4HKKB

Complex structure of human tankyrase 2 with apigenin
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hkkB00
4L2FC 5ADSB 4KZQC 4HKNC 4L0SC 4HKIC 4L0IC 4HMHC 4UI5C 4UI6C 4HLFC 4UI3C 4L0VC 5FPFC 4KZUC 4HLGC 4L0BC 4HKKB 4L31C 4HL5C 4UI8C 4UVPB 4L0TC 4L2KC 5ADQB 4HLKC 4HLMC 4L32C 5C5QC 5ADTB 4UI7C 4UI4C 4KZLC 5C5RC 5C5PC 4L2GC 4L33C 4L09C 4HLHC 4L10C 5ADRB 4L34C
chains in the Genus database with same CATH superfamily
4L2FC 5ADSB 3OEIA 4KZQC 4HKNC 3K33B 4L0SC 4ZLXA 4HKIC 3CTOA 4ZM0A 4L0IC 4HMHC 4UI5C 4UI6C 4HLFC 4UI3C 4ZM2A 3HS2A 3G5OA 2ZIXB 3KH2E 4L0VC 5FPFC 3HRYA 4KZUC 3K6QA 4HLGC 4L0BC 4HKKB 4L31C 4HL5C 4UI8C 2ODKA 4UVPB 4L0TC 3OEIE 4L2KC 5ADQB 4HLKC 4HLMC 4L32C 5C5QC 5ADTB 4UI7C 4UI4C 3D55A 4KZLC 5C5RC 2A6QA 5C5PC 3HJ6A 4L2GC 4L33C 4L09C 4HLHC 4L10C 5ADRB 4L34C
chains in the Genus database with same CATH topology
4L2FC 5ADSB 4KZQC 4HKNC 4L0SC 4HKIC 4L0IC 4HMHC 4UI5C 4UI6C 4HLFC 4UI3C 2ZIXB 4L0VC 5FPFC 4KZUC 4HLGC 4L0BC 4HKKB 4L31C 4HL5C 4UI8C 4UVPB 4L0TC 4L2KC 5ADQB 4HLKC 4HLMC 4L32C 5C5QC 5ADTB 4UI7C 4UI4C 4KZLC 5C5RC 5C5PC 3HJ6A 4L2GC 4L33C 4L09C 4HLHC 4L10C 5ADRB 4L34C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L2F C;  5ADS B;  4KZQ C;  4HKN C;  4L0S C;  4HKI C;  4L0I C;  4HMH C;  4UI5 C;  4UI6 C;  4HLF C;  4UI3 C;  4L0V C;  5FPF C;  4KZU C;  4HLG C;  4L0B C;  4HKK B;  4L31 C;  4HL5 C;  4UI8 C;  4UVP B;  4L0T C;  4L2K C;  5ADQ B;  4HLK C;  4HLM C;  4L32 C;  5C5Q C;  5ADT B;  4UI7 C;  4UI4 C;  4KZL C;  5C5R C;  5C5P C;  4L2G C;  4L33 C;  4L09 C;  4HLH C;  4L10 C;  5ADR B;  4L34 C; 
#chains in the Genus database with same CATH topology
 4L2F C;  5ADS B;  3OEI A;  4KZQ C;  4HKN C;  3K33 B;  4L0S C;  4ZLX A;  4HKI C;  3CTO A;  4ZM0 A;  4L0I C;  4HMH C;  4UI5 C;  4UI6 C;  4HLF C;  4UI3 C;  4ZM2 A;  3HS2 A;  3G5O A;  2ZIX B;  3KH2 E;  4L0V C;  5FPF C;  3HRY A;  4KZU C;  3K6Q A;  4HLG C;  4L0B C;  4HKK B;  4L31 C;  4HL5 C;  4UI8 C;  2ODK A;  4UVP B;  4L0T C;  3OEI E;  4L2K C;  5ADQ B;  4HLK C;  4HLM C;  4L32 C;  5C5Q C;  5ADT B;  4UI7 C;  4UI4 C;  3D55 A;  4KZL C;  5C5R C;  2A6Q A;  5C5P C;  3HJ6 A;  4L2G C;  4L33 C;  4L09 C;  4HLH C;  4L10 C;  5ADR B;  4L34 C; 
#chains in the Genus database with same CATH homology
 4L2F C;  5ADS B;  4KZQ C;  4HKN C;  4L0S C;  4HKI C;  4L0I C;  4HMH C;  4UI5 C;  4UI6 C;  4HLF C;  4UI3 C;  2ZIX B;  4L0V C;  5FPF C;  4KZU C;  4HLG C;  4L0B C;  4HKK B;  4L31 C;  4HL5 C;  4UI8 C;  4UVP B;  4L0T C;  4L2K C;  5ADQ B;  4HLK C;  4HLM C;  4L32 C;  5C5Q C;  5ADT B;  4UI7 C;  4UI4 C;  4KZL C;  5C5R C;  5C5P C;  3HJ6 A;  4L2G C;  4L33 C;  4L09 C;  4HLH C;  4L10 C;  5ADR B;  4L34 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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