1OW1A

Crystal structure of the spoc domain of the human transcriptional corepressor, sharp.
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
170
structure length
167
Chain Sequence
PVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPLSPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIVIASV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords SMART/HDAC1 associated repressor protein
total genus 43
structure length 167
sequence length 170
ec nomenclature
pdb deposition date 2003-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07744 SPOC SPOC domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.290.10 Mainly Beta Beta Barrel Ku70; Chain: A; Domain 2 Ku70; Chain: A; Domain 2 1ow1A00
2RT5A 1JEYB 1JEYA 1JEQB 1OW1A 1JEQA
chains in the Genus database with same CATH superfamily
2RT5A 1JEYB 2KY6A 2L23A 1JEYA 1JEQB 1OW1A 3TIXB 2L6UA 2XNFA 1JEQA
chains in the Genus database with same CATH topology
2RT5A 1JEYB 2KY6A 2L23A 1JEYA 1JEQB 1OW1A 3TIXB 2L6UA 2XNFA 1JEQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RT5 A;  1JEY B;  1JEY A;  1JEQ B;  1OW1 A;  1JEQ A; 
#chains in the Genus database with same CATH topology
 2RT5 A;  1JEY B;  2KY6 A;  2L23 A;  1JEY A;  1JEQ B;  1OW1 A;  3TIX B;  2L6U A;  2XNF A;  1JEQ A; 
#chains in the Genus database with same CATH homology
 2RT5 A;  1JEY B;  2KY6 A;  2L23 A;  1JEY A;  1JEQ B;  1OW1 A;  3TIX B;  2L6U A;  2XNF A;  1JEQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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