2X2RA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid
Total Genus 111
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
349
structure length
331
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
source organism Homo sapiens
total genus 111
structure length 331
sequence length 349
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x2rA00
2XAEA 1MMGA 1T5CA 2X7DA 2FMEA 4BBGA 4A51A 2HEHA 3CJOA 3LREA 4PFOA 1LVKA 2V26A 4PJNA 3WPNA 1VFVA 3CNZA 2OWMA 5LT1A 2ZFIA 1N6MA 1MNEA 1D0XA 1MMDA 2NCDA 4ZCAA 4A1ZA 3KENA 3B6VA 4HNAK 4A5YA 2UYMA 3DCBA 2PG2A 1CZ7A 5LT2A 4A28A 1BR2A 4PK4A 1BR4A 1I6IA 2WOGA 1X88A 3U06A 3K5EA 4ANJA 1MMNA 4E7ZA 1D0ZA 4UBFA 4LNUK 1I5SA 1FMVA 2UYIA 5LT0A 2ZFJA 2ZFMA 1KK7A 5HLEA 1YRSA 3ZFDA 1BR1A 1F9VA 2VASA 2VVGA 1LKXA 1D1CA 2MYSA 1G8XA 3KARA 3PXNA 4E7SA 4PJJA 1VOMA 3B6UA 3BFNA 1MMAA 2GM1A 2Y5WA 4H1GA 4A50A 4A14A 3L1CA 2XT3A 3ZFCA 3WRDA 1F9TA 1FMWA 1V8JA 3COBA 2X2RA 1VFZA 4ETPA 2FL2A 3T0QA 5GSZA 4Y05A 5LT3A 3ZCWA 3H4SA 3NWNA 4DBRA 3L9HA 1D0YA 2Q2ZA 4PJLA 3HQDA 1MKJA 3KINA 2ZFKA 2Y65A 3X2TA 4PJMA 2X7CA 2X51A 1RY6A 2IEHA 4GKRA 4ZHIA 1F9UA 1F9WA 1II6A 2KINA 1VFWA 1Q0BA 3GBJA 4PFPA 1D1BA 2FL6A 2GRYA 1VFXA 2Q2YA 4B7BA 2X7EA 1BG2A 4BN2A 4FRZA 4AP0A 2VB6A 4DBQA 3DC4A 3K3BA 1D1AA 5LT4A 1GOJA 2FKYA 1SDMA 4BXNA 4AS7A 2G1QA 2ZFLA 1V8KA
chains in the Genus database with same CATH superfamily
2XAEA 1MMGA 1T5CA 2X7DA 2FMEA 4BBGA 4A51A 2HEHA 3CJOA 3LREA 4PFOA 1LVKA 2V26A 4PJNA 3WPNA 1VFVA 3CNZA 2OWMA 5LT1A 2ZFIA 1N6MA 1MNEA 1D0XA 1MMDA 2NCDA 4ZCAA 4A1ZA 3KENA 3B6VA 4HNAK 4A5YA 2UYMA 3DCBA 2PG2A 1CZ7A 5LT2A 4A28A 1BR2A 4PK4A 1BR4A 1I6IA 2WOGA 1X88A 3U06A 3K5EA 4ANJA 1MMNA 4ETPB 4E7ZA 1D0ZA 4UBFA 4LNUK 1I5SA 1FMVA 2UYIA 5LT0A 2ZFJA 2ZFMA 1KK7A 5HLEA 1YRSA 3ZFDA 1BR1A 1F9VA 2VASA 2VVGA 1LKXA 1D1CA 2MYSA 1G8XA 3KARA 3PXNA 4GKQA 4E7SA 4PJJA 1VOMA 3B6UA 3BFNA 1MMAA 2GM1A 2Y5WA 4H1GA 4A50A 4A14A 3L1CA 2XT3A 3ZFCA 3WRDA 1F9TA 1FMWA 1V8JA 3COBA 2X2RA 1VFZA 4ETPA 2FL2A 3T0QA 5GSZA 4GKPA 4Y05A 5LT3A 3ZCWA 2O0AA 3H4SA 3NWNA 4DBRA 3L9HA 1D0YA 2Q2ZA 4PJLA 3HQDA 1MKJA 3KINA 2ZFKA 2Y65A 3X2TA 4PJMA 2X7CA 2X51A 1RY6A 2IEHA 4GKRA 4ZHIA 1F9UA 1F9WA 1II6A 2KINA 1VFWA 1Q0BA 3GBJA 4PFPA 1D1BA 2FL6A 2GRYA 1VFXA 2Q2YA 4B7BA 2X7EA 1BG2A 4BN2A 4FRZA 4AP0A 2VB6A 4DBQA 3DC4A 3K3BA 1D1AA 5LT4A 1GOJA 2FKYA 1SDMA 4BXNA 4AS7A 2G1QA 2ZFLA 1V8KA
chains in the Genus database with same CATH topology
2XAEA 1MMGA 1T5CA 2X7DA 2FMEA 4BBGA 4A51A 2HEHA 3CJOA 3LREA 4PFOA 1LVKA 2V26A 4PJNA 3WPNA 1VFVA 3CNZA 2OWMA 5LT1A 2ZFIA 1N6MA 1MNEA 1D0XA 1MMDA 2NCDA 4ZCAA 4A1ZA 3KENA 3B6VA 4HNAK 4A5YA 2UYMA 3DCBA 2PG2A 1CZ7A 5LT2A 4A28A 1BR2A 4PK4A 1BR4A 1I6IA 2WOGA 1X88A 3U06A 3K5EA 4ANJA 1MMNA 4E7ZA 1D0ZA 4UBFA 4LNUK 1I5SA 1FMVA 2UYIA 5LT0A 2ZFJA 2ZFMA 1KK7A 5HLEA 1YRSA 3ZFDA 1BR1A 1F9VA 2VASA 2VVGA 1LKXA 1D1CA 2MYSA 1G8XA 3KARA 3PXNA 4E7SA 4PJJA 1VOMA 3B6UA 3BFNA 1MMAA 2GM1A 2Y5WA 4H1GA 4A50A 4A14A 3L1CA 2XT3A 3ZFCA 3WRDA 1F9TA 1FMWA 1V8JA 3COBA 2X2RA 1VFZA 4ETPA 2FL2A 3T0QA 5GSZA 4Y05A 5LT3A 3ZCWA 3H4SA 3NWNA 4DBRA 3L9HA 1D0YA 2Q2ZA 4PJLA 3HQDA 1MKJA 3KINA 2ZFKA 2Y65A 3X2TA 4PJMA 2X7CA 2X51A 1RY6A 2IEHA 4GKRA 4ZHIA 1F9UA 1F9WA 1II6A 2KINA 1VFWA 1Q0BA 3GBJA 4PFPA 1D1BA 2FL6A 2GRYA 1VFXA 2Q2YA 4B7BA 2X7EA 1BG2A 4BN2A 4FRZA 4AP0A 2VB6A 4DBQA 3DC4A 3K3BA 1D1AA 5LT4A 1GOJA 2FKYA 1SDMA 4BXNA 4AS7A 2G1QA 2ZFLA 1V8KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XAE A;  1MMG A;  1T5C A;  2X7D A;  2FME A;  4BBG A;  4A51 A;  2HEH A;  3CJO A;  3LRE A;  4PFO A;  1LVK A;  2V26 A;  4PJN A;  3WPN A;  1VFV A;  3CNZ A;  2OWM A;  5LT1 A;  2ZFI A;  1N6M A;  1MNE A;  1D0X A;  1MMD A;  2NCD A;  4ZCA A;  4A1Z A;  3KEN A;  3B6V A;  4HNA K;  4A5Y A;  2UYM A;  3DCB A;  2PG2 A;  1CZ7 A;  5LT2 A;  4A28 A;  1BR2 A;  4PK4 A;  1BR4 A;  1I6I A;  2WOG A;  1X88 A;  3U06 A;  3K5E A;  4ANJ A;  1MMN A;  4E7Z A;  1D0Z A;  4UBF A;  4LNU K;  1I5S A;  1FMV A;  2UYI A;  5LT0 A;  2ZFJ A;  2ZFM A;  1KK7 A;  5HLE A;  1YRS A;  3ZFD A;  1BR1 A;  1F9V A;  2VAS A;  2VVG A;  1LKX A;  1D1C A;  2MYS A;  1G8X A;  3KAR A;  3PXN A;  4E7S A;  4PJJ A;  1VOM A;  3B6U A;  3BFN A;  1MMA A;  2GM1 A;  2Y5W A;  4H1G A;  4A50 A;  4A14 A;  3L1C A;  2XT3 A;  3ZFC A;  3WRD A;  1F9T A;  1FMW A;  1V8J A;  3COB A;  2X2R A;  1VFZ A;  4ETP A;  2FL2 A;  3T0Q A;  5GSZ A;  4Y05 A;  5LT3 A;  3ZCW A;  3H4S A;  3NWN A;  4DBR A;  3L9H A;  1D0Y A;  2Q2Z A;  4PJL A;  3HQD A;  1MKJ A;  3KIN A;  2ZFK A;  2Y65 A;  3X2T A;  4PJM A;  2X7C A;  2X51 A;  1RY6 A;  2IEH A;  4GKR A;  4ZHI A;  1F9U A;  1F9W A;  1II6 A;  2KIN A;  1VFW A;  1Q0B A;  3GBJ A;  4PFP A;  1D1B A;  2FL6 A;  2GRY A;  1VFX A;  2Q2Y A;  4B7B A;  2X7E A;  1BG2 A;  4BN2 A;  4FRZ A;  4AP0 A;  2VB6 A;  4DBQ A;  3DC4 A;  3K3B A;  1D1A A;  5LT4 A;  1GOJ A;  2FKY A;  1SDM A;  4BXN A;  4AS7 A;  2G1Q A;  2ZFL A;  1V8K A; 
#chains in the Genus database with same CATH topology
 2XAE A;  1MMG A;  1T5C A;  2X7D A;  2FME A;  4BBG A;  4A51 A;  2HEH A;  3CJO A;  3LRE A;  4PFO A;  1LVK A;  2V26 A;  4PJN A;  3WPN A;  1VFV A;  3CNZ A;  2OWM A;  5LT1 A;  2ZFI A;  1N6M A;  1MNE A;  1D0X A;  1MMD A;  2NCD A;  4ZCA A;  4A1Z A;  3KEN A;  3B6V A;  4HNA K;  4A5Y A;  2UYM A;  3DCB A;  2PG2 A;  1CZ7 A;  5LT2 A;  4A28 A;  1BR2 A;  4PK4 A;  1BR4 A;  1I6I A;  2WOG A;  1X88 A;  3U06 A;  3K5E A;  4ANJ A;  1MMN A;  4ETP B;  4E7Z A;  1D0Z A;  4UBF A;  4LNU K;  1I5S A;  1FMV A;  2UYI A;  5LT0 A;  2ZFJ A;  2ZFM A;  1KK7 A;  5HLE A;  1YRS A;  3ZFD A;  1BR1 A;  1F9V A;  2VAS A;  2VVG A;  1LKX A;  1D1C A;  2MYS A;  1G8X A;  3KAR A;  3PXN A;  4GKQ A;  4E7S A;  4PJJ A;  1VOM A;  3B6U A;  3BFN A;  1MMA A;  2GM1 A;  2Y5W A;  4H1G A;  4A50 A;  4A14 A;  3L1C A;  2XT3 A;  3ZFC A;  3WRD A;  1F9T A;  1FMW A;  1V8J A;  3COB A;  2X2R A;  1VFZ A;  4ETP A;  2FL2 A;  3T0Q A;  5GSZ A;  4GKP A;  4Y05 A;  5LT3 A;  3ZCW A;  2O0A A;  3H4S A;  3NWN A;  4DBR A;  3L9H A;  1D0Y A;  2Q2Z A;  4PJL A;  3HQD A;  1MKJ A;  3KIN A;  2ZFK A;  2Y65 A;  3X2T A;  4PJM A;  2X7C A;  2X51 A;  1RY6 A;  2IEH A;  4GKR A;  4ZHI A;  1F9U A;  1F9W A;  1II6 A;  2KIN A;  1VFW A;  1Q0B A;  3GBJ A;  4PFP A;  1D1B A;  2FL6 A;  2GRY A;  1VFX A;  2Q2Y A;  4B7B A;  2X7E A;  1BG2 A;  4BN2 A;  4FRZ A;  4AP0 A;  2VB6 A;  4DBQ A;  3DC4 A;  3K3B A;  1D1A A;  5LT4 A;  1GOJ A;  2FKY A;  1SDM A;  4BXN A;  4AS7 A;  2G1Q A;  2ZFL A;  1V8K A; 
#chains in the Genus database with same CATH homology
 2XAE A;  1MMG A;  1T5C A;  2X7D A;  2FME A;  4BBG A;  4A51 A;  2HEH A;  3CJO A;  3LRE A;  4PFO A;  1LVK A;  2V26 A;  4PJN A;  3WPN A;  1VFV A;  3CNZ A;  2OWM A;  5LT1 A;  2ZFI A;  1N6M A;  1MNE A;  1D0X A;  1MMD A;  2NCD A;  4ZCA A;  4A1Z A;  3KEN A;  3B6V A;  4HNA K;  4A5Y A;  2UYM A;  3DCB A;  2PG2 A;  1CZ7 A;  5LT2 A;  4A28 A;  1BR2 A;  4PK4 A;  1BR4 A;  1I6I A;  2WOG A;  1X88 A;  3U06 A;  3K5E A;  4ANJ A;  1MMN A;  4E7Z A;  1D0Z A;  4UBF A;  4LNU K;  1I5S A;  1FMV A;  2UYI A;  5LT0 A;  2ZFJ A;  2ZFM A;  1KK7 A;  5HLE A;  1YRS A;  3ZFD A;  1BR1 A;  1F9V A;  2VAS A;  2VVG A;  1LKX A;  1D1C A;  2MYS A;  1G8X A;  3KAR A;  3PXN A;  4E7S A;  4PJJ A;  1VOM A;  3B6U A;  3BFN A;  1MMA A;  2GM1 A;  2Y5W A;  4H1G A;  4A50 A;  4A14 A;  3L1C A;  2XT3 A;  3ZFC A;  3WRD A;  1F9T A;  1FMW A;  1V8J A;  3COB A;  2X2R A;  1VFZ A;  4ETP A;  2FL2 A;  3T0Q A;  5GSZ A;  4Y05 A;  5LT3 A;  3ZCW A;  3H4S A;  3NWN A;  4DBR A;  3L9H A;  1D0Y A;  2Q2Z A;  4PJL A;  3HQD A;  1MKJ A;  3KIN A;  2ZFK A;  2Y65 A;  3X2T A;  4PJM A;  2X7C A;  2X51 A;  1RY6 A;  2IEH A;  4GKR A;  4ZHI A;  1F9U A;  1F9W A;  1II6 A;  2KIN A;  1VFW A;  1Q0B A;  3GBJ A;  4PFP A;  1D1B A;  2FL6 A;  2GRY A;  1VFX A;  2Q2Y A;  4B7B A;  2X7E A;  1BG2 A;  4BN2 A;  4FRZ A;  4AP0 A;  2VB6 A;  4DBQ A;  3DC4 A;  3K3B A;  1D1A A;  5LT4 A;  1GOJ A;  2FKY A;  1SDM A;  4BXN A;  4AS7 A;  2G1Q A;  2ZFL A;  1V8K A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...