2X7EA

Crystal structure of human kinesin eg5 in complex with (r)-fluorastrol
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
333
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
total genus 104
structure length 333
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7eA00
2X7DA 1YRSA 4DBRA 1VFXA 2NCDA 4A50A 1F9WA 2UYMA 4GKRA 5LT1A 3HQDA 4PJLA 4BBGA 2FMEA 2FKYA 1F9UA 1I5SA 1KK7A 2PG2A 3KINA 3NWNA 4A5YA 2OWMA 2ZFLA 1D0XA 1LVKA 2XAEA 3ZFCA 1FMVA 1LKXA 2ZFJA 4HNAK 2ZFMA 1FMWA 3DCBA 4ETPA 1D0ZA 2XT3A 4A51A 1BR4A 1F9TA 3BFNA 2VASA 2HEHA 1MMGA 1SDMA 4A28A 4BN2A 5GSZA 4PK4A 1MMDA 2Y65A 3COBA 3T0QA 1BR1A 1MMAA 1D1CA 3CJOA 2UYIA 3K5EA 1VFZA 1F9VA 2FL2A 4PJMA 2Q2YA 4PFPA 2X7EA 2X2RA 2FL6A 3L9HA 4AP0A 5LT0A 3H4SA 3PXNA 4B7BA 3KENA 4ZHIA 1BG2A 3LREA 2X51A 1BR2A 1II6A 2IEHA 2X7CA 2G1QA 2ZFIA 3KARA 4Y05A 4E7ZA 1CZ7A 1GOJA 2WOGA 4H1GA 2V26A 5LT4A 3B6VA 2ZFKA 1I6IA 3K3BA 1VFVA 3GBJA 4PJJA 2GRYA 1MMNA 3B6UA 3DC4A 1V8JA 4A14A 4UBFA 2VB6A 1X88A 1Q0BA 2GM1A 3WPNA 1T5CA 3ZFDA 4ZCAA 4AS7A 1D1BA 4DBQA 4FRZA 1MKJA 1VFWA 5LT2A 3X2TA 3U06A 1RY6A 5HLEA 2Y5WA 4LNUK 2VVGA 1N6MA 1VOMA 4BXNA 3WRDA 4E7SA 4A1ZA 1D1AA 3L1CA 4ANJA 4PJNA 2Q2ZA 5LT3A 1G8XA 1V8KA 3CNZA 2MYSA 1D0YA 3ZCWA 2KINA 1MNEA 4PFOA
chains in the Genus database with same CATH superfamily
2X7DA 1YRSA 4DBRA 1VFXA 2NCDA 4A50A 1F9WA 2UYMA 4GKRA 5LT1A 3HQDA 4PJLA 4BBGA 2FMEA 2FKYA 1F9UA 1I5SA 1KK7A 2PG2A 3KINA 3NWNA 4A5YA 2OWMA 2ZFLA 1D0XA 1LVKA 2XAEA 3ZFCA 1FMVA 1LKXA 2ZFJA 4HNAK 2ZFMA 1FMWA 3DCBA 4ETPA 1D0ZA 2XT3A 4A51A 1BR4A 1F9TA 3BFNA 2VASA 2HEHA 1MMGA 1SDMA 4A28A 4BN2A 5GSZA 4PK4A 1MMDA 2Y65A 3COBA 3T0QA 1BR1A 1MMAA 1D1CA 3CJOA 2UYIA 4ETPB 3K5EA 1VFZA 1F9VA 2FL2A 4PJMA 2Q2YA 4PFPA 2X7EA 2X2RA 2FL6A 4GKQA 3L9HA 4AP0A 5LT0A 3H4SA 3PXNA 4B7BA 3KENA 4ZHIA 1BG2A 3LREA 2X51A 1BR2A 1II6A 2IEHA 2X7CA 2G1QA 2ZFIA 3KARA 4Y05A 4E7ZA 1CZ7A 1GOJA 2WOGA 4H1GA 2V26A 5LT4A 3B6VA 2ZFKA 1I6IA 3K3BA 1VFVA 3GBJA 4PJJA 2GRYA 1MMNA 3B6UA 3DC4A 1V8JA 4A14A 4UBFA 2VB6A 1X88A 1Q0BA 2GM1A 3WPNA 1T5CA 3ZFDA 4ZCAA 4AS7A 1D1BA 4DBQA 4FRZA 1MKJA 1VFWA 5LT2A 3X2TA 3U06A 1RY6A 5HLEA 2O0AA 2Y5WA 4LNUK 2VVGA 1N6MA 1VOMA 4BXNA 3WRDA 4E7SA 4A1ZA 1D1AA 3L1CA 4GKPA 4ANJA 4PJNA 2Q2ZA 5LT3A 1G8XA 1V8KA 3CNZA 2MYSA 1D0YA 3ZCWA 2KINA 1MNEA 4PFOA
chains in the Genus database with same CATH topology
2X7DA 1YRSA 4DBRA 1VFXA 2NCDA 4A50A 1F9WA 2UYMA 4GKRA 5LT1A 3HQDA 4PJLA 4BBGA 2FMEA 2FKYA 1F9UA 1I5SA 1KK7A 2PG2A 3KINA 3NWNA 4A5YA 2OWMA 2ZFLA 1D0XA 1LVKA 2XAEA 3ZFCA 1FMVA 1LKXA 2ZFJA 4HNAK 2ZFMA 1FMWA 3DCBA 4ETPA 1D0ZA 2XT3A 4A51A 1BR4A 1F9TA 3BFNA 2VASA 2HEHA 1MMGA 1SDMA 4A28A 4BN2A 5GSZA 4PK4A 1MMDA 2Y65A 3COBA 3T0QA 1BR1A 1MMAA 1D1CA 3CJOA 2UYIA 3K5EA 1VFZA 1F9VA 2FL2A 4PJMA 2Q2YA 4PFPA 2X7EA 2X2RA 2FL6A 3L9HA 4AP0A 5LT0A 3H4SA 3PXNA 4B7BA 3KENA 4ZHIA 1BG2A 3LREA 2X51A 1BR2A 1II6A 2IEHA 2X7CA 2G1QA 2ZFIA 3KARA 4Y05A 4E7ZA 1CZ7A 1GOJA 2WOGA 4H1GA 2V26A 5LT4A 3B6VA 2ZFKA 1I6IA 3K3BA 1VFVA 3GBJA 4PJJA 2GRYA 1MMNA 3B6UA 3DC4A 1V8JA 4A14A 4UBFA 2VB6A 1X88A 1Q0BA 2GM1A 3WPNA 1T5CA 3ZFDA 4ZCAA 4AS7A 1D1BA 4DBQA 4FRZA 1MKJA 1VFWA 5LT2A 3X2TA 3U06A 1RY6A 5HLEA 2Y5WA 4LNUK 2VVGA 1N6MA 1VOMA 4BXNA 3WRDA 4E7SA 4A1ZA 1D1AA 3L1CA 4ANJA 4PJNA 2Q2ZA 5LT3A 1G8XA 1V8KA 3CNZA 2MYSA 1D0YA 3ZCWA 2KINA 1MNEA 4PFOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X7D A;  1YRS A;  4DBR A;  1VFX A;  2NCD A;  4A50 A;  1F9W A;  2UYM A;  4GKR A;  5LT1 A;  3HQD A;  4PJL A;  4BBG A;  2FME A;  2FKY A;  1F9U A;  1I5S A;  1KK7 A;  2PG2 A;  3KIN A;  3NWN A;  4A5Y A;  2OWM A;  2ZFL A;  1D0X A;  1LVK A;  2XAE A;  3ZFC A;  1FMV A;  1LKX A;  2ZFJ A;  4HNA K;  2ZFM A;  1FMW A;  3DCB A;  4ETP A;  1D0Z A;  2XT3 A;  4A51 A;  1BR4 A;  1F9T A;  3BFN A;  2VAS A;  2HEH A;  1MMG A;  1SDM A;  4A28 A;  4BN2 A;  5GSZ A;  4PK4 A;  1MMD A;  2Y65 A;  3COB A;  3T0Q A;  1BR1 A;  1MMA A;  1D1C A;  3CJO A;  2UYI A;  3K5E A;  1VFZ A;  1F9V A;  2FL2 A;  4PJM A;  2Q2Y A;  4PFP A;  2X7E A;  2X2R A;  2FL6 A;  3L9H A;  4AP0 A;  5LT0 A;  3H4S A;  3PXN A;  4B7B A;  3KEN A;  4ZHI A;  1BG2 A;  3LRE A;  2X51 A;  1BR2 A;  1II6 A;  2IEH A;  2X7C A;  2G1Q A;  2ZFI A;  3KAR A;  4Y05 A;  4E7Z A;  1CZ7 A;  1GOJ A;  2WOG A;  4H1G A;  2V26 A;  5LT4 A;  3B6V A;  2ZFK A;  1I6I A;  3K3B A;  1VFV A;  3GBJ A;  4PJJ A;  2GRY A;  1MMN A;  3B6U A;  3DC4 A;  1V8J A;  4A14 A;  4UBF A;  2VB6 A;  1X88 A;  1Q0B A;  2GM1 A;  3WPN A;  1T5C A;  3ZFD A;  4ZCA A;  4AS7 A;  1D1B A;  4DBQ A;  4FRZ A;  1MKJ A;  1VFW A;  5LT2 A;  3X2T A;  3U06 A;  1RY6 A;  5HLE A;  2Y5W A;  4LNU K;  2VVG A;  1N6M A;  1VOM A;  4BXN A;  3WRD A;  4E7S A;  4A1Z A;  1D1A A;  3L1C A;  4ANJ A;  4PJN A;  2Q2Z A;  5LT3 A;  1G8X A;  1V8K A;  3CNZ A;  2MYS A;  1D0Y A;  3ZCW A;  2KIN A;  1MNE A;  4PFO A; 
#chains in the Genus database with same CATH topology
 2X7D A;  1YRS A;  4DBR A;  1VFX A;  2NCD A;  4A50 A;  1F9W A;  2UYM A;  4GKR A;  5LT1 A;  3HQD A;  4PJL A;  4BBG A;  2FME A;  2FKY A;  1F9U A;  1I5S A;  1KK7 A;  2PG2 A;  3KIN A;  3NWN A;  4A5Y A;  2OWM A;  2ZFL A;  1D0X A;  1LVK A;  2XAE A;  3ZFC A;  1FMV A;  1LKX A;  2ZFJ A;  4HNA K;  2ZFM A;  1FMW A;  3DCB A;  4ETP A;  1D0Z A;  2XT3 A;  4A51 A;  1BR4 A;  1F9T A;  3BFN A;  2VAS A;  2HEH A;  1MMG A;  1SDM A;  4A28 A;  4BN2 A;  5GSZ A;  4PK4 A;  1MMD A;  2Y65 A;  3COB A;  3T0Q A;  1BR1 A;  1MMA A;  1D1C A;  3CJO A;  2UYI A;  4ETP B;  3K5E A;  1VFZ A;  1F9V A;  2FL2 A;  4PJM A;  2Q2Y A;  4PFP A;  2X7E A;  2X2R A;  2FL6 A;  4GKQ A;  3L9H A;  4AP0 A;  5LT0 A;  3H4S A;  3PXN A;  4B7B A;  3KEN A;  4ZHI A;  1BG2 A;  3LRE A;  2X51 A;  1BR2 A;  1II6 A;  2IEH A;  2X7C A;  2G1Q A;  2ZFI A;  3KAR A;  4Y05 A;  4E7Z A;  1CZ7 A;  1GOJ A;  2WOG A;  4H1G A;  2V26 A;  5LT4 A;  3B6V A;  2ZFK A;  1I6I A;  3K3B A;  1VFV A;  3GBJ A;  4PJJ A;  2GRY A;  1MMN A;  3B6U A;  3DC4 A;  1V8J A;  4A14 A;  4UBF A;  2VB6 A;  1X88 A;  1Q0B A;  2GM1 A;  3WPN A;  1T5C A;  3ZFD A;  4ZCA A;  4AS7 A;  1D1B A;  4DBQ A;  4FRZ A;  1MKJ A;  1VFW A;  5LT2 A;  3X2T A;  3U06 A;  1RY6 A;  5HLE A;  2O0A A;  2Y5W A;  4LNU K;  2VVG A;  1N6M A;  1VOM A;  4BXN A;  3WRD A;  4E7S A;  4A1Z A;  1D1A A;  3L1C A;  4GKP A;  4ANJ A;  4PJN A;  2Q2Z A;  5LT3 A;  1G8X A;  1V8K A;  3CNZ A;  2MYS A;  1D0Y A;  3ZCW A;  2KIN A;  1MNE A;  4PFO A; 
#chains in the Genus database with same CATH homology
 2X7D A;  1YRS A;  4DBR A;  1VFX A;  2NCD A;  4A50 A;  1F9W A;  2UYM A;  4GKR A;  5LT1 A;  3HQD A;  4PJL A;  4BBG A;  2FME A;  2FKY A;  1F9U A;  1I5S A;  1KK7 A;  2PG2 A;  3KIN A;  3NWN A;  4A5Y A;  2OWM A;  2ZFL A;  1D0X A;  1LVK A;  2XAE A;  3ZFC A;  1FMV A;  1LKX A;  2ZFJ A;  4HNA K;  2ZFM A;  1FMW A;  3DCB A;  4ETP A;  1D0Z A;  2XT3 A;  4A51 A;  1BR4 A;  1F9T A;  3BFN A;  2VAS A;  2HEH A;  1MMG A;  1SDM A;  4A28 A;  4BN2 A;  5GSZ A;  4PK4 A;  1MMD A;  2Y65 A;  3COB A;  3T0Q A;  1BR1 A;  1MMA A;  1D1C A;  3CJO A;  2UYI A;  3K5E A;  1VFZ A;  1F9V A;  2FL2 A;  4PJM A;  2Q2Y A;  4PFP A;  2X7E A;  2X2R A;  2FL6 A;  3L9H A;  4AP0 A;  5LT0 A;  3H4S A;  3PXN A;  4B7B A;  3KEN A;  4ZHI A;  1BG2 A;  3LRE A;  2X51 A;  1BR2 A;  1II6 A;  2IEH A;  2X7C A;  2G1Q A;  2ZFI A;  3KAR A;  4Y05 A;  4E7Z A;  1CZ7 A;  1GOJ A;  2WOG A;  4H1G A;  2V26 A;  5LT4 A;  3B6V A;  2ZFK A;  1I6I A;  3K3B A;  1VFV A;  3GBJ A;  4PJJ A;  2GRY A;  1MMN A;  3B6U A;  3DC4 A;  1V8J A;  4A14 A;  4UBF A;  2VB6 A;  1X88 A;  1Q0B A;  2GM1 A;  3WPN A;  1T5C A;  3ZFD A;  4ZCA A;  4AS7 A;  1D1B A;  4DBQ A;  4FRZ A;  1MKJ A;  1VFW A;  5LT2 A;  3X2T A;  3U06 A;  1RY6 A;  5HLE A;  2Y5W A;  4LNU K;  2VVG A;  1N6M A;  1VOM A;  4BXN A;  3WRD A;  4E7S A;  4A1Z A;  1D1A A;  3L1C A;  4ANJ A;  4PJN A;  2Q2Z A;  5LT3 A;  1G8X A;  1V8K A;  3CNZ A;  2MYS A;  1D0Y A;  3ZCW A;  2KIN A;  1MNE A;  4PFO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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