1R4FA

Inosine-adenosine-guanosine preferring nucleoside hydrolase from trypanosoma vivax: trp260ala mutant in complex with 3-deaza-adenosine
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
327
structure length
314
Chain Sequence
SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYAADALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Leaving group activation by aromatic stacking: an alternative to general Acid catalysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma vivax
molecule keywords IAG-nucleoside hydrolase
total genus 110
structure length 314
sequence length 327
chains with identical sequence B
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2003-10-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 1r4fA00
2FF1A 1KIEA 3EPXA 1EZRA 3MKMA 4I75A 1MASA 4I70A 2YHGA 3B9XA 1KICA 2C40A 4I71A 4I74A 3EPWA 1Q8FA 1YOEA 4KPOA 2FF2A 1R4FA 4I73A 3B9GA 5TSQA 3T8IA 1HOZA 2MASA 3FZ0A 4KPNA 4I72A 3T8JA 3G5IA 1HP0A 4KL0A 4WR2A 3MKNA 4P5FA
chains in the Genus database with same CATH superfamily
2FF1A 1KIEA 3EPXA 1EZRA 3MKMA 4I75A 1MASA 4I70A 2YHGA 3B9XA 1KICA 2C40A 4I71A 4I74A 3EPWA 1Q8FA 1YOEA 4KPOA 2FF2A 1R4FA 4I73A 3B9GA 5TSQA 3T8IA 1HOZA 2MASA 3FZ0A 4KPNA 4I72A 3T8JA 3G5IA 1HP0A 4KL0A 4WR2A 3MKNA 4P5FA
chains in the Genus database with same CATH topology
2FF1A 1KIEA 3EPXA 1EZRA 3MKMA 4I75A 1MASA 4I70A 2YHGA 3B9XA 1KICA 2C40A 4I71A 4I74A 3EPWA 1Q8FA 1YOEA 4KPOA 2FF2A 1R4FA 4I73A 3B9GA 5TSQA 3T8IA 1HOZA 2MASA 3FZ0A 4KPNA 4I72A 3T8JA 3G5IA 1HP0A 4KL0A 4WR2A 3MKNA 4P5FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FF1 A;  1KIE A;  3EPX A;  1EZR A;  3MKM A;  4I75 A;  1MAS A;  4I70 A;  2YHG A;  3B9X A;  1KIC A;  2C40 A;  4I71 A;  4I74 A;  3EPW A;  1Q8F A;  1YOE A;  4KPO A;  2FF2 A;  1R4F A;  4I73 A;  3B9G A;  5TSQ A;  3T8I A;  1HOZ A;  2MAS A;  3FZ0 A;  4KPN A;  4I72 A;  3T8J A;  3G5I A;  1HP0 A;  4KL0 A;  4WR2 A;  3MKN A;  4P5F A; 
#chains in the Genus database with same CATH topology
 2FF1 A;  1KIE A;  3EPX A;  1EZR A;  3MKM A;  4I75 A;  1MAS A;  4I70 A;  2YHG A;  3B9X A;  1KIC A;  2C40 A;  4I71 A;  4I74 A;  3EPW A;  1Q8F A;  1YOE A;  4KPO A;  2FF2 A;  1R4F A;  4I73 A;  3B9G A;  5TSQ A;  3T8I A;  1HOZ A;  2MAS A;  3FZ0 A;  4KPN A;  4I72 A;  3T8J A;  3G5I A;  1HP0 A;  4KL0 A;  4WR2 A;  3MKN A;  4P5F A; 
#chains in the Genus database with same CATH homology
 2FF1 A;  1KIE A;  3EPX A;  1EZR A;  3MKM A;  4I75 A;  1MAS A;  4I70 A;  2YHG A;  3B9X A;  1KIC A;  2C40 A;  4I71 A;  4I74 A;  3EPW A;  1Q8F A;  1YOE A;  4KPO A;  2FF2 A;  1R4F A;  4I73 A;  3B9G A;  5TSQ A;  3T8I A;  1HOZ A;  2MAS A;  3FZ0 A;  4KPN A;  4I72 A;  3T8J A;  3G5I A;  1HP0 A;  4KL0 A;  4WR2 A;  3MKN A;  4P5F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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