4I74 | Genus

Total Genus 129

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	129
sequence length	330
structure length	327
Chain Sequence	GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGPCVHVARNPSKQMFHDLVFASTRVC

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor pubmed doi rcsb
molecule keywords	Inosine-adenosine-guanosine-nucleoside hydrolase
molecule tags	Hydrolase/hydrolase inhibitor
source organism	Trypanosoma brucei brucei
total genus	129
structure length	327
sequence length	330
ec nomenclature	ec 3.2.2.1: Purine nucleosidase.
pdb deposition date	2012-11-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01156	IU_nuc_hydro	Inosine-uridine preferring nucleoside hydrolase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase; Chain A	Ribonucleoside hydrolase-like	4i74A00

1MASA 4KPNA 2MASA 3T8IA 4P5FA 1HP0A 4KL0A 4I70A 3EPXA 3MKMA 2YHGA 1HOZA 4I75A 1Q8FA 1YOEA 3EPWA 2FF1A 3G5IA 1EZRA 4I71A 5TSQA 2FF2A 4I72A 4I73A 4WR2A 3B9GA 3T8JA 1R4FA 3MKNA 3B9XA 4KPOA 4I74A 1KIEA 1KICA 3FZ0A 2C40A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1MAS A;  4KPN A;  2MAS A;  3T8I A;  4P5F A;  1HP0 A;  4KL0 A;  4I70 A;  3EPX A;  3MKM A;  2YHG A;  1HOZ A;  4I75 A;  1Q8F A;  1YOE A;  3EPW A;  2FF1 A;  3G5I A;  1EZR A;  4I71 A;  5TSQ A;  2FF2 A;  4I72 A;  4I73 A;  4WR2 A;  3B9G A;  3T8J A;  1R4F A;  3MKN A;  3B9X A;  4KPO A;  4I74 A;  1KIE A;  1KIC A;  3FZ0 A;  2C40 A; 
#chains in the Genus database with same CATH topology
 1MAS A;  4KPN A;  2MAS A;  3T8I A;  4P5F A;  1HP0 A;  4KL0 A;  4I70 A;  3EPX A;  3MKM A;  2YHG A;  1HOZ A;  4I75 A;  1Q8F A;  1YOE A;  3EPW A;  2FF1 A;  3G5I A;  1EZR A;  4I71 A;  5TSQ A;  2FF2 A;  4I72 A;  4I73 A;  4WR2 A;  3B9G A;  3T8J A;  1R4F A;  3MKN A;  3B9X A;  4KPO A;  4I74 A;  1KIE A;  1KIC A;  3FZ0 A;  2C40 A; 
#chains in the Genus database with same CATH homology
 1MAS A;  4KPN A;  2MAS A;  3T8I A;  4P5F A;  1HP0 A;  4KL0 A;  4I70 A;  3EPX A;  3MKM A;  2YHG A;  1HOZ A;  4I75 A;  1Q8F A;  1YOE A;  3EPW A;  2FF1 A;  3G5I A;  1EZR A;  4I71 A;  5TSQ A;  2FF2 A;  4I72 A;  4I73 A;  4WR2 A;  3B9G A;  3T8J A;  1R4F A;  3MKN A;  3B9X A;  4KPO A;  4I74 A;  1KIE A;  1KIC A;  3FZ0 A;  2C40 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4I74A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations