4I75 | Genus

Total Genus 126

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	126
sequence length	330
structure length	325
Chain Sequence	GSHMAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMSTHEEILRDGDAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRAPCVHVARNPSKQMFHDLVFASTRVC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 325 atoms

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325 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor pubmed doi rcsb
molecule keywords	Inosine-adenosine-guanosine-nucleoside hydrolase
molecule tags	Hydrolase
source organism	Trypanosoma brucei brucei
total genus	126
structure length	325
sequence length	330
chains with identical sequence	B
ec nomenclature	ec 3.2.2.1: Purine nucleosidase.
pdb deposition date	2012-11-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01156	IU_nuc_hydro	Inosine-uridine preferring nucleoside hydrolase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.245.10	Alpha Beta	Alpha-Beta Complex	Inosine-uridine Nucleoside N-ribohydrolase; Chain A	Ribonucleoside hydrolase-like	4i75A00

2C40A 1HOZA 4KPOA 4P5FA 1KICA 3MKMA 3EPXA 2FF2A 3FZ0A 5TSQA 1R4FA 3T8IA 4I72A 4WR2A 2FF1A 3G5IA 3EPWA 1HP0A 3MKNA 4KL0A 1Q8FA 1EZRA 2MASA 4I70A 3B9GA 3T8JA 2YHGA 1KIEA 1MASA 4I71A 3B9XA 4I73A 4KPNA 4I75A 4I74A 1YOEA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 2C40 A;  1HOZ A;  4KPO A;  4P5F A;  1KIC A;  3MKM A;  3EPX A;  2FF2 A;  3FZ0 A;  5TSQ A;  1R4F A;  3T8I A;  4I72 A;  4WR2 A;  2FF1 A;  3G5I A;  3EPW A;  1HP0 A;  3MKN A;  4KL0 A;  1Q8F A;  1EZR A;  2MAS A;  4I70 A;  3B9G A;  3T8J A;  2YHG A;  1KIE A;  1MAS A;  4I71 A;  3B9X A;  4I73 A;  4KPN A;  4I75 A;  4I74 A;  1YOE A; 
#chains in the Genus database with same CATH topology
 2C40 A;  1HOZ A;  4KPO A;  4P5F A;  1KIC A;  3MKM A;  3EPX A;  2FF2 A;  3FZ0 A;  5TSQ A;  1R4F A;  3T8I A;  4I72 A;  4WR2 A;  2FF1 A;  3G5I A;  3EPW A;  1HP0 A;  3MKN A;  4KL0 A;  1Q8F A;  1EZR A;  2MAS A;  4I70 A;  3B9G A;  3T8J A;  2YHG A;  1KIE A;  1MAS A;  4I71 A;  3B9X A;  4I73 A;  4KPN A;  4I75 A;  4I74 A;  1YOE A; 
#chains in the Genus database with same CATH homology
 2C40 A;  1HOZ A;  4KPO A;  4P5F A;  1KIC A;  3MKM A;  3EPX A;  2FF2 A;  3FZ0 A;  5TSQ A;  1R4F A;  3T8I A;  4I72 A;  4WR2 A;  2FF1 A;  3G5I A;  3EPW A;  1HP0 A;  3MKN A;  4KL0 A;  1Q8F A;  1EZR A;  2MAS A;  4I70 A;  3B9G A;  3T8J A;  2YHG A;  1KIE A;  1MAS A;  4I71 A;  3B9X A;  4I73 A;  4KPN A;  4I75 A;  4I74 A;  1YOE A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4I75A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations