4I71A

Crystal structure of the trypanosoma brucei inosine-adenosine-guanosine nucleoside hydrolase in complex with a trypanocidal compound
Total Genus 130

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
330
structure length
324
Chain Sequence
GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRAPCVHVARNPSKQMFHDLVFASTRVC
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (3-9)TI6 (270-273)EMPTYS2 (29-36)AH1 (13-24)AH3 (81-92)AH12 (247-252)AH6 (140-156)TIV1 (25-28)AH14 (313-324)S3 (68-70)TIV2 (38-41)AH2 (43-55)3H2 (94-96)3H1 (56-59)AH4 (99-114)TI2 (59-62)TVIII1 (75-78)AH5 (117-127)S4 (132-136)TVIII2 (128-131)TIV3 (167-170)AH7 (185-189)AH8 (191-199)S5 (158-164)O1 (199-304)S8 (296-309)TII1 (290-293)TI4 (200-203)S6 (205-208)AH9 (210-214)AH13 (260-269)AH10 (220-223)AH11 (233-244)S7 (275-281)TI8 (288-291)TI3 (176-179)TIV4 (214-217)3H3 (224-229)TI5 (229-232)TI'1 (252-255)Updating...
connected with : NaN
publication title Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
pubmed doi rcsb
molecule keywords Inosine-adenosine-guanosine-nucleoside hydrolase
molecule tags Hydrolase/hydrolase inhibitor
source organism Trypanosoma brucei brucei
total genus 130
structure length 324
sequence length 330
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2012-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 4i71A00
1MASA 2C40A 1Q8FA 3G5IA 5TSQA 4KL0A 1R4FA 1HOZA 4KPNA 4I73A 4I74A 1HP0A 3EPWA 1KIEA 1YOEA 1EZRA 2FF2A 3T8IA 2FF1A 2MASA 4I71A 4P5FA 4KPOA 1KICA 3B9XA 4I75A 3MKNA 3T8JA 4I70A 3FZ0A 4WR2A 3EPXA 3B9GA 4I72A 3MKMA 2YHGA
chains in the Genus database with same CATH superfamily
1MASA 2C40A 1Q8FA 3G5IA 5TSQA 4KL0A 1R4FA 1HOZA 4KPNA 4I73A 4I74A 1HP0A 3EPWA 1KIEA 1YOEA 1EZRA 2FF2A 3T8IA 2FF1A 2MASA 4I71A 4P5FA 4KPOA 1KICA 3B9XA 4I75A 3MKNA 3T8JA 4I70A 3FZ0A 4WR2A 3EPXA 3B9GA 4I72A 3MKMA 2YHGA
chains in the Genus database with same CATH topology
1MASA 2C40A 1Q8FA 3G5IA 5TSQA 4KL0A 1R4FA 1HOZA 4KPNA 4I73A 4I74A 1HP0A 3EPWA 1KIEA 1YOEA 1EZRA 2FF2A 3T8IA 2FF1A 2MASA 4I71A 4P5FA 4KPOA 1KICA 3B9XA 4I75A 3MKNA 3T8JA 4I70A 3FZ0A 4WR2A 3EPXA 3B9GA 4I72A 3MKMA 2YHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MAS A;  2C40 A;  1Q8F A;  3G5I A;  5TSQ A;  4KL0 A;  1R4F A;  1HOZ A;  4KPN A;  4I73 A;  4I74 A;  1HP0 A;  3EPW A;  1KIE A;  1YOE A;  1EZR A;  2FF2 A;  3T8I A;  2FF1 A;  2MAS A;  4I71 A;  4P5F A;  4KPO A;  1KIC A;  3B9X A;  4I75 A;  3MKN A;  3T8J A;  4I70 A;  3FZ0 A;  4WR2 A;  3EPX A;  3B9G A;  4I72 A;  3MKM A;  2YHG A; 
#chains in the Genus database with same CATH topology
 1MAS A;  2C40 A;  1Q8F A;  3G5I A;  5TSQ A;  4KL0 A;  1R4F A;  1HOZ A;  4KPN A;  4I73 A;  4I74 A;  1HP0 A;  3EPW A;  1KIE A;  1YOE A;  1EZR A;  2FF2 A;  3T8I A;  2FF1 A;  2MAS A;  4I71 A;  4P5F A;  4KPO A;  1KIC A;  3B9X A;  4I75 A;  3MKN A;  3T8J A;  4I70 A;  3FZ0 A;  4WR2 A;  3EPX A;  3B9G A;  4I72 A;  3MKM A;  2YHG A; 
#chains in the Genus database with same CATH homology
 1MAS A;  2C40 A;  1Q8F A;  3G5I A;  5TSQ A;  4KL0 A;  1R4F A;  1HOZ A;  4KPN A;  4I73 A;  4I74 A;  1HP0 A;  3EPW A;  1KIE A;  1YOE A;  1EZR A;  2FF2 A;  3T8I A;  2FF1 A;  2MAS A;  4I71 A;  4P5F A;  4KPO A;  1KIC A;  3B9X A;  4I75 A;  3MKN A;  3T8J A;  4I70 A;  3FZ0 A;  4WR2 A;  3EPX A;  3B9G A;  4I72 A;  3MKM A;  2YHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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