2L23A

Nmr structure of the acid (activator interacting domain) of the human mediator med25 protein
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
161
structure length
161
Chain Sequence
MGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR structure of the human Mediator MED25 ACID domain.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Mediator of RNA polymerase II transcription subunit 25
total genus 24
structure length 161
sequence length 161
ec nomenclature
pdb deposition date 2010-08-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF11232 Med25 Mediator complex subunit 25 PTOV activation and synapsin 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.290.30 Mainly Beta Beta Barrel Ku70; Chain: A; Domain 2 Ku70; Chain: A; Domain 2 2l23A00
2L6UA 2XNFA 2KY6A 2L23A
chains in the Genus database with same CATH superfamily
2XNFA 2RT5A 1JEYB 3TIXB 2L6UA 1JEYA 1OW1A 1JEQB 1JEQA 2KY6A 2L23A
chains in the Genus database with same CATH topology
2XNFA 2RT5A 1JEYB 3TIXB 2L6UA 1JEYA 1OW1A 1JEQB 1JEQA 2KY6A 2L23A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L6U A;  2XNF A;  2KY6 A;  2L23 A; 
#chains in the Genus database with same CATH topology
 2XNF A;  2RT5 A;  1JEY B;  3TIX B;  2L6U A;  1JEY A;  1OW1 A;  1JEQ B;  1JEQ A;  2KY6 A;  2L23 A; 
#chains in the Genus database with same CATH homology
 2XNF A;  2RT5 A;  1JEY B;  3TIX B;  2L6U A;  1JEY A;  1OW1 A;  1JEQ B;  1JEQ A;  2KY6 A;  2L23 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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