3EPWA

Crystal structure of trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2r,3r,4s)-1-[(4-hydroxy-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
Total Genus 114

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
326
structure length
326
Chain Sequence
AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI1 (25-28)S1 (3-9)TVIII2 (128-131)AH2 (43-61)AH1 (13-24)TIV1 (38-41)TIV3 (253-256)AH13 (260-269)S4 (132-136)S2 (29-36)AH6 (140-156)AH3 (81-92)S3 (68-70)3H1 (94-96)AH5 (117-127)S5 (158-164)AH7 (185-189)S8 (293-296)TI3 (167-170)TI4 (176-179)TI7 (288-291)AH8 (191-199)S7 (274-284)TII1 (200-203)AH9 (210-214)TIV2 (214-217)AH10 (220-227)AH14 (313-324)TI5 (227-230)TI6 (229-232)AH11 (233-244)AH12 (247-251)3H2 (271-273)S9 (304-311)TII4 (299-302)TII3 (290-293)O1 (286-288)O2 (311-313)TVIII1 (75-78)S6 (205-208)TII2 (252-255)AH4 (99-114)Updating...
connected with : NaN
publication title Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
pubmed doi rcsb
molecule keywords IAG-nucleoside hydrolase
molecule tags Hydrolase
source organism Trypanosoma vivax
total genus 114
structure length 326
sequence length 326
chains with identical sequence B
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 3epwA00
3EPWA 4I73A 3FZ0A 4I72A 1KIEA 4KL0A 3T8JA 3EPXA 1KICA 3B9XA 2MASA 2FF1A 1MASA 4P5FA 4KPOA 3MKMA 5TSQA 3T8IA 1Q8FA 4KPNA 1EZRA 2FF2A 2YHGA 3MKNA 4I75A 4WR2A 1HOZA 4I74A 3B9GA 3G5IA 4I70A 4I71A 1HP0A 2C40A 1YOEA 1R4FA
chains in the Genus database with same CATH superfamily
3EPWA 4I73A 3FZ0A 4I72A 1KIEA 4KL0A 3T8JA 3EPXA 1KICA 3B9XA 2MASA 2FF1A 1MASA 4P5FA 4KPOA 3MKMA 5TSQA 3T8IA 1Q8FA 4KPNA 1EZRA 2FF2A 2YHGA 3MKNA 4I75A 4WR2A 1HOZA 4I74A 3B9GA 3G5IA 4I70A 4I71A 1HP0A 2C40A 1YOEA 1R4FA
chains in the Genus database with same CATH topology
3EPWA 4I73A 3FZ0A 4I72A 1KIEA 4KL0A 3T8JA 3EPXA 1KICA 3B9XA 2MASA 2FF1A 1MASA 4P5FA 4KPOA 3MKMA 5TSQA 3T8IA 1Q8FA 4KPNA 1EZRA 2FF2A 2YHGA 3MKNA 4I75A 4WR2A 1HOZA 4I74A 3B9GA 3G5IA 4I70A 4I71A 1HP0A 2C40A 1YOEA 1R4FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EPW A;  4I73 A;  3FZ0 A;  4I72 A;  1KIE A;  4KL0 A;  3T8J A;  3EPX A;  1KIC A;  3B9X A;  2MAS A;  2FF1 A;  1MAS A;  4P5F A;  4KPO A;  3MKM A;  5TSQ A;  3T8I A;  1Q8F A;  4KPN A;  1EZR A;  2FF2 A;  2YHG A;  3MKN A;  4I75 A;  4WR2 A;  1HOZ A;  4I74 A;  3B9G A;  3G5I A;  4I70 A;  4I71 A;  1HP0 A;  2C40 A;  1YOE A;  1R4F A; 
#chains in the Genus database with same CATH topology
 3EPW A;  4I73 A;  3FZ0 A;  4I72 A;  1KIE A;  4KL0 A;  3T8J A;  3EPX A;  1KIC A;  3B9X A;  2MAS A;  2FF1 A;  1MAS A;  4P5F A;  4KPO A;  3MKM A;  5TSQ A;  3T8I A;  1Q8F A;  4KPN A;  1EZR A;  2FF2 A;  2YHG A;  3MKN A;  4I75 A;  4WR2 A;  1HOZ A;  4I74 A;  3B9G A;  3G5I A;  4I70 A;  4I71 A;  1HP0 A;  2C40 A;  1YOE A;  1R4F A; 
#chains in the Genus database with same CATH homology
 3EPW A;  4I73 A;  3FZ0 A;  4I72 A;  1KIE A;  4KL0 A;  3T8J A;  3EPX A;  1KIC A;  3B9X A;  2MAS A;  2FF1 A;  1MAS A;  4P5F A;  4KPO A;  3MKM A;  5TSQ A;  3T8I A;  1Q8F A;  4KPN A;  1EZR A;  2FF2 A;  2YHG A;  3MKN A;  4I75 A;  4WR2 A;  1HOZ A;  4I74 A;  3B9G A;  3G5I A;  4I70 A;  4I71 A;  1HP0 A;  2C40 A;  1YOE A;  1R4F A; 
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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