5ADQB

Crystal structure of human tankyrase 2 in complex with jw55
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords TANKYRASE-2
publication title Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 46
sequence length 46
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-08-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5adqB00
4HKNC 4UVPB 4UI7C 4L34C 4HL5C 4L09C 4L32C 4KZQC 4L31C 4KZLC 4UI4C 4HLFC 4L10C 4L0IC 4L2FC 4L0VC 4HLGC 5ADRB 4UI3C 4HKIC 4HKKB 4L0SC 5C5QC 4L33C 4HLMC 4UI8C 4UI6C 4HLKC 4UI5C 4L2KC 4L0TC 5FPFC 4HMHC 4L2GC 5ADTB 5ADQB 5C5PC 4KZUC 5C5RC 5ADSB 4L0BC 4HLHC
chains in the Genus database with same CATH superfamily
4HKNC 4UVPB 4UI7C 4L34C 2ZIXB 2A6QA 3CTOA 4ZM2A 4HL5C 4L09C 4L32C 4KZQC 3K33B 4L31C 4KZLC 3HRYA 4UI4C 3OEIE 4L0BC 3HS2A 3HJ6A 4HLFC 4L10C 4L0IC 4L2FC 4L0VC 4HLGC 5ADRB 4UI3C 4HKIC 4HKKB 4L0SC 5C5QC 3K6QA 4L33C 4HLMC 4UI8C 4ZLXA 3G5OA 4UI6C 2ODKA 4HLKC 4UI5C 4L2KC 4L0TC 5FPFC 4HMHC 4L2GC 3OEIA 5ADTB 5ADQB 5C5PC 4ZM0A 4KZUC 5C5RC 3KH2E 5ADSB 3D55A 4HLHC
chains in the Genus database with same CATH topology
4HKNC 4UVPB 4UI7C 4L34C 2ZIXB 4HL5C 4L09C 4L32C 4KZQC 4L31C 4KZLC 4UI4C 4HLFC 3HJ6A 4L10C 4L0IC 4L2FC 4L0VC 4HLGC 5ADRB 4UI3C 4HKIC 4HKKB 4L0SC 5C5QC 4L33C 4HLMC 4UI8C 4UI6C 4HLKC 4UI5C 4L2KC 4L0TC 5FPFC 4HMHC 4L2GC 5ADTB 5ADQB 5C5PC 4KZUC 5C5RC 5ADSB 4L0BC 4HLHC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HKN C;  4UVP B;  4UI7 C;  4L34 C;  4HL5 C;  4L09 C;  4L32 C;  4KZQ C;  4L31 C;  4KZL C;  4UI4 C;  4HLF C;  4L10 C;  4L0I C;  4L2F C;  4L0V C;  4HLG C;  5ADR B;  4UI3 C;  4HKI C;  4HKK B;  4L0S C;  5C5Q C;  4L33 C;  4HLM C;  4UI8 C;  4UI6 C;  4HLK C;  4UI5 C;  4L2K C;  4L0T C;  5FPF C;  4HMH C;  4L2G C;  5ADT B;  5ADQ B;  5C5P C;  4KZU C;  5C5R C;  5ADS B;  4L0B C;  4HLH C; 
#chains in the Genus database with same CATH topology
 4HKN C;  4UVP B;  4UI7 C;  4L34 C;  2ZIX B;  2A6Q A;  3CTO A;  4ZM2 A;  4HL5 C;  4L09 C;  4L32 C;  4KZQ C;  3K33 B;  4L31 C;  4KZL C;  3HRY A;  4UI4 C;  3OEI E;  4L0B C;  3HS2 A;  3HJ6 A;  4HLF C;  4L10 C;  4L0I C;  4L2F C;  4L0V C;  4HLG C;  5ADR B;  4UI3 C;  4HKI C;  4HKK B;  4L0S C;  5C5Q C;  3K6Q A;  4L33 C;  4HLM C;  4UI8 C;  4ZLX A;  3G5O A;  4UI6 C;  2ODK A;  4HLK C;  4UI5 C;  4L2K C;  4L0T C;  5FPF C;  4HMH C;  4L2G C;  3OEI A;  5ADT B;  5ADQ B;  5C5P C;  4ZM0 A;  4KZU C;  5C5R C;  3KH2 E;  5ADS B;  3D55 A;  4HLH C; 
#chains in the Genus database with same CATH homology
 4HKN C;  4UVP B;  4UI7 C;  4L34 C;  2ZIX B;  4HL5 C;  4L09 C;  4L32 C;  4KZQ C;  4L31 C;  4KZL C;  4UI4 C;  4HLF C;  3HJ6 A;  4L10 C;  4L0I C;  4L2F C;  4L0V C;  4HLG C;  5ADR B;  4UI3 C;  4HKI C;  4HKK B;  4L0S C;  5C5Q C;  4L33 C;  4HLM C;  4UI8 C;  4UI6 C;  4HLK C;  4UI5 C;  4L2K C;  4L0T C;  5FPF C;  4HMH C;  4L2G C;  5ADT B;  5ADQ B;  5C5P C;  4KZU C;  5C5R C;  5ADS B;  4L0B C;  4HLH C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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