4HMHC

Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hmhC00
5C5RC 4HKIC 5C5PC 4L2GC 4HLGC 4HKKB 5ADSB 4UI7C 4UI8C 4L32C 4KZUC 4UI6C 4L0VC 4L2FC 4HLMC 4L0BC 4UI5C 4L2KC 5ADRB 4UVPB 4L0TC 4L34C 4L09C 4L0IC 4HLKC 4HLHC 4L31C 4L0SC 4HL5C 4HKNC 5C5QC 4L33C 4HLFC 5ADQB 5FPFC 4L10C 4KZQC 4HMHC 4UI4C 4UI3C 5ADTB 4KZLC
chains in the Genus database with same CATH superfamily
2ODKA 5C5RC 4HKIC 5C5PC 3HJ6A 3HS2A 4L2GC 4HLGC 4HKKB 5ADSB 4UI7C 4UI8C 4L32C 3HRYA 4KZUC 3G5OA 3K6QA 4UI6C 4L0VC 4L2FC 4HLMC 4L0BC 4UI5C 4L2KC 5ADRB 4UVPB 4ZLXA 4L0TC 4L34C 4L09C 4L0IC 4HLKC 2A6QA 4HLHC 4L31C 4L0SC 2ZIXB 3OEIE 4HL5C 4HKNC 5C5QC 3KH2E 4L33C 4ZM2A 4HLFC 5ADQB 5FPFC 4L10C 3K33B 4HMHC 4KZQC 4UI4C 3OEIA 4ZM0A 3CTOA 4UI3C 3D55A 5ADTB 4KZLC
chains in the Genus database with same CATH topology
5C5RC 4HKIC 5C5PC 3HJ6A 4L2GC 4HLGC 4HKKB 5ADSB 4UI7C 4UI8C 4L32C 4KZUC 4UI6C 4L0VC 4L2FC 4HLMC 4L0BC 4UI5C 4L2KC 5ADRB 4UVPB 4L0TC 4L34C 4L09C 4L0IC 4HLKC 4HLHC 4L31C 4L0SC 2ZIXB 4HL5C 4HKNC 5C5QC 4L33C 4HLFC 5ADQB 5FPFC 4L10C 4KZQC 4HMHC 4UI4C 4UI3C 5ADTB 4KZLC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C5R C;  4HKI C;  5C5P C;  4L2G C;  4HLG C;  4HKK B;  5ADS B;  4UI7 C;  4UI8 C;  4L32 C;  4KZU C;  4UI6 C;  4L0V C;  4L2F C;  4HLM C;  4L0B C;  4UI5 C;  4L2K C;  5ADR B;  4UVP B;  4L0T C;  4L34 C;  4L09 C;  4L0I C;  4HLK C;  4HLH C;  4L31 C;  4L0S C;  4HL5 C;  4HKN C;  5C5Q C;  4L33 C;  4HLF C;  5ADQ B;  5FPF C;  4L10 C;  4KZQ C;  4HMH C;  4UI4 C;  4UI3 C;  5ADT B;  4KZL C; 
#chains in the Genus database with same CATH topology
 2ODK A;  5C5R C;  4HKI C;  5C5P C;  3HJ6 A;  3HS2 A;  4L2G C;  4HLG C;  4HKK B;  5ADS B;  4UI7 C;  4UI8 C;  4L32 C;  3HRY A;  4KZU C;  3G5O A;  3K6Q A;  4UI6 C;  4L0V C;  4L2F C;  4HLM C;  4L0B C;  4UI5 C;  4L2K C;  5ADR B;  4UVP B;  4ZLX A;  4L0T C;  4L34 C;  4L09 C;  4L0I C;  4HLK C;  2A6Q A;  4HLH C;  4L31 C;  4L0S C;  2ZIX B;  3OEI E;  4HL5 C;  4HKN C;  5C5Q C;  3KH2 E;  4L33 C;  4ZM2 A;  4HLF C;  5ADQ B;  5FPF C;  4L10 C;  3K33 B;  4HMH C;  4KZQ C;  4UI4 C;  3OEI A;  4ZM0 A;  3CTO A;  4UI3 C;  3D55 A;  5ADT B;  4KZL C; 
#chains in the Genus database with same CATH homology
 5C5R C;  4HKI C;  5C5P C;  3HJ6 A;  4L2G C;  4HLG C;  4HKK B;  5ADS B;  4UI7 C;  4UI8 C;  4L32 C;  4KZU C;  4UI6 C;  4L0V C;  4L2F C;  4HLM C;  4L0B C;  4UI5 C;  4L2K C;  5ADR B;  4UVP B;  4L0T C;  4L34 C;  4L09 C;  4L0I C;  4HLK C;  4HLH C;  4L31 C;  4L0S C;  2ZIX B;  4HL5 C;  4HKN C;  5C5Q C;  4L33 C;  4HLF C;  5ADQ B;  5FPF C;  4L10 C;  4KZQ C;  4HMH C;  4UI4 C;  4UI3 C;  5ADT B;  4KZL C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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