2IEHA

Crystal structure of human kinesin eg5 in complex with (r)-mon97, a new monastrol-based inhibitor that binds as (r)-enantiomer
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
334
Chain Sequence
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Kinesin-like protein KIF11
publication title Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 334
sequence length 350
chains with identical sequence B
ec nomenclature ec 3.6.4.4: Transferred entry: 5.6.1.3.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2iehA00
2FKYA 3ZCWA 5LT4A 4FRZA 4GKRA 4LNUK 1BG2A 1I6IA 1LKXA 1Q0BA 1D0YA 4B7BA 1FMVA 3B6UA 2ZFLA 4A51A 3LREA 1VFWA 1BR1A 3KINA 3GBJA 3WRDA 1T5CA 3DC4A 1YRSA 3BFNA 1FMWA 1D0ZA 4PK4A 1MMNA 2OWMA 3KENA 5HLEA 1LVKA 2FL2A 1VFZA 2NCDA 2XT3A 1F9TA 1V8JA 4PFPA 1MMAA 5LT3A 2ZFJA 5GSZA 3K3BA 3HQDA 2ZFKA 4ANJA 2X7CA 1VFXA 2KINA 3X2TA 3U06A 3KARA 2VASA 2Q2YA 4ZHIA 4HNAK 3T0QA 2IEHA 2WOGA 3WPNA 4A1ZA 1VOMA 4DBQA 5LT2A 1RY6A 1CZ7A 4BBGA 2FMEA 1MNEA 4E7SA 1N6MA 1VFVA 2V26A 1BR4A 1KK7A 1MMDA 2XAEA 1D0XA 4PJMA 3COBA 2MYSA 2PG2A 4PFOA 4UBFA 4AS7A 2X7EA 4DBRA 2VVGA 1F9WA 1GOJA 3B6VA 3H4SA 2X51A 4A28A 4E7ZA 1F9VA 4A5YA 3PXNA 1MKJA 2X7DA 1I5SA 2GM1A 4PJNA 3K5EA 3ZFDA 1D1BA 2UYMA 1X88A 4AP0A 4BXNA 1D1AA 1D1CA 1F9UA 2FL6A 3L1CA 2Y5WA 3NWNA 1MMGA 4H1GA 3L9HA 2VB6A 4ZCAA 4BN2A 3CNZA 2Q2ZA 2UYIA 4A50A 2G1QA 2ZFMA 3DCBA 1II6A 4A14A 1G8XA 4ETPA 1SDMA 4PJJA 3ZFCA 1V8KA 5LT0A 4PJLA 3CJOA 2X2RA 5LT1A 2Y65A 2ZFIA 2GRYA 4Y05A 2HEHA 1BR2A
chains in the Genus database with same CATH superfamily
2FKYA 3ZCWA 5LT4A 4FRZA 4GKRA 4LNUK 1BG2A 1I6IA 1LKXA 1Q0BA 1D0YA 4B7BA 1FMVA 3B6UA 2ZFLA 4A51A 3LREA 1VFWA 1BR1A 3KINA 3GBJA 3WRDA 4ETPB 1T5CA 3DC4A 1YRSA 3BFNA 1FMWA 1D0ZA 4PK4A 1MMNA 2OWMA 3KENA 5HLEA 1LVKA 2FL2A 1VFZA 2NCDA 2XT3A 1F9TA 1V8JA 4PFPA 1MMAA 5LT3A 2ZFJA 5GSZA 3K3BA 3HQDA 2ZFKA 4ANJA 2X7CA 2O0AA 1VFXA 2KINA 3X2TA 3U06A 3KARA 2VASA 2Q2YA 4ZHIA 4HNAK 3T0QA 4GKPA 2IEHA 2WOGA 3WPNA 4A1ZA 1VOMA 4DBQA 4GKQA 5LT2A 1RY6A 1CZ7A 4BBGA 2FMEA 1MNEA 4E7SA 1N6MA 1VFVA 2V26A 1BR4A 1KK7A 1MMDA 2XAEA 1D0XA 4PJMA 3COBA 2MYSA 2PG2A 4PFOA 4UBFA 4AS7A 2X7EA 4DBRA 2VVGA 1F9WA 1GOJA 3B6VA 3H4SA 2X51A 4A28A 4E7ZA 1F9VA 4A5YA 3PXNA 1MKJA 2X7DA 1I5SA 2GM1A 4PJNA 3K5EA 3ZFDA 1D1BA 2UYMA 1X88A 4AP0A 4BXNA 1D1AA 1D1CA 1F9UA 2FL6A 3L1CA 2Y5WA 3NWNA 1MMGA 4H1GA 3L9HA 2VB6A 4ZCAA 4BN2A 3CNZA 2Q2ZA 2UYIA 4A50A 2G1QA 2ZFMA 3DCBA 1II6A 4A14A 1G8XA 4ETPA 1SDMA 4PJJA 3ZFCA 1V8KA 5LT0A 4PJLA 3CJOA 2X2RA 5LT1A 2Y65A 2ZFIA 2GRYA 4Y05A 2HEHA 1BR2A
chains in the Genus database with same CATH topology
2FKYA 3ZCWA 5LT4A 4FRZA 4GKRA 4LNUK 1BG2A 1I6IA 1LKXA 1Q0BA 1D0YA 4B7BA 1FMVA 3B6UA 2ZFLA 4A51A 3LREA 1VFWA 1BR1A 3KINA 3GBJA 3WRDA 1T5CA 3DC4A 1YRSA 3BFNA 1FMWA 1D0ZA 4PK4A 1MMNA 2OWMA 3KENA 5HLEA 1LVKA 2FL2A 1VFZA 2NCDA 2XT3A 1F9TA 1V8JA 4PFPA 1MMAA 5LT3A 2ZFJA 5GSZA 3K3BA 3HQDA 2ZFKA 4ANJA 2X7CA 1VFXA 2KINA 3X2TA 3U06A 3KARA 2VASA 2Q2YA 4ZHIA 4HNAK 3T0QA 2IEHA 2WOGA 3WPNA 4A1ZA 1VOMA 4DBQA 5LT2A 1RY6A 1CZ7A 4BBGA 2FMEA 1MNEA 4E7SA 1N6MA 1VFVA 2V26A 1BR4A 1KK7A 1MMDA 2XAEA 1D0XA 4PJMA 3COBA 2MYSA 2PG2A 4PFOA 4UBFA 4AS7A 2X7EA 4DBRA 2VVGA 1F9WA 1GOJA 3B6VA 3H4SA 2X51A 4A28A 4E7ZA 1F9VA 4A5YA 3PXNA 1MKJA 2X7DA 1I5SA 2GM1A 4PJNA 3K5EA 3ZFDA 1D1BA 2UYMA 1X88A 4AP0A 4BXNA 1D1AA 1D1CA 1F9UA 2FL6A 3L1CA 2Y5WA 3NWNA 1MMGA 4H1GA 3L9HA 2VB6A 4ZCAA 4BN2A 3CNZA 2Q2ZA 2UYIA 4A50A 2G1QA 2ZFMA 3DCBA 1II6A 4A14A 1G8XA 4ETPA 1SDMA 4PJJA 3ZFCA 1V8KA 5LT0A 4PJLA 3CJOA 2X2RA 5LT1A 2Y65A 2ZFIA 2GRYA 4Y05A 2HEHA 1BR2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FKY A;  3ZCW A;  5LT4 A;  4FRZ A;  4GKR A;  4LNU K;  1BG2 A;  1I6I A;  1LKX A;  1Q0B A;  1D0Y A;  4B7B A;  1FMV A;  3B6U A;  2ZFL A;  4A51 A;  3LRE A;  1VFW A;  1BR1 A;  3KIN A;  3GBJ A;  3WRD A;  1T5C A;  3DC4 A;  1YRS A;  3BFN A;  1FMW A;  1D0Z A;  4PK4 A;  1MMN A;  2OWM A;  3KEN A;  5HLE A;  1LVK A;  2FL2 A;  1VFZ A;  2NCD A;  2XT3 A;  1F9T A;  1V8J A;  4PFP A;  1MMA A;  5LT3 A;  2ZFJ A;  5GSZ A;  3K3B A;  3HQD A;  2ZFK A;  4ANJ A;  2X7C A;  1VFX A;  2KIN A;  3X2T A;  3U06 A;  3KAR A;  2VAS A;  2Q2Y A;  4ZHI A;  4HNA K;  3T0Q A;  2IEH A;  2WOG A;  3WPN A;  4A1Z A;  1VOM A;  4DBQ A;  5LT2 A;  1RY6 A;  1CZ7 A;  4BBG A;  2FME A;  1MNE A;  4E7S A;  1N6M A;  1VFV A;  2V26 A;  1BR4 A;  1KK7 A;  1MMD A;  2XAE A;  1D0X A;  4PJM A;  3COB A;  2MYS A;  2PG2 A;  4PFO A;  4UBF A;  4AS7 A;  2X7E A;  4DBR A;  2VVG A;  1F9W A;  1GOJ A;  3B6V A;  3H4S A;  2X51 A;  4A28 A;  4E7Z A;  1F9V A;  4A5Y A;  3PXN A;  1MKJ A;  2X7D A;  1I5S A;  2GM1 A;  4PJN A;  3K5E A;  3ZFD A;  1D1B A;  2UYM A;  1X88 A;  4AP0 A;  4BXN A;  1D1A A;  1D1C A;  1F9U A;  2FL6 A;  3L1C A;  2Y5W A;  3NWN A;  1MMG A;  4H1G A;  3L9H A;  2VB6 A;  4ZCA A;  4BN2 A;  3CNZ A;  2Q2Z A;  2UYI A;  4A50 A;  2G1Q A;  2ZFM A;  3DCB A;  1II6 A;  4A14 A;  1G8X A;  4ETP A;  1SDM A;  4PJJ A;  3ZFC A;  1V8K A;  5LT0 A;  4PJL A;  3CJO A;  2X2R A;  5LT1 A;  2Y65 A;  2ZFI A;  2GRY A;  4Y05 A;  2HEH A;  1BR2 A; 
#chains in the Genus database with same CATH topology
 2FKY A;  3ZCW A;  5LT4 A;  4FRZ A;  4GKR A;  4LNU K;  1BG2 A;  1I6I A;  1LKX A;  1Q0B A;  1D0Y A;  4B7B A;  1FMV A;  3B6U A;  2ZFL A;  4A51 A;  3LRE A;  1VFW A;  1BR1 A;  3KIN A;  3GBJ A;  3WRD A;  4ETP B;  1T5C A;  3DC4 A;  1YRS A;  3BFN A;  1FMW A;  1D0Z A;  4PK4 A;  1MMN A;  2OWM A;  3KEN A;  5HLE A;  1LVK A;  2FL2 A;  1VFZ A;  2NCD A;  2XT3 A;  1F9T A;  1V8J A;  4PFP A;  1MMA A;  5LT3 A;  2ZFJ A;  5GSZ A;  3K3B A;  3HQD A;  2ZFK A;  4ANJ A;  2X7C A;  2O0A A;  1VFX A;  2KIN A;  3X2T A;  3U06 A;  3KAR A;  2VAS A;  2Q2Y A;  4ZHI A;  4HNA K;  3T0Q A;  4GKP A;  2IEH A;  2WOG A;  3WPN A;  4A1Z A;  1VOM A;  4DBQ A;  4GKQ A;  5LT2 A;  1RY6 A;  1CZ7 A;  4BBG A;  2FME A;  1MNE A;  4E7S A;  1N6M A;  1VFV A;  2V26 A;  1BR4 A;  1KK7 A;  1MMD A;  2XAE A;  1D0X A;  4PJM A;  3COB A;  2MYS A;  2PG2 A;  4PFO A;  4UBF A;  4AS7 A;  2X7E A;  4DBR A;  2VVG A;  1F9W A;  1GOJ A;  3B6V A;  3H4S A;  2X51 A;  4A28 A;  4E7Z A;  1F9V A;  4A5Y A;  3PXN A;  1MKJ A;  2X7D A;  1I5S A;  2GM1 