2XNFA

The mediator med25 activator interaction domain: structure and cooperative binding of vp16 subdomains
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
159
structure length
159
Chain Sequence
MSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNLEHHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and Vp16 Binding of the Mediator Med25 Activator Interaction Domain.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25
total genus 36
structure length 159
sequence length 159
ec nomenclature
pdb deposition date 2010-08-02
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.290.30 Mainly Beta Beta Barrel Ku70; Chain: A; Domain 2 Ku70; Chain: A; Domain 2 2xnfA00
2XNFA 2L23A 2L6UA 2KY6A
chains in the Genus database with same CATH superfamily
1OW1A 2XNFA 1JEQB 2RT5A 1JEQA 3TIXB 2L23A 1JEYB 1JEYA 2L6UA 2KY6A
chains in the Genus database with same CATH topology
1OW1A 2XNFA 1JEQB 2RT5A 1JEQA 3TIXB 2L23A 1JEYB 1JEYA 2L6UA 2KY6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XNF A;  2L23 A;  2L6U A;  2KY6 A; 
#chains in the Genus database with same CATH topology
 1OW1 A;  2XNF A;  1JEQ B;  2RT5 A;  1JEQ A;  3TIX B;  2L23 A;  1JEY B;  1JEY A;  2L6U A;  2KY6 A; 
#chains in the Genus database with same CATH homology
 1OW1 A;  2XNF A;  1JEQ B;  2RT5 A;  1JEQ A;  3TIX B;  2L23 A;  1JEY B;  1JEY A;  2L6U A;  2KY6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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