3EPXA

Crystal structure of trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2r,3r,4s)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
326
structure length
322
Chain Sequence
AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCEGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma vivax
molecule keywords IAG-nucleoside hydrolase
total genus 119
structure length 322
sequence length 326
chains with identical sequence B
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 3epxA00
4WR2A 4KL0A 1HOZA 1KIEA 2MASA 2YHGA 2FF2A 1YOEA 3G5IA 4I70A 3EPWA 4I72A 3FZ0A 4P5FA 3B9GA 1KICA 1MASA 1Q8FA 3T8JA 3B9XA 4I71A 1EZRA 2FF1A 3MKNA 4KPNA 1HP0A 2C40A 4I75A 4I73A 3EPXA 5TSQA 3T8IA 1R4FA 4I74A 3MKMA 4KPOA
chains in the Genus database with same CATH superfamily
4WR2A 4KL0A 1HOZA 1KIEA 2MASA 2YHGA 2FF2A 1YOEA 3G5IA 4I70A 3EPWA 4I72A 3FZ0A 4P5FA 3B9GA 1KICA 1MASA 1Q8FA 3T8JA 3B9XA 4I71A 1EZRA 2FF1A 3MKNA 4KPNA 1HP0A 2C40A 4I75A 4I73A 3EPXA 5TSQA 3T8IA 1R4FA 4I74A 3MKMA 4KPOA
chains in the Genus database with same CATH topology
4WR2A 4KL0A 1HOZA 1KIEA 2MASA 2YHGA 2FF2A 1YOEA 3G5IA 4I70A 3EPWA 4I72A 3FZ0A 4P5FA 3B9GA 1KICA 1MASA 1Q8FA 3T8JA 3B9XA 4I71A 1EZRA 2FF1A 3MKNA 4KPNA 1HP0A 2C40A 4I75A 4I73A 3EPXA 5TSQA 3T8IA 1R4FA 4I74A 3MKMA 4KPOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WR2 A;  4KL0 A;  1HOZ A;  1KIE A;  2MAS A;  2YHG A;  2FF2 A;  1YOE A;  3G5I A;  4I70 A;  3EPW A;  4I72 A;  3FZ0 A;  4P5F A;  3B9G A;  1KIC A;  1MAS A;  1Q8F A;  3T8J A;  3B9X A;  4I71 A;  1EZR A;  2FF1 A;  3MKN A;  4KPN A;  1HP0 A;  2C40 A;  4I75 A;  4I73 A;  3EPX A;  5TSQ A;  3T8I A;  1R4F A;  4I74 A;  3MKM A;  4KPO A; 
#chains in the Genus database with same CATH topology
 4WR2 A;  4KL0 A;  1HOZ A;  1KIE A;  2MAS A;  2YHG A;  2FF2 A;  1YOE A;  3G5I A;  4I70 A;  3EPW A;  4I72 A;  3FZ0 A;  4P5F A;  3B9G A;  1KIC A;  1MAS A;  1Q8F A;  3T8J A;  3B9X A;  4I71 A;  1EZR A;  2FF1 A;  3MKN A;  4KPN A;  1HP0 A;  2C40 A;  4I75 A;  4I73 A;  3EPX A;  5TSQ A;  3T8I A;  1R4F A;  4I74 A;  3MKM A;  4KPO A; 
#chains in the Genus database with same CATH homology
 4WR2 A;  4KL0 A;  1HOZ A;  1KIE A;  2MAS A;  2YHG A;  2FF2 A;  1YOE A;  3G5I A;  4I70 A;  3EPW A;  4I72 A;  3FZ0 A;  4P5F A;  3B9G A;  1KIC A;  1MAS A;  1Q8F A;  3T8J A;  3B9X A;  4I71 A;  1EZR A;  2FF1 A;  3MKN A;  4KPN A;  1HP0 A;  2C40 A;  4I75 A;  4I73 A;  3EPX A;  5TSQ A;  3T8I A;  1R4F A;  4I74 A;  3MKM A;  4KPO A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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