4I71 | Genus

Total Genus 130

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	130
sequence length	330
structure length	324
Chain Sequence	GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRAPCVHVARNPSKQMFHDLVFASTRVC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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Time for openFile(/file/5d0058537ed72cb3dc387cf6/pdb.gz): 1179 ms

reading 324 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

324 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 25 ms

Adding embedded #jmolscript: select ({0:323});backbone only;select *;

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor pubmed doi rcsb
molecule keywords	Inosine-adenosine-guanosine-nucleoside hydrolase
molecule tags	Hydrolase/hydrolase inhibitor
source organism	Trypanosoma brucei brucei
total genus	130
structure length	324
sequence length	330
ec nomenclature	ec 3.2.2.1: Purine nucleosidase.
pdb deposition date	2012-11-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01156	IU_nuc_hydro	Inosine-uridine preferring nucleoside hydrolase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase; Chain A	Ribonucleoside hydrolase-like	4i71A00

4KPNA 5TSQA 1KIEA 3EPWA 3MKMA 3T8IA 3T8JA 4WR2A 1YOEA 4KL0A 2FF2A 1KICA 4I75A 2YHGA 3MKNA 4KPOA 1MASA 3B9GA 1Q8FA 2C40A 3EPXA 4I72A 1HP0A 4I73A 1R4FA 3G5IA 1HOZA 3FZ0A 4I71A 3B9XA 1EZRA 2FF1A 4I74A 4P5FA 2MASA 4I70A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4KPN A;  5TSQ A;  1KIE A;  3EPW A;  3MKM A;  3T8I A;  3T8J A;  4WR2 A;  1YOE A;  4KL0 A;  2FF2 A;  1KIC A;  4I75 A;  2YHG A;  3MKN A;  4KPO A;  1MAS A;  3B9G A;  1Q8F A;  2C40 A;  3EPX A;  4I72 A;  1HP0 A;  4I73 A;  1R4F A;  3G5I A;  1HOZ A;  3FZ0 A;  4I71 A;  3B9X A;  1EZR A;  2FF1 A;  4I74 A;  4P5F A;  2MAS A;  4I70 A; 
#chains in the Genus database with same CATH topology
 4KPN A;  5TSQ A;  1KIE A;  3EPW A;  3MKM A;  3T8I A;  3T8J A;  4WR2 A;  1YOE A;  4KL0 A;  2FF2 A;  1KIC A;  4I75 A;  2YHG A;  3MKN A;  4KPO A;  1MAS A;  3B9G A;  1Q8F A;  2C40 A;  3EPX A;  4I72 A;  1HP0 A;  4I73 A;  1R4F A;  3G5I A;  1HOZ A;  3FZ0 A;  4I71 A;  3B9X A;  1EZR A;  2FF1 A;  4I74 A;  4P5F A;  2MAS A;  4I70 A; 
#chains in the Genus database with same CATH homology
 4KPN A;  5TSQ A;  1KIE A;  3EPW A;  3MKM A;  3T8I A;  3T8J A;  4WR2 A;  1YOE A;  4KL0 A;  2FF2 A;  1KIC A;  4I75 A;  2YHG A;  3MKN A;  4KPO A;  1MAS A;  3B9G A;  1Q8F A;  2C40 A;  3EPX A;  4I72 A;  1HP0 A;  4I73 A;  1R4F A;  3G5I A;  1HOZ A;  3FZ0 A;  4I71 A;  3B9X A;  1EZR A;  2FF1 A;  4I74 A;  4P5F A;  2MAS A;  4I70 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4I71A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations