYMA 1MKJA 4AP0A 1D0YA 4ZHIA 1X88A 3BFNA 2VB6A 2V26A 4A5YA 3KINA 2G1QA 1BR1A 4A14A 4DBRA 4A51A 3KENA 2MYSA 3DC4A 3HQDA 2XAEA 1D1CA 3WPNA 1N6MA 4PFOA 1D1AA 1D1BA 1G8XA 1Q0BA 2WOGA 5LT3A 2OWMA 4DBQA 2X7EA 2GRYA 3GBJA 4FRZA 4BBGA 1D0XA 4PK4A 1VFXA 4BXNA 5LT4A 2Y65A 2VVGA 2X7DA 1BR4A 1LVKA 5HLEA 2PG2A 4HNAK 1SDMA 1KK7A 3WRDA 3DCBA 3PXNA 1II6A 1T5CA 5LT1A 2Q2ZA 3NWNA 3ZFDA 1I6IA 1LKXA 1CZ7A 4ZCAA 1F9UA 3K3BA 4BN2A 1V8KA 1F9WA 2FL6A 1RY6A 3T0QA 3B6UA 3B6VA 1I5SA 4A1ZA 1BR2A 2FKYA 2ZFJA 1MMGA 5LT0A 3CJOA 3ZCWA 4A50A 1D0ZA 1VFZA 1FMWA 4AS7A 3H4SA 2ZFMA 2X2RA 2FL2A 2Q2YA 2GM1A 3L1CA 4UBFA 4LNUK 1MMDA 4B7BA 4ETPA 4H1GA 1VFVA 1VOMA 4PJJA 3ZFCA 4PJNA
chains in the Genus database with same CATH superfamily
1FMVA 4E7ZA 4PJMA 2UYIA 3L9HA 4ANJA 1MNEA 4E7SA 3CNZA 4PFPA 1VFWA 2ZFLA 4Y05A 3K5EA 4GKRA 2X51A 3LREA 1YRSA 2XT3A 2IEHA 2X7CA 2ZFKA 1MMAA 1F9TA 2Y5WA 5LT2A 2ZFIA 3U06A 1V8JA 3COBA 2KINA 5GSZA 1GOJA 2NCDA 4A28A 2FMEA 4PJLA 1BG2A 1MMNA 2VASA 1F9VA 3X2TA 2HEHA 3KARA 2UYMA 1MKJA 4AP0A 1D0YA 4ZHIA 1X88A 3BFNA 2VB6A 2V26A 4A5YA 3KINA 2G1QA 1BR1A 4A14A 4DBRA 4A51A 3KENA 2MYSA 3DC4A 3HQDA 2XAEA 1D1CA 3WPNA 1N6MA 4PFOA 1D1AA 1D1BA 1G8XA 1Q0BA 2WOGA 5LT3A 2OWMA 4DBQA 2X7EA 2GRYA 3GBJA 4FRZA 4BBGA 1D0XA 4PK4A 1VFXA 4GKPA 4BXNA 5LT4A 2Y65A 2VVGA 2X7DA 1BR4A 1LVKA 5HLEA 2PG2A 4HNAK 1SDMA 1KK7A 3WRDA 3DCBA 3PXNA 1II6A 1T5CA 5LT1A 2Q2ZA 3NWNA 3ZFDA 1I6IA 1LKXA 1CZ7A 4ZCAA 4ETPB 1F9UA 3K3BA 4BN2A 1V8KA 1F9WA 2FL6A 1RY6A 3T0QA 3B6UA 3B6VA 1I5SA 4A1ZA 1BR2A 2FKYA 2ZFJA 1MMGA 5LT0A 3CJOA 3ZCWA 4A50A 1D0ZA 1VFZA 1FMWA 4AS7A 3H4SA 2ZFMA 2X2RA 2FL2A 2Q2YA 2GM1A 4GKQA 3L1CA 4UBFA 4LNUK 1MMDA 4B7BA 4ETPA 2O0AA 4H1GA 1VFVA 1VOMA 4PJJA 3ZFCA 4PJNA
chains in the Genus database with same CATH topology
1FMVA 4E7ZA 4PJMA 2UYIA 3L9HA 4ANJA 1MNEA 4E7SA 3CNZA 4PFPA 1VFWA 2ZFLA 4Y05A 3K5EA 4GKRA 2X51A 3LREA 1YRSA 2XT3A 2IEHA 2X7CA 2ZFKA 1MMAA 1F9TA 2Y5WA 5LT2A 2ZFIA 3U06A 1V8JA 3COBA 2KINA 5GSZA 1GOJA 2NCDA 4A28A 2FMEA 4PJLA 1BG2A 1MMNA 2VASA 1F9VA 3X2TA 2HEHA 3KARA 2UYMA 1MKJA 4AP0A 1D0YA 4ZHIA 1X88A 3BFNA 2VB6A 2V26A 4A5YA 3KINA 2G1QA 1BR1A 4A14A 4DBRA 4A51A 3KENA 2MYSA 3DC4A 3HQDA 2XAEA 1D1CA 3WPNA 1N6MA 4PFOA 1D1AA 1D1BA 1G8XA 1Q0BA 2WOGA 5LT3A 2OWMA 4DBQA 2X7EA 2GRYA 3GBJA 4FRZA 4BBGA 1D0XA 4PK4A 1VFXA 4BXNA 5LT4A 2Y65A 2VVGA 2X7DA 1BR4A 1LVKA 5HLEA 2PG2A 4HNAK 1SDMA 1KK7A 3WRDA 3DCBA 3PXNA 1II6A 1T5CA 5LT1A 2Q2ZA 3NWNA 3ZFDA 1I6IA 1LKXA 1CZ7A 4ZCAA 1F9UA 3K3BA 4BN2A 1V8KA 1F9WA 2FL6A 1RY6A 3T0QA 3B6UA 3B6VA 1I5SA 4A1ZA 1BR2A 2FKYA 2ZFJA 1MMGA 5LT0A 3CJOA 3ZCWA 4A50A 1D0ZA 1VFZA 1FMWA 4AS7A 3H4SA 2ZFMA 2X2RA 2FL2A 2Q2YA 2GM1A 3L1CA 4UBFA 4LNUK 1MMDA 4B7BA 4ETPA 4H1GA 1VFVA 1VOMA 4PJJA 3ZFCA 4PJNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FMV A;  4E7Z A;  4PJM A;  2UYI A;  3L9H A;  4ANJ A;  1MNE A;  4E7S A;  3CNZ A;  4PFP A;  1VFW A;  2ZFL A;  4Y05 A;  3K5E A;  4GKR A;  2X51 A;  3LRE A;  1YRS A;  2XT3 A;  2IEH A;  2X7C A;  2ZFK A;  1MMA A;  1F9T A;  2Y5W A;  5LT2 A;  2ZFI A;  3U06 A;  1V8J A;  3COB A;  2KIN A;  5GSZ A;  1GOJ A;  2NCD A;  4A28 A;  2FME A;  4PJL A;  1BG2 A;  1MMN A;  2VAS A;  1F9V A;  3X2T A;  2HEH A;  3KAR A;  2UYM A;  1MKJ A;  4AP0 A;  1D0Y A;  4ZHI A;  1X88 A;  3BFN A;  2VB6 A;  2V26 A;  4A5Y A;  3KIN A;  2G1Q A;  1BR1 A;  4A14 A;  4DBR A;  4A51 A;  3KEN A;  2MYS A;  3DC4 A;  3HQD A;  2XAE A;  1D1C A;  3WPN A;  1N6M A;  4PFO A;  1D1A A;  1D1B A;  1G8X A;  1Q0B A;  2WOG A;  5LT3 A;  2OWM A;  4DBQ A;  2X7E A;  2GRY A;  3GBJ A;  4FRZ A;  4BBG A;  1D0X A;  4PK4 A;  1VFX A;  4BXN A;  5LT4 A;  2Y65 A;  2VVG A;  2X7D A;  1BR4 A;  1LVK A;  5HLE A;  2PG2 A;  4HNA K;  1SDM A;  1KK7 A;  3WRD A;  3DCB A;  3PXN A;  1II6 A;  1T5C A;  5LT1 A;  2Q2Z A;  3NWN A;  3ZFD A;  1I6I A;  1LKX A;  1CZ7 A;  4ZCA A;  1F9U A;  3K3B A;  4BN2 A;  1V8K A;  1F9W A;  2FL6 A;  1RY6 A;  3T0Q A;  3B6U A;  3B6V A;  1I5S A;  4A1Z A;  1BR2 A;  2FKY A;  2ZFJ A;  1MMG A;  5LT0 A;  3CJO A;  3ZCW A;  4A50 A;  1D0Z A;  1VFZ A;  1FMW A;  4AS7 A;  3H4S A;  2ZFM A;  2X2R A;  2FL2 A;  2Q2Y A;  2GM1 A;  3L1C A;  4UBF A;  4LNU K;  1MMD A;  4B7B A;  4ETP A;  4H1G A;  1VFV A;  1VOM A;  4PJJ A;  3ZFC A;  4PJN A; 
#chains in the Genus database with same CATH topology
 1FMV A;  4E7Z A;  4PJM A;  2UYI A;  3L9H A;  4ANJ A;  1MNE A;  4E7S A;  3CNZ A;  4PFP A;  1VFW A;  2ZFL A;  4Y05 A;  3K5E A;  4GKR A;  2X51 A;  3LRE A;  1YRS A;  2XT3 A;  2IEH A;  2X7C A;  2ZFK A;  1MMA A;  1F9T A;  2Y5W A;  5LT2 A;  2ZFI A;  3U06 A;  1V8J A;  3COB A;  2KIN A;  5GSZ A;  1GOJ A;  2NCD A;  4A28 A;  2FME A;  4PJL A;  1BG2 A;  1MMN A;  2VAS A;  1F9V A;  3X2T A;  2HEH A;  3KAR A;  2UYM A;  1MKJ A;  4AP0 A;  1D0Y A;  4ZHI A;  1X88 A;  3BFN A;  2VB6 A;  2V26 A;  4A5Y A;  3KIN A;  2G1Q A;  1BR1 A;  4A14 A;  4DBR A;  4A51 A;  3KEN A;  2MYS A;  3DC4 A;  3HQD A;  2XAE A;  1D1C A;  3WPN A;  1N6M A;  4PFO A;  1D1A A;  1D1B A;  1G8X A;  1Q0B A;  2WOG A;  5LT3 A;  2OWM A;  4DBQ A;  2X7E A;  2GRY A;  3GBJ A;  4FRZ A;  4BBG A;  1D0X A;  4PK4 A;  1VFX A;  4GKP A;  4BXN A;  5LT4 A;  2Y65 A;  2VVG A;  2X7D A;  1BR4 A;  1LVK A;  5HLE A;  2PG2 A;  4HNA K;  1SDM A;  1KK7 A;  3WRD A;  3DCB A;  3PXN A;  1II6 A;  1T5C A;  5LT1 A;  2Q2Z A;  3NWN A;  3ZFD A;  1I6I A;  1LKX A;  1CZ7 A;  4ZCA A;  4ETP B;  1F9U A;  3K3B A;  4BN2 A;  1V8K A;  1F9W A;  2FL6 A;  1RY6 A;  3T0Q A;  3B6U A;  3B6V A;  1I5S A;  4A1Z A;  1BR2 A;  2FKY A;  2ZFJ A;  1MMG A;  5LT0 A;  3CJO A;  3ZCW A;  4A50 A;  1D0Z A;  1VFZ A;  1FMW A;  4AS7 A;  3H4S A;  2ZFM A;  2X2R A;  2FL2 A;  2Q2Y A;  2GM1 A;  4GKQ A;  3L1C A;  4UBF A;  4LNU K;  1MMD A;  4B7B A;  4ETP A;  2O0A A;  4H1G A;  1VFV A;  1VOM A;  4PJJ A;  3ZFC A;  4PJN A; 
#chains in the Genus database with same CATH homology
 1FMV A;  4E7Z A;  4PJM A;  2UYI A;  3L9H A;  4ANJ A;  1MNE A;  4E7S A;  3CNZ A;  4PFP A;  1VFW A;  2ZFL A;  4Y05 A;  3K5E A;  4GKR A;  2X51 A;  3LRE A;  1YRS A;  2XT3 A;  2IEH A;  2X7C A;  2ZFK A;  1MMA A;  1F9T A;  2Y5W A;  5LT2 A;  2ZFI A;  3U06 A;  1V8J A;  3COB A;  2KIN A;  5GSZ A;  1GOJ A;  2NCD A;  4A28 A;  2FME A;  4PJL A;  1BG2 A;  1MMN A;  2VAS A;  1F9V A;  3X2T A;  2HEH A;  3KAR A;  2UYM A;  1MKJ A;  4AP0 A;  1D0Y A;  4ZHI A;  1X88 A;  3BFN A;  2VB6 A;  2V26 A;  4A5Y A;  3KIN A;  2G1Q A;  1BR1 A;  4A14 A;  4DBR A;  4A51 A;  3KEN A;  2MYS A;  3DC4 A;  3HQD A;  2XAE A;  1D1C A;  3WPN A;  1N6M A;  4PFO A;  1D1A A;  1D1B A;  1G8X A;  1Q0B A;  2WOG A;  5LT3 A;  2OWM A;  4DBQ A;  2X7E A;  2GRY A;  3GBJ A;  4FRZ A;  4BBG A;  1D0X A;  4PK4 A;  1VFX A;  4BXN A;  5LT4 A;  2Y65 A;  2VVG A;  2X7D A;  1BR4 A;  1LVK A;  5HLE A;  2PG2 A;  4HNA K;  1SDM A;  1KK7 A;  3WRD A;  3DCB A;  3PXN A;  1II6 A;  1T5C A;  5LT1 A;  2Q2Z A;  3NWN A;  3ZFD A;  1I6I A;  1LKX A;  1CZ7 A;  4ZCA A;  1F9U A;  3K3B A;  4BN2 A;  1V8K A;  1F9W A;  2FL6 A;  1RY6 A;  3T0Q A;  3B6U A;  3B6V A;  1I5S A;  4A1Z A;  1BR2 A;  2FKY A;  2ZFJ A;  1MMG A;  5LT0 A;  3CJO A;  3ZCW A;  4A50 A;  1D0Z A;  1VFZ A;  1FMW A;  4AS7 A;  3H4S A;  2ZFM A;  2X2R A;  2FL2 A;  2Q2Y A;  2GM1 A;  3L1C A;  4UBF A;  4LNU K;  1MMD A;  4B7B A;  4ETP A;  4H1G A;  1VFV A;  1VOM A;  4PJJ A;  3ZFC A;  4PJN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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