4HLFC

Crystal structure of tankyrase 2 in complex with 7,3',4'-trihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlfC00
5ADSB 4L2KC 4HKIC 4UI8C 4L2GC 4HL5C 4HKKB 4L09C 4L34C 4UVPB 4L0VC 5ADQB 4L32C 4KZQC 4L2FC 5C5RC 4L0TC 5FPFC 4L0SC 5C5QC 4HLHC 4HLFC 4HKNC 4HMHC 4L0IC 4KZLC 4L33C 4L0BC 5ADTB 4UI3C 4HLMC 4UI7C 4L31C 4HLKC 5C5PC 4L10C 5ADRB 4UI6C 4KZUC 4UI5C 4UI4C 4HLGC
chains in the Genus database with same CATH superfamily
5ADSB 2ODKA 4L2KC 4HKIC 4ZM0A 2A6QA 3HS2A 4L2GC 3CTOA 4HL5C 4HKKB 4L09C 4L34C 4UI8C 4UVPB 4ZLXA 3HJ6A 4L0VC 5ADQB 4L32C 4KZQC 4L2FC 5C5RC 3OEIA 4L0TC 5FPFC 4L0SC 3K33B 3KH2E 5C5QC 4HLHC 4HLFC 4HKNC 4HMHC 3D55A 4L0IC 4KZLC 4ZM2A 4L33C 4L0BC 5ADTB 4UI3C 3HRYA 4HLMC 4UI7C 4L31C 3K6QA 4HLKC 5C5PC 4L10C 5ADRB 4UI6C 3G5OA 3OEIE 2ZIXB 4KZUC 4UI5C 4UI4C 4HLGC
chains in the Genus database with same CATH topology
5ADSB 4L2KC 4HKIC 4UI8C 4L2GC 4HL5C 4HKKB 4L09C 4L34C 4UVPB 3HJ6A 4L0VC 5ADQB 4L32C 4KZQC 4L2FC 5C5RC 4L0TC 5FPFC 4L0SC 5C5QC 4HLHC 4HLFC 4HKNC 4HMHC 4L0IC 4KZLC 4L33C 4L0BC 5ADTB 4UI3C 4HLMC 4UI7C 4L31C 4HLKC 5C5PC 4L10C 5ADRB 4UI6C 2ZIXB 4KZUC 4UI5C 4UI4C 4HLGC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ADS B;  4L2K C;  4HKI C;  4UI8 C;  4L2G C;  4HL5 C;  4HKK B;  4L09 C;  4L34 C;  4UVP B;  4L0V C;  5ADQ B;  4L32 C;  4KZQ C;  4L2F C;  5C5R C;  4L0T C;  5FPF C;  4L0S C;  5C5Q C;  4HLH C;  4HLF C;  4HKN C;  4HMH C;  4L0I C;  4KZL C;  4L33 C;  4L0B C;  5ADT B;  4UI3 C;  4HLM C;  4UI7 C;  4L31 C;  4HLK C;  5C5P C;  4L10 C;  5ADR B;  4UI6 C;  4KZU C;  4UI5 C;  4UI4 C;  4HLG C; 
#chains in the Genus database with same CATH topology
 5ADS B;  2ODK A;  4L2K C;  4HKI C;  4ZM0 A;  2A6Q A;  3HS2 A;  4L2G C;  3CTO A;  4HL5 C;  4HKK B;  4L09 C;  4L34 C;  4UI8 C;  4UVP B;  4ZLX A;  3HJ6 A;  4L0V C;  5ADQ B;  4L32 C;  4KZQ C;  4L2F C;  5C5R C;  3OEI A;  4L0T C;  5FPF C;  4L0S C;  3K33 B;  3KH2 E;  5C5Q C;  4HLH C;  4HLF C;  4HKN C;  4HMH C;  3D55 A;  4L0I C;  4KZL C;  4ZM2 A;  4L33 C;  4L0B C;  5ADT B;  4UI3 C;  3HRY A;  4HLM C;  4UI7 C;  4L31 C;  3K6Q A;  4HLK C;  5C5P C;  4L10 C;  5ADR B;  4UI6 C;  3G5O A;  3OEI E;  2ZIX B;  4KZU C;  4UI5 C;  4UI4 C;  4HLG C; 
#chains in the Genus database with same CATH homology
 5ADS B;  4L2K C;  4HKI C;  4UI8 C;  4L2G C;  4HL5 C;  4HKK B;  4L09 C;  4L34 C;  4UVP B;  3HJ6 A;  4L0V C;  5ADQ B;  4L32 C;  4KZQ C;  4L2F C;  5C5R C;  4L0T C;  5FPF C;  4L0S C;  5C5Q C;  4HLH C;  4HLF C;  4HKN C;  4HMH C;  4L0I C;  4KZL C;  4L33 C;  4L0B C;  5ADT B;  4UI3 C;  4HLM C;  4UI7 C;  4L31 C;  4HLK C;  5C5P C;  4L10 C;  5ADR B;  4UI6 C;  2ZIX B;  4KZU C;  4UI5 C;  4UI4 C;  4HLG C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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