4I74A

Crystal structure of the trypanosoma brucei inosine-adenosine-guanosine nucleoside hydrolase in complex with compound uamc-00312 and allosterically inhibited by a ni2+ ion
Total Genus 129

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
330
structure length
327
Chain Sequence
GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGPCVHVARNPSKQMFHDLVFASTRVC
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (3-9)TI7 (270-273)AH1 (13-24)EMPTYAH12 (260-269)AH6 (140-156)TI1 (25-28)AH13 (313-324)S3 (68-70)TIV1 (38-41)AH2 (43-61)AH3 (81-92)3H1 (94-96)TVIII1 (75-78)O1 (199-304)AH4 (99-114)AH5 (117-127)TIV2 (128-131)S4 (132-136)S5 (158-164)TIV3 (167-170)AH7 (185-189)AH8 (191-199)S6 (205-208)S10 (305-309)TI4 (200-203)AH9 (210-214)S7 (218-219)AH10 (220-224)TI5 (229-232)AH11 (233-244)3H3 (247-249)TI6 (251-254)S8 (256-257)S9 (275-279)TI9 (288-291)S2 (29-36)TI3 (176-179)TII1 (290-293)TIV4 (214-217)3H2 (225-229)Updating...
connected with : NaN
publication title Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
pubmed doi rcsb
molecule keywords Inosine-adenosine-guanosine-nucleoside hydrolase
molecule tags Hydrolase/hydrolase inhibitor
source organism Trypanosoma brucei brucei
total genus 129
structure length 327
sequence length 330
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2012-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 4i74A00
3B9XA 1KIEA 4KL0A 1R4FA 4I71A 4KPNA 3EPXA 3FZ0A 4I74A 1HP0A 4I70A 2FF2A 4I72A 2C40A 5TSQA 3B9GA 4I73A 1MASA 1Q8FA 1YOEA 3MKNA 4I75A 4P5FA 2MASA 3MKMA 3G5IA 3T8JA 1HOZA 2YHGA 1EZRA 4WR2A 3EPWA 4KPOA 3T8IA 1KICA 2FF1A
chains in the Genus database with same CATH superfamily
3B9XA 1KIEA 4KL0A 1R4FA 4I71A 4KPNA 3EPXA 3FZ0A 4I74A 1HP0A 4I70A 2FF2A 4I72A 2C40A 5TSQA 3B9GA 4I73A 1MASA 1Q8FA 1YOEA 3MKNA 4I75A 4P5FA 2MASA 3MKMA 3G5IA 3T8JA 1HOZA 2YHGA 1EZRA 4WR2A 3EPWA 4KPOA 3T8IA 1KICA 2FF1A
chains in the Genus database with same CATH topology
3B9XA 1KIEA 4KL0A 1R4FA 4I71A 4KPNA 3EPXA 3FZ0A 4I74A 1HP0A 4I70A 2FF2A 4I72A 2C40A 5TSQA 3B9GA 4I73A 1MASA 1Q8FA 1YOEA 3MKNA 4I75A 4P5FA 2MASA 3MKMA 3G5IA 3T8JA 1HOZA 2YHGA 1EZRA 4WR2A 3EPWA 4KPOA 3T8IA 1KICA 2FF1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B9X A;  1KIE A;  4KL0 A;  1R4F A;  4I71 A;  4KPN A;  3EPX A;  3FZ0 A;  4I74 A;  1HP0 A;  4I70 A;  2FF2 A;  4I72 A;  2C40 A;  5TSQ A;  3B9G A;  4I73 A;  1MAS A;  1Q8F A;  1YOE A;  3MKN A;  4I75 A;  4P5F A;  2MAS A;  3MKM A;  3G5I A;  3T8J A;  1HOZ A;  2YHG A;  1EZR A;  4WR2 A;  3EPW A;  4KPO A;  3T8I A;  1KIC A;  2FF1 A; 
#chains in the Genus database with same CATH topology
 3B9X A;  1KIE A;  4KL0 A;  1R4F A;  4I71 A;  4KPN A;  3EPX A;  3FZ0 A;  4I74 A;  1HP0 A;  4I70 A;  2FF2 A;  4I72 A;  2C40 A;  5TSQ A;  3B9G A;  4I73 A;  1MAS A;  1Q8F A;  1YOE A;  3MKN A;  4I75 A;  4P5F A;  2MAS A;  3MKM A;  3G5I A;  3T8J A;  1HOZ A;  2YHG A;  1EZR A;  4WR2 A;  3EPW A;  4KPO A;  3T8I A;  1KIC A;  2FF1 A; 
#chains in the Genus database with same CATH homology
 3B9X A;  1KIE A;  4KL0 A;  1R4F A;  4I71 A;  4KPN A;  3EPX A;  3FZ0 A;  4I74 A;  1HP0 A;  4I70 A;  2FF2 A;  4I72 A;  2C40 A;  5TSQ A;  3B9G A;  4I73 A;  1MAS A;  1Q8F A;  1YOE A;  3MKN A;  4I75 A;  4P5F A;  2MAS A;  3MKM A;  3G5I A;  3T8J A;  1HOZ A;  2YHG A;  1EZR A;  4WR2 A;  3EPW A;  4KPO A;  3T8I A;  1KIC A;  2FF1 A; 
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#similar chains, but unknotted
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