4HLKC

Crystal structure of tankyrase 2 in complex with 4'-methylflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlkC00
4L31C 4L2KC 4HLHC 4UI4C 5C5PC 4L0SC 4L32C 4UI3C 4L0IC 4KZQC 4L2FC 4KZUC 5C5RC 5ADRB 4L0TC 4UVPB 4HKKB 4UI6C 5ADSB 5FPFC 4L10C 4UI5C 4UI7C 5ADTB 4KZLC 4L34C 4L09C 4HLMC 4L0BC 4L0VC 4HL5C 4HKIC 5C5QC 4HKNC 4L33C 4HLFC 4HMHC 5ADQB 4HLKC 4L2GC 4UI8C 4HLGC
chains in the Genus database with same CATH superfamily
4L31C 2ODKA 3KH2E 4L2KC 4HLHC 4UI4C 2A6QA 5C5PC 4L0SC 4L32C 4UI3C 4L0IC 4KZQC 4L2FC 3HJ6A 3K6QA 3HRYA 4KZUC 3OEIA 5C5RC 5ADRB 4L0TC 4UVPB 4HKKB 2ZIXB 3D55A 4UI6C 5FPFC 5ADSB 4L10C 4UI5C 4UI7C 5ADTB 4KZLC 4L34C 3OEIE 4L09C 4HLMC 3HS2A 4ZLXA 4ZM2A 4L0BC 4HL5C 4L0VC 4HKIC 5C5QC 4HKNC 4L33C 4HLFC 3G5OA 3CTOA 4HMHC 5ADQB 4HLKC 4L2GC 4ZM0A 3K33B 4UI8C 4HLGC
chains in the Genus database with same CATH topology
4L31C 4L2KC 4HLHC 4UI4C 5C5PC 4L0SC 4L32C 4UI3C 4L0IC 4KZQC 4L2FC 3HJ6A 4KZUC 5C5RC 5ADRB 4L0TC 4UVPB 4HKKB 2ZIXB 4UI6C 5ADSB 5FPFC 4L10C 4UI5C 4UI7C 5ADTB 4KZLC 4L34C 4L09C 4HLMC 4L0BC 4HL5C 4L0VC 4HKIC 5C5QC 4HKNC 4L33C 4HLFC 4HMHC 5ADQB 4HLKC 4L2GC 4UI8C 4HLGC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L31 C;  4L2K C;  4HLH C;  4UI4 C;  5C5P C;  4L0S C;  4L32 C;  4UI3 C;  4L0I C;  4KZQ C;  4L2F C;  4KZU C;  5C5R C;  5ADR B;  4L0T C;  4UVP B;  4HKK B;  4UI6 C;  5ADS B;  5FPF C;  4L10 C;  4UI5 C;  4UI7 C;  5ADT B;  4KZL C;  4L34 C;  4L09 C;  4HLM C;  4L0B C;  4L0V C;  4HL5 C;  4HKI C;  5C5Q C;  4HKN C;  4L33 C;  4HLF C;  4HMH C;  5ADQ B;  4HLK C;  4L2G C;  4UI8 C;  4HLG C; 
#chains in the Genus database with same CATH topology
 4L31 C;  2ODK A;  3KH2 E;  4L2K C;  4HLH C;  4UI4 C;  2A6Q A;  5C5P C;  4L0S C;  4L32 C;  4UI3 C;  4L0I C;  4KZQ C;  4L2F C;  3HJ6 A;  3K6Q A;  3HRY A;  4KZU C;  3OEI A;  5C5R C;  5ADR B;  4L0T C;  4UVP B;  4HKK B;  2ZIX B;  3D55 A;  4UI6 C;  5FPF C;  5ADS B;  4L10 C;  4UI5 C;  4UI7 C;  5ADT B;  4KZL C;  4L34 C;  3OEI E;  4L09 C;  4HLM C;  3HS2 A;  4ZLX A;  4ZM2 A;  4L0B C;  4HL5 C;  4L0V C;  4HKI C;  5C5Q C;  4HKN C;  4L33 C;  4HLF C;  3G5O A;  3CTO A;  4HMH C;  5ADQ B;  4HLK C;  4L2G C;  4ZM0 A;  3K33 B;  4UI8 C;  4HLG C; 
#chains in the Genus database with same CATH homology
 4L31 C;  4L2K C;  4HLH C;  4UI4 C;  5C5P C;  4L0S C;  4L32 C;  4UI3 C;  4L0I C;  4KZQ C;  4L2F C;  3HJ6 A;  4KZU C;  5C5R C;  5ADR B;  4L0T C;  4UVP B;  4HKK B;  2ZIX B;  4UI6 C;  5ADS B;  5FPF C;  4L10 C;  4UI5 C;  4UI7 C;  5ADT B;  4KZL C;  4L34 C;  4L09 C;  4HLM C;  4L0B C;  4HL5 C;  4L0V C;  4HKI C;  5C5Q C;  4HKN C;  4L33 C;  4HLF C;  4HMH C;  5ADQ B;  4HLK C;  4L2G C;  4UI8 C;  4HLG C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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