A;  4PJN A;  3K5E A;  3ZFD A;  1D1B A;  2UYM A;  1X88 A;  4AP0 A;  4BXN A;  1D1A A;  1D1C A;  1F9U A;  2FL6 A;  3L1C A;  2Y5W A;  3NWN A;  1MMG A;  4H1G A;  3L9H A;  2VB6 A;  4ZCA A;  4BN2 A;  3CNZ A;  2Q2Z A;  2UYI A;  4A50 A;  2G1Q A;  2ZFM A;  3DCB A;  1II6 A;  4A14 A;  1G8X A;  4ETP A;  1SDM A;  4PJJ A;  3ZFC A;  1V8K A;  5LT0 A;  4PJL A;  3CJO A;  2X2R A;  5LT1 A;  2Y65 A;  2ZFI A;  2GRY A;  4Y05 A;  2HEH A;  1BR2 A; 
#chains in the Genus database with same CATH homology
 2FKY A;  3ZCW A;  5LT4 A;  4FRZ A;  4GKR A;  4LNU K;  1BG2 A;  1I6I A;  1LKX A;  1Q0B A;  1D0Y A;  4B7B A;  1FMV A;  3B6U A;  2ZFL A;  4A51 A;  3LRE A;  1VFW A;  1BR1 A;  3KIN A;  3GBJ A;  3WRD A;  1T5C A;  3DC4 A;  1YRS A;  3BFN A;  1FMW A;  1D0Z A;  4PK4 A;  1MMN A;  2OWM A;  3KEN A;  5HLE A;  1LVK A;  2FL2 A;  1VFZ A;  2NCD A;  2XT3 A;  1F9T A;  1V8J A;  4PFP A;  1MMA A;  5LT3 A;  2ZFJ A;  5GSZ A;  3K3B A;  3HQD A;  2ZFK A;  4ANJ A;  2X7C A;  1VFX A;  2KIN A;  3X2T A;  3U06 A;  3KAR A;  2VAS A;  2Q2Y A;  4ZHI A;  4HNA K;  3T0Q A;  2IEH A;  2WOG A;  3WPN A;  4A1Z A;  1VOM A;  4DBQ A;  5LT2 A;  1RY6 A;  1CZ7 A;  4BBG A;  2FME A;  1MNE A;  4E7S A;  1N6M A;  1VFV A;  2V26 A;  1BR4 A;  1KK7 A;  1MMD A;  2XAE A;  1D0X A;  4PJM A;  3COB A;  2MYS A;  2PG2 A;  4PFO A;  4UBF A;  4AS7 A;  2X7E A;  4DBR A;  2VVG A;  1F9W A;  1GOJ A;  3B6V A;  3H4S A;  2X51 A;  4A28 A;  4E7Z A;  1F9V A;  4A5Y A;  3PXN A;  1MKJ A;  2X7D A;  1I5S A;  2GM1 A;  4PJN A;  3K5E A;  3ZFD A;  1D1B A;  2UYM A;  1X88 A;  4AP0 A;  4BXN A;  1D1A A;  1D1C A;  1F9U A;  2FL6 A;  3L1C A;  2Y5W A;  3NWN A;  1MMG A;  4H1G A;  3L9H A;  2VB6 A;  4ZCA A;  4BN2 A;  3CNZ A;  2Q2Z A;  2UYI A;  4A50 A;  2G1Q A;  2ZFM A;  3DCB A;  1II6 A;  4A14 A;  1G8X A;  4ETP A;  1SDM A;  4PJJ A;  3ZFC A;  1V8K A;  5LT0 A;  4PJL A;  3CJO A;  2X2R A;  5LT1 A;  2Y65 A;  2ZFI A;  2GRY A;  4Y05 A;  2HEH A;  1BR2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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