3MKNA

Crystal structure of the e. coli pyrimidine nucleosidase yeik bound to a competitive inhibitor
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
310
structure length
303
Chain Sequence
KRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGDTGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFEPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Energy Landscapes Associated with Macromolecular Conformational Changes from Endpoint Structures
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Escherichia coli
molecule keywords Putative uncharacterized protein YeiK
total genus 108
structure length 303
sequence length 310
chains with identical sequence B, C, D
ec nomenclature ec 3.2.2.8: Ribosylpyrimidine nucleosidase.
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 3mknA00
3T8IA 2FF1A 1HOZA 3B9GA 3MKMA 1MASA 4I70A 4KL0A 1HP0A 3MKNA 2YHGA 1KICA 1Q8FA 2FF2A 3B9XA 4I74A 4I72A 3FZ0A 1R4FA 2MASA 3G5IA 4I71A 5TSQA 2C40A 3EPWA 1EZRA 1YOEA 4I73A 4KPNA 3EPXA 4I75A 4KPOA 1KIEA 4P5FA 3T8JA 4WR2A
chains in the Genus database with same CATH superfamily
3T8IA 2FF1A 1HOZA 3B9GA 3MKMA 1MASA 4I70A 4KL0A 1HP0A 3MKNA 2YHGA 1KICA 1Q8FA 2FF2A 3B9XA 4I74A 4I72A 3FZ0A 1R4FA 2MASA 3G5IA 4I71A 5TSQA 2C40A 3EPWA 1EZRA 1YOEA 4I73A 4KPNA 3EPXA 4I75A 4KPOA 1KIEA 4P5FA 3T8JA 4WR2A
chains in the Genus database with same CATH topology
3T8IA 2FF1A 1HOZA 3B9GA 3MKMA 1MASA 4I70A 4KL0A 1HP0A 3MKNA 2YHGA 1KICA 1Q8FA 2FF2A 3B9XA 4I74A 4I72A 3FZ0A 1R4FA 2MASA 3G5IA 4I71A 5TSQA 2C40A 3EPWA 1EZRA 1YOEA 4I73A 4KPNA 3EPXA 4I75A 4KPOA 1KIEA 4P5FA 3T8JA 4WR2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T8I A;  2FF1 A;  1HOZ A;  3B9G A;  3MKM A;  1MAS A;  4I70 A;  4KL0 A;  1HP0 A;  3MKN A;  2YHG A;  1KIC A;  1Q8F A;  2FF2 A;  3B9X A;  4I74 A;  4I72 A;  3FZ0 A;  1R4F A;  2MAS A;  3G5I A;  4I71 A;  5TSQ A;  2C40 A;  3EPW A;  1EZR A;  1YOE A;  4I73 A;  4KPN A;  3EPX A;  4I75 A;  4KPO A;  1KIE A;  4P5F A;  3T8J A;  4WR2 A; 
#chains in the Genus database with same CATH topology
 3T8I A;  2FF1 A;  1HOZ A;  3B9G A;  3MKM A;  1MAS A;  4I70 A;  4KL0 A;  1HP0 A;  3MKN A;  2YHG A;  1KIC A;  1Q8F A;  2FF2 A;  3B9X A;  4I74 A;  4I72 A;  3FZ0 A;  1R4F A;  2MAS A;  3G5I A;  4I71 A;  5TSQ A;  2C40 A;  3EPW A;  1EZR A;  1YOE A;  4I73 A;  4KPN A;  3EPX A;  4I75 A;  4KPO A;  1KIE A;  4P5F A;  3T8J A;  4WR2 A; 
#chains in the Genus database with same CATH homology
 3T8I A;  2FF1 A;  1HOZ A;  3B9G A;  3MKM A;  1MAS A;  4I70 A;  4KL0 A;  1HP0 A;  3MKN A;  2YHG A;  1KIC A;  1Q8F A;  2FF2 A;  3B9X A;  4I74 A;  4I72 A;  3FZ0 A;  1R4F A;  2MAS A;  3G5I A;  4I71 A;  5TSQ A;  2C40 A;  3EPW A;  1EZR A;  1YOE A;  4I73 A;  4KPN A;  3EPX A;  4I75 A;  4KPO A;  1KIE A;  4P5F A;  3T8J A;  4WR2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